Results 21 to 30 of about 158,981 (293)
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b
Journal of Sport and Health Science, 2022 Background: Exercise is beneficial for muscle atrophy. Peroxisome proliferator-activated receptor gamma (PPARγ) and microRNA-29b (miR-29b) have been reported to be responsible for angiotensinⅡ (AngⅡ)-induced muscle atrophy. However, it is unclear whether
Qi Liu +8 more
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The Ontogeny of Cardiac Regeneration [PDF]
Circulation Research, 2011 ### Transient Regenerative Potential of the Neonatal Mouse Heart Porello et al Science . 2011;331:1078–1080 The regenerative capacity of adult human hearts after infarction seems vestigial at best, perhaps because of the poor proliferative capacity of terminally differentiated cardiomyocytes and desecration of the local environment that would ...
Robert M, Graham, Richard P, Harvey
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Cell Death and Disease, 2022 The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation.
Jitai Zhang +11 more
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Cells, 2023 Background: Antithymocyte globulins (ATG) are T cell-depleting antibodies used in solid organ transplantation for induction therapy in sensitized patients with a high risk of graft rejection.
Dragan Copic +6 more
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Hyaluronan and cardiac regeneration [PDF]
Journal of Biomedical Science, 2014 Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations.
BONAFÈ, FRANCESCA +5 more
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Mechanisms of Cardiac Regeneration [PDF]
Developmental Cell, 2016 Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death worldwide. Although all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can regenerate myocardium throughout life. In addition, new studies indicate that mammals
Uygur, Aysu, Lee, Richard T.
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Cardiac regeneration validated [PDF]
Nature Biotechnology, 2015 Naumova et al. reply: We appreciate the comments from Malliaras and Marban1 describing their work on developing imaging markers of therapeutic efficacy2 that was not mentioned in our review3. Owing to the page limitation, we were not able to cite all the literature published on this topic.
Konstantinos, Malliaras +1 more
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Cardiac regeneration and diabetes [PDF]
Regenerative Medicine Research, 2014 The prevalence of diabetes continues to increase world-wide and is a leading cause of morbidity, mortality, and rapidly rising health care costs. Although strict glucose control combined with good pharmacological and non-pharmacologic interventions can increase diabetic patient life span, the frequency and mortality of myocardial ischemia and ...
Cai Lu, Keller Bradley B
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Cardiac Neural Crest and Cardiac Regeneration
Cells, 2022 Neural crest cells (NCCs) are a vertebrate-specific, multipotent stem cell population that have the ability to migrate and differentiate into various cell populations throughout the embryo during embryogenesis. The heart is a muscular and complex organ whose primary function is to pump blood and nutrients throughout the body.
Shannon Erhardt, Jun Wang
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miRNA in cardiac development and regeneration [PDF]
Cell Regeneration, 2021 AbstractIschemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as myocardial infarction. MicroRNAs (miRNAs), a class of non-
Zhaohui Ouyang, Ke Wei
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