Porcine Models of Heart Regeneration [PDF]
, 2022 Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal ...
Katherine E. Yutzey +1 more
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Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs. Regenerative Systems [PDF]
, 2022 Innate and adaptive leukocytes rapidly mobilize to ischemic tissues after myocardial infarction in response to damage signals released from necrotic cells. Leukocytes play important roles in cardiac repair and regeneration such as inflammation initiation
Elizabeth Anne Peterson +2 more
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Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart—Part I: Experimental Injury Models to Study Cardiac Regeneration [PDF]
, 2023 Cardiovascular diseases are the leading cause of death worldwide, among which, ischemic heart disease is the most prevalent. Myocardial infarction results from occlusion of a coronary artery, which leads to an insufficient blood supply to the myocardium.
Sheila Caño-Carrillo +9 more
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Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart—Part II: Molecular Mechanisms of Cardiac Regeneration [PDF]
, 2023 Cardiovascular diseases are the leading cause of death worldwide, among which ischemic heart disease is the most representative. Myocardial infarction results from occlusion of a coronary artery, which leads to an insufficient blood supply to the ...
Sheila Caño-Carrillo +9 more
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The Ontogeny of Cardiac Regeneration [PDF]
Circulation Research, 2011 ### Transient Regenerative Potential of the Neonatal Mouse Heart Porello et al Science . 2011;331:1078–1080 The regenerative capacity of adult human hearts after infarction seems vestigial at best, perhaps because of the poor proliferative capacity of terminally differentiated cardiomyocytes and desecration of the local environment that would ...
Robert M, Graham, Richard P, Harvey
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Hyaluronan and cardiac regeneration [PDF]
Journal of Biomedical Science, 2014 Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations.
BONAFÈ, FRANCESCA +5 more
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Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics [PDF]
, 2021 The neonatal mammalian heart exhibits a remarkable regenerative potential, which includes fibrotic scar resolution and the generation of new cardiomyocytes.
Adwiteeya Misra +5 more
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The Key Lnc (RNA)s in Cardiac and Skeletal Muscle Development, Regeneration, and Disease [PDF]
, 2021 Non-coding RNAs (ncRNAs) play a key role in the regulation of transcriptional and epigenetic activity in mammalian cells. Comprehensive analysis of these ncRNAs has revealed sophisticated gene regulatory mechanisms which finely tune the proper gene ...
Naya, Francisco J. +3 more
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Route 411 to Cardiac Regeneration
JACC: Basic to Translational Science, 2022 [Figure: see text]
Siel Van den Bogaert +1 more
openaire +4 more sources
Developmental Aspects of Cardiac Adaptation to Increased Workload [PDF]
, 2023 The heart is capable of extensive adaptive growth in response to the demands of the body. When the heart is confronted with an increased workload over a prolonged period, it tends to cope with the situation by increasing its muscle mass.
Marketa Hlavackova +6 more
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