Results 11 to 20 of about 87,451 (296)
A neonatal blueprint for cardiac regeneration [PDF]
Stem Cell Research, 2014 Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure.
Enzo R. Porrello, Eric N. Olson
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The multifaceted nature of endogenous cardiac regeneration [PDF]
Frontiers in Cardiovascular Medicine, 2023 Since the first evidence of cardiac regeneration was observed, almost 50 years ago, more studies have highlighted the endogenous regenerative abilities of several models following cardiac injury.
Laura Rolland, Chris Jopling
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Cardiac Neural Crest and Cardiac Regeneration [PDF]
Cells, 2022 Neural crest cells (NCCs) are a vertebrate-specific, multipotent stem cell population that have the ability to migrate and differentiate into various cell populations throughout the embryo during embryogenesis. The heart is a muscular and complex organ whose primary function is to pump blood and nutrients throughout the body.
Shannon Erhardt, Jun Wang
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Mechanisms of Cardiac Regeneration [PDF]
Developmental Cell, 2016 Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death worldwide. Although all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can regenerate myocardium throughout life. In addition, new studies indicate that mammals
Uygur, Aysu, Lee, Richard T.
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Circulation Research, 2017 Palliative surgery for congenital heart disease has allowed patients with previously lethal heart malformations to survive and, in most cases, to thrive. However, these procedures often place pressure and volume loads on the heart, and over time, these chronic loads can cause heart failure.
Francisco X, Galdos +5 more
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microRNA and Cardiac Regeneration [PDF]
, 2015 Heart diseases are a very common health problem in developed as well as developing countries. In particular, ischemic heart disease and heart failure represent a plague for the patients and for the society. Loss of cardiac tissue after myocardial infarction or dysfunctioning tissue in nonischemic cardiomyopathies may result in cardiac failure.
GNECCHI, MASSIMILIANO +2 more
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Non-coding RNAs in Cardiac Regeneration [PDF]
Frontiers in Physiology, 2021 The adult heart has a limited capacity to replace or regenerate damaged cardiac tissue following severe myocardial injury. Thus, therapies facilitating the induction of cardiac regeneration holds great promise for the treatment of end-stage heart failure,
Ting Yuan, Jaya Krishnan
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, 2021 This detailed book addresses major goals of regenerative medicine and the cardiovascular research community with techniques to replenish lost cardiomyocytes, avoid scar-associated pathology, and improve myocardial infarction (MI) outcomes. The collection
Kühn, Bernhard.editor.edthttp://id.loc.gov/vocabulary/relators/edt +2 more
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Journal of the American College of Cardiology, 2006 The role and even the existence of new myocyte formation in the adult heart remain controversial. Documentation of cell cycle regulators, deoxyribonucleic acid synthesis, and mitotic images has only in part modified the view that myocardial growth can be accomplished exclusively from hypertrophy of an irreplaceable population of differentiated myocytes.
Anversa, Piero +2 more
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Science, 2012 The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact.
Wen-Yee, Choi, Kenneth D, Poss
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