Results 81 to 90 of about 1,204,541 (198)

Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

, 2023
Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure.
Abdul Majid, Md Monirul Hoque, Joy Olaoluwa Gbadegoye, Djamel Lebeche, Fasilat Oluwakemi Hassan   +4 more
core   +1 more source

Pathological Structural Alterations of Serous Cell Cilia in the Parietal Pericardium of Patients With Heart Failure Induced by Dilated Cardiomyopathy

Reviews in Cardiovascular Medicine
Background: This study aimed to examine pathological surface structural changes in serous cells of the pericardial parietal layer in patients with heart failure due to dilated cardiomyopathy.
Yingtian Liu, Yaping Xu, Yan Chen, Yuexin Yu, Ziyu Liu, Xiangli Zhang, Bin Yang, Zhikun Guo   +7 more
doaj   +1 more source

Safety and efficacy of direct cardiac shockwave therapy in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (the CAST-HF trial): study protocol for a randomized controlled trial—an update

Trials, 2022
Background Coronary artery disease (CAD) remains a severe socio-economic burden in the Western world. Coronary obstruction and subsequent myocardial ischemia result in the progressive replacement of contractile myocardium with dysfunctional, fibrotic ...
Felix Nägele, Leo Pölzl, Michael Graber, Jakob Hirsch, Agnes Mayr, Mathias Pamminger, Felix Troger, Markus Theurl, Michael Schreinlechner, Nikolay Sappler, Christian Dorfmüller, Martina Mitrovic, Hanno Ulmer, Michael Grimm, Can Gollmann-Tepeköylü, Johannes Holfeld   +15 more
doaj   +1 more source

Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs. Regenerative Systems

, 2022
Innate and adaptive leukocytes rapidly mobilize to ischemic tissues after myocardial infarction in response to damage signals released from necrotic cells. Leukocytes play important roles in cardiac repair and regeneration such as inflammation initiation
Elizabeth Anne Peterson, Jisheng Sun, Jinhu Wang   +2 more
core   +1 more source

Cardiac regeneration as an environmental adaptation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020
Heart failure is a devastating disease that affects more than 26 million individuals worldwide and has a 5-year survival rate of less than 50%, with its development in part reflecting the inability of the adult mammalian heart to regenerate damaged myocardium.
Akane, Sakaguchi, Chihiro, Nishiyama, Wataru, Kimura   +2 more
openaire   +2 more sources

A single-cell atlas revealing cellular heterogeneity across healthy and diseased human thymus

Nature Communications
The human thymus plays a key role in the development of the adaptive immune system. Its development and pathologic aberrations with missing involution occupy the scientific world for years.
Martin Direder, Matthias Wielscher, Melanie Salek, Maria Laggner, Dragan Copic, Katharina Klas, Daniel Bormann, Bahar Golabi, Hannes Kühtreiber, Marie-Therese Lingitz, Leonhard Müllauer, Ana-Iris Schiefer, Wolfgang Weninger, Clemens Aigner, Hendrik Jan Ankersmit, Michael Mildner, Bernhard Moser   +16 more
doaj   +1 more source

Targeting Mettl14 Using an RNA‐Targeting Clustered Regularly Interspaced Short Palindromic Repeat‐High‐Fidelity Cas13x System Attenuates Doxorubicin‐Induced Cardiotoxicity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin is an effective chemotherapy drug used to treat various types of cancer. However, doxorubicin treatment is associated with cardiotoxicity, which limits its clinical use.
Wensi Wan, Caiyue Cui, Yi Zhou, Jiaqi Wang, Xuan Zhao, Xinxin Cui, Jiangpeng Sun, Pujiao Yu, Jingyi Feng, Tianhui Wang, Lijun Wang, Jiahong Xu   +11 more
doaj   +1 more source

microRNAs in cardiac regeneration and cardiovascular disease [PDF]

, 2013
microRNAs (miRNAs) are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes.
Zhan-Peng Huang, Wu, GengZe, GengZe Wu, Huang, Zhan-Peng, Wang, Da-Zhi, Da-Zhi Wang   +5 more
core   +2 more sources

Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration

, 2023
Over the past decades, huge scientific efforts have been put into cardiac regeneration strategies. Although several strategies have been accepted for use in clinical practice, none has demonstrated great success in regenerating the cardiac tissue ...
Jorba, Ignasi, Bouten, Carlijn V.C.; id_orcid, Nikolic, Milica   +2 more
core   +1 more source

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese

Frontiers in Pharmacology
BackgroundAcute coronary syndrome (ACS) is a critical cardiovascular condition with diverse clinical presentations, necessitating personalized therapeutic approaches.
Hongmei Lai, Hongmei Lai, Jinhang Zhu, Jing Tao, Jing Tao, Zitong Guo, Zitong Guo, Xiaolin Yu, Xiaolin Yu, Xin Shen, Ting Wang, Ying Wang, Ying Wang, Huan Cai, Huan Cai, Xiao Cai, Zhenbang Wei, Yining Yang, Yining Yang   +18 more
doaj   +1 more source