Results 11 to 20 of about 119,697 (212)
Research progress of zebrafish heart regeneration models
浙江大学学报. 农业与生命科学版, 2022 Heart disease is a major threat to human health due to the high morbidity and mortality rates. As a result, the discovery of adult zebrafish heart regeneration provides a new perspective for the study and treatment of human heart diseases.
ZHANG Weijia, LIANG Jinxiu, HAN Peidong
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Metabolic Regulation of Cardiac Regeneration
Frontiers in Cardiovascular Medicine, 2022 The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining ...
Xuewen Duan +2 more
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A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function
JACC: Basic to Translational Science, 2016 Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment.
Isaac Perea-Gil, MS +10 more
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Transcriptional Programs and Regeneration Enhancers Underlying Heart Regeneration
Journal of Cardiovascular Development and Disease, 2018 The heart plays the vital role of propelling blood to the entire body, which is essential to life. While maintaining heart function is critical, adult mammalian hearts poorly regenerate damaged cardiac tissue upon injury and form scar tissue instead ...
Ian J. Begeman, Junsu Kang
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Frontiers in Cardiovascular Medicine, 2021 Despite considerable efforts carried out to develop stem/progenitor cell-based technologies aiming at replacing and restoring the cardiac tissue following severe damages, thus far no strategies based on adult stem cell transplantation have been ...
Chiara Bongiovanni +11 more
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Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
npj Systems Biology and Applications, 2017 Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated
Oriol Iborra-Egea +6 more
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Mechanisms and Therapeutic Targets of Cardiac Regeneration: Closing the Age Gap
Frontiers in Cardiovascular Medicine, 2018 While a regenerative response is limited in the mammalian adult heart, it has been recently shown that the neonatal mammalian heart possesses a marked but transient capacity for regeneration after cardiac injury, including myocardial infarction.
Raphael F. P. Castellan, Marco Meloni
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Preconditioning boosts regenerative programmes in the adult zebrafish heart [PDF]
Open Biology, 2016 During preconditioning, exposure to a non-lethal harmful stimulus triggers a body-wide increase of survival and pro-regenerative programmes that enable the organism to better withstand the deleterious effects of subsequent injuries.
Anne-Sophie de Preux Charles +4 more
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Endothelial Contributions to Zebrafish Heart Regeneration
Journal of Cardiovascular Development and Disease, 2018 Studies over the past two decades have shown heart regeneration in zebrafish to be a dynamic process, choreographed by multiple cell types. In particular, recent work has identified revascularization of the wound to be a sentinel event during heart ...
Cristina E. Fernandez +2 more
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Tg(Δ113p53:cmyc) Transgene Upregulates glut1 Expression to Promote Zebrafish Heart Regeneration
Journal of Cardiovascular Development and Disease, 2023 The heart switches its main metabolic substrate from glucose to fatty acids shortly after birth, which is one of reasons for the loss of heart regeneration capability in adult mammals.
Zimu Tang +3 more
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