Results 31 to 40 of about 801,889 (178)
Revisiting Preadolescent Cardiomyocyte Proliferation in Mice [PDF]
Circulation Research, 2016 No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice Alkass et al Cell . 2015;163:1026–1036. Understanding cardiomyocyte cell cycle regulation after birth is key to optimizing regenerative strategies for the heart post injury, yet poses multiple technical challenges, as evidenced by recent studies that have arrived at divergent ...
Hirai M. +3 more
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Deep Image Segmentation for Cardiomyocyte Proliferation. [PDF]
JACC Basic Transl Sci[Figure: see text] [Figure: see text]
Samee MAH, Martin JF.
europepmc +3 more sources
Live cell screening identifies glycosides as enhancers of cardiomyocyte cell cycle activity
Frontiers in Cardiovascular Medicine, 2022 Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, it is poorly understood how cardiomyocyte proliferation is regulated, and no factor identified to promote mammalian cardiomyocyte proliferation has been ...
Ajit Magadum +11 more
doaj +1 more source
, 2022 Cardiomyocyte proliferation is an important source of new myocardium during heart development and regeneration. Consequently, mutations in drivers of cardiomyocyte proliferation cause congenital heart disease, and infarcted human hearts scar because ...
Felicia Wranitz (12026678) +6 more
core +1 more source
Proliferation of cardiomyocytes a question unresolved
Frontiers in Bioscience, 2009 In the past, human heart has been considered a post-mitotic organ formed by cells, like adult cardiomyocytes, terminally differentiated and incapable of proliferation. This paradigm has been shaken by recent works indicating that postnatal adult cardiomyocytes are able to re-enter in the cell cycle and proliferate.
DE FALCO M, COBELLIS G, DE LUCA, Antonio
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TWEAK is a positive regulator of cardiomyocyte proliferation [PDF]
Cardiovascular Research, 2009 Proliferation of mammalian cardiomyocytes stops during the first weeks after birth, preventing the heart from regenerating after injury. Recently, several studies have indicated that induction of cardiomyocyte proliferation can be utilized to regenerate the mammalian heart.
Novoyatleva T +6 more
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Ruvbl2 Is a Negative Regulator of Zebrafish Cardiomyocyte Proliferation
, 2020 In contrast to mammals, which are unable to regenerate their hearts, the zebrafish is capable of heart regeneration through robust proliferation of pre-existing cardiomyocytes.
Sharpe, Michka
core +3 more sources
Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. [PDF]
PLoS ONE, 2016 The molecular mechanisms that regulate cardiomyocyte proliferation during embryonic heart growth are not completely deciphered yet. In a forward genetic N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we identified the recessive embryonic-lethal ...
Steffen Just +5 more
doaj +1 more source
A Hippo “AKT” Regulates Cardiomyocyte Proliferation [PDF]
Circulation Research, 2015 Heart failure is a costly and deadly disease affecting >23 million patients worldwide.1 At the core of the pathophysiology of heart failure is the inability of the adult mammalian heart to regenerate after myocardial loss, which is in marked contrast to terelost fish,2–4 urodele amphibians,5–8 and mammalian neonates.9,10 In mammals, most of the ...
Feng, Xiao +2 more
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Corrigendum to ‘Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration’ [PDF]
, 2022 Corrigendum to ‘Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart ...
Wang, Tingting +14 more
core +1 more source