Results 21 to 30 of about 801,889 (178)

Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish.

PLoS Genetics, 2021
In contrast to mammals, the zebrafish maintains its cardiomyocyte proliferation capacity throughout adulthood. However, neither the molecular mechanisms that orchestrate the proliferation of cardiomyocytes during developmental heart growth nor in the ...
Anja Bühler, Bernd M Gahr, Deung-Dae Park, Alberto Bertozzi, Alena Boos, Mohankrishna Dalvoy, Alexander Pott, Franz Oswald, Rhett A Kovall, Bernhard Kühn, Gilbert Weidinger, Wolfgang Rottbauer, Steffen Just   +12 more
doaj   +2 more sources

From Cardiomyocyte Proliferation to Regenerative Ecosystems. [PDF]

JACC Basic Transl Sci
Nahrendorf M.
europepmc   +3 more sources

Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration

Frontiers in Cell and Developmental Biology, 2022
Cardiomyocyte proliferation is an important source of new myocardium during heart development and regeneration. Consequently, mutations in drivers of cardiomyocyte proliferation cause congenital heart disease, and infarcted human hearts scar because ...
Michka Sharpe, Michka Sharpe, Michka Sharpe, Juan Manuel González-Rosa, Juan Manuel González-Rosa, Juan Manuel González-Rosa, Felicia Wranitz, Felicia Wranitz, Spencer Jeffrey, Katherine Copenhaver, Katherine Copenhaver, C. Geoffrey Burns, C. Geoffrey Burns, C. Geoffrey Burns, Caroline E. Burns, Caroline E. Burns, Caroline E. Burns, Caroline E. Burns   +17 more
doaj   +1 more source

Noncoding RNA and Cardiomyocyte Proliferation [PDF]

Stem Cells International, 2017
It is acknowledged that postnatal mammalian cardiomyocytes (CMs) turn over with a very limited efficacy in both physiological and pathological conditions. Recent studies showed that those newly formed CMs are derived from preexisting CMs. Thus, stimulating CM proliferation becomes a promising strategy for inducing cardiac regeneration.
Shuang Qu, Chunyu Zeng, Wei Eric Wang
openaire   +3 more sources

Advances in Drug Discovery for Cardiomyocyte Proliferation. [PDF]

Curr Treat Options Cardiovasc Med
Abstract Purpose of Review This review explores current advancements in drug discovery for promoting cardiomyocyte proliferation and highlights key challenges in translating these findings to clinical applications. Recent Findings
Wintruba KL, Wolf MJ, van Berlo JH, Saucerman JJ.   +3 more
europepmc   +3 more sources

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis

Biomolecules & Biomedicine, 2022
The regenerative potential of cardiomyocytes in adult mammals is limited. Previous studies reported that cardiomyocyte proliferation is suppressed by AMP-activated protein kinase (AMPK).
Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A. Jose, Zhuxin Li, Wei Eric Wang, Qing Rex Lyu, Chunyu Zeng   +12 more
doaj   +1 more source

Epigenetic Control of Mammalian Cardiomyocyte Proliferation. [PDF]

Curr Cardiol Rep
Postnatal shutdown of the mammalian cardiomyocyte cell cycle underpins limited regenerative capacity of the adult heart. An epigenetic programme regulates a switch at birth from a proliferative state to functional maturity. Identification of the molecular components regulating this switch has revealed therapeutic opportunities for heart regeneration ...
Butera F, Elliott DA, Porrello ER.
europepmc   +4 more sources

Metabolic Determinants of Cardiomyocyte Proliferation

Stem Cells, 2022
Abstract The adult mammalian heart is recalcitrant to regeneration after injury, in part due to the postmitotic nature of cardiomyocytes. Accumulating evidence suggests that cardiomyocyte proliferation in fetal or neonatal mammals and in regenerative non-mammalian models depends on a conducive metabolic state.
Tamer M A Mohamed, Riham Abouleisa, Bradford G Hill   +2 more
openaire   +2 more sources

Isolation of Embryonic Cardiomyocytes and Cell Proliferation Assay Using Genetically Engineered Reporter Mouse Model

Bio-Protocol, 2023
Congenital heart disease (CHD) is often associated with myogenic defects. During heart development, cardiomyocyte growth requires essential cues from extrinsic factors such as insulin-like growth factor 2 (IGF-2).
Maren Beall, Deqiang Li, Jihyun Jang
doaj   +1 more source

E2F4 is required for cardiomyocyte proliferation [PDF]

Cardiovascular Research, 2009
Although the fundamental role of the E2F transcription factor family in cell proliferation is well established, the specific function of E2F4 is unclear. On the basis of findings from cell culture experiments, E2F4 is generally considered as an inhibitor of cell proliferation.
Machteld J, van Amerongen, Florian, Diehl, Tatyana, Novoyatleva, Chinmoy, Patra, Felix B, Engel   +4 more
openaire   +2 more sources