Results 11 to 20 of about 801,889 (178)
In Vivo Methods to Monitor Cardiomyocyte Proliferation [PDF]
Journal of Cardiovascular Development and Disease, 2022 Adult mammalian cardiomyocytes demonstrate scarce cycling and even lower proliferation rates in response to injury. Signals that enhance cardiomyocyte proliferation after injury will be groundbreaking, address unmet clinical needs, and represent new ...
Alexander Young +2 more
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Tead1 is required for perinatal cardiomyocyte proliferation.
PLoS ONE, 2019 Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte number is determined primarily in the embryonic and perinatal period, as adult cardiomyocyte proliferation is restricted in comparison to that seen ...
Ruya Liu +8 more
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Factors affecting the proliferation of cardiomyocyte [PDF]
E3S Web of Conferences, 2020 Heart is one of the most significant organs in mammalian animals, it functions as a pump to make the blood flow from heart to the body tissue and turn back to heart, which can provide the oxygen and other nutrients with the body tissue and carry the ...
Cao Xixian
doaj +3 more sources
Stereological estimation of cardiomyocyte number and proliferation
Methods, 2021 Cardiovascular diseases remain the leading cause of death, largely due to the limited regenerative capacity of the adult mammalian heart. Yet, neonatal mammals were shown to regenerate the myocardium after injury by increasing the proliferation of pre-existing cardiomyocytes. Re-activation of cardiomyocyte proliferation in adulthood has been considered
Sampaio-Pinto, Vasco +5 more
openaire +3 more sources
Cardiomyocyte proliferation, a target for cardiac regeneration
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 Cardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of cardiac function and ultimately to congestive heart failure. Despite significant advances, conventional treatments do not correct the defects in cardiac muscle cell numbers and the prognosis of congestive heart failure remains poor.
Payan, Sandy +2 more
openaire +3 more sources
HeliyonEnhancing cardiomyocyte proliferation is essential to reverse or slow down the heart failure progression in many cardiovascular diseases such as myocardial infarction (MI).
Kang Huang +9 more
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Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. [PDF]
PLoS ONE, 2013 Unlike its mammalian counterpart, the adult zebrafish heart is able to fully regenerate after severe injury. One of the most important events during the regeneration process is cardiomyocyte proliferation, which results in the replacement of lost ...
Ying Huang +7 more
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Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularization and Functional Recovery Despite Local Fibrosis [PDF]
Stem Cell Reports, 2018 Summary: So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms.
Vasco Sampaio-Pinto +13 more
doaj +2 more sources
Cell Communication and SignalingBackground The neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas mature cardiomyocytes withdraw from the cell cycle and lose regenerative capacities.
Chao Su +11 more
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KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway [PDF]
Advanced ScienceInnovative therapeutic approaches for heart failure, a leading cause of mortality worldwide, are urgently needed. In this study, the important role of Krüppel‐like factor 1 (KLF1) in cardiomyocyte proliferation and heart regeneration is explored, and ...
Yanglin Hao +19 more
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