Results 41 to 50 of about 801,889 (178)

Restoring Ravaged Heart: Molecular Mechanisms and Clinical Application of miRNA in Heart Regeneration

Frontiers in Cardiovascular Medicine, 2022
Human heart development is a complex and tightly regulated process, conserving proliferation, and multipotency of embryonic cardiovascular progenitors.
Vandit Shah, Jigna Shah
doaj   +1 more source

Dedifferentiation and Proliferation of Mammalian Cardiomyocytes

PLoS ONE, 2010
It has long been thought that mammalian cardiomyocytes are terminally-differentiated and unable to proliferate. However, myocytes in more primitive animals such as zebrafish are able to dedifferentiate and proliferate to regenerate amputated cardiac muscle.Here we test the hypothesis that mature mammalian cardiomyocytes retain substantial cellular ...
Yiqiang Zhang, Tao-Sheng Li, Shuo-Tsan Lee, Kolja A Wawrowsky, Ke Cheng, Giselle Galang, Konstantinos Malliaras, M Roselle Abraham, Charles Wang, Eduardo Marbán   +9 more
openaire   +4 more sources

Hypoxia Induces Cardiomyocyte Proliferation in Humans

JACC: Basic to Translational Science, 2020
The mammalian heart has a substantial regenerative capacity in the first few days of life mediated by cardiomyocyte proliferation; however, this capacity is lost shortly after birth ([1][1]). Transition from the embryonic to postnatal circulation results in a rapid and substantial increase in ...
Ahmed, Mahmoud S., Sadek, Hesham A.
openaire   +2 more sources

Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis

eLife, 2022
The regeneration potential of the mammalian heart is incredibly limited, as cardiomyocyte proliferation ceases shortly after birth. β-adrenergic receptor (β-AR) blockade has been shown to improve heart functions in response to injury; however, the ...
Masahide Sakabe, Michael Thompson, Nong Chen, Mark Verba, Aishlin Hassan, Richard Lu, Mei Xin   +6 more
doaj   +1 more source

Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration [PDF]

, 2022
In mammals, the physiological activation of the glucocorticoid receptor (GR) by glucocorticoids (GCs) promotes the maturation of cardiomyocytes during late gestation, but the effect on postnatal cardiac growth and regenerative plasticity is unclear ...
Rahul Shastry Patnala, Mauro Giacca, Francesca Pontis, Eldad Tzahor, Martina Mazzeschi, Nicola Pianca, Silvia Da Pra, Valentina Papa, Kfir Baruch Umansky, Luisa Iommarini, Carmen Miano, Giovanna Cenacchi, Luca Braga, Chiara Bongiovanni, Mattia Lauriola, Francesca Sacchi, Riccardo Tassinari, Gabriele D’Uva, Carlo Ventura, Roberto Rizzi, Elvira Pantano, Maila Chirivì, Anna Maria Porcelli, Nicola Pianca and Francesca Sacchi, Eldad Tzahor and Gabriele D’Uva   +24 more
core   +1 more source

Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1)

Biology, 2022
For heart regeneration purposes, embryonic stem cell (ES)-based strategies have been developed to induce the proliferation of cardiac progenitor cells towards cardiomyocytes.
Farhad Khosravi, Negah Ahmadvand, Maria Wartenberg, Heinrich Sauer   +3 more
doaj   +1 more source

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction [PDF]

, 2018
Cardiomyocyte proliferation stops at birth when the heart is no longer exposed to maternal blood and, likewise, to regulatory T cells (Tregs) that are expanded to promote maternal tolerance towards the fetus.
Costa A, Mauro Giacca, Pierro C, Martinelli, Valentina, Klatzmann, David, Cristina Pierro, Colliva A, Anzini M, Moimas S, Alessia Costa, Simone Vodret, Ellen Dirkx, Dirkx, Ellen, Colussi G, Giacca M, Michael Rehman, Zacchigna, Serena, Rehman M, Andrea Colliva, Andrea Nordio, Sinagra G, Silvia Moimas, Giacca, Mauro, Nordio A, David Klatzmann, Gutierrez, Maria, Ines, Long, Carlin, Rehman, Michael, Gutierrez, Maria Ines, Colliva, Andrea, Zacchigna S, Long C, Gianfranco Sinagra, Colussi, Giulia, Sinagra, Gianfranco, Valentina Martinelli, Klatzmann D, Carlin Long, Anzini, Marco, Moimas, Silvia, Maria Ines Gutierrez, Pierro, Cristina, Giulia Colussi, Vodret S, Martinelli V, Costa, Alessia, Nordio, Andrea, Serena Zacchigna, Zentilin L, Marco Anzini, Dirkx E, Gutierrez MI, Zentilin, Lorena, Vodret, Simone, Lorena Zentilin   +54 more
core   +1 more source

The Effects of Maternal Hypothyroidism on Postnatal Cardiomyocyte Proliferation and Cardiac Disease Responses of the Progeny

, 2023
The Effects of Maternal Hypothyroidism on Postnatal Cardiomyocyte Proliferation and Cardiac Disease Responses of the ...
Yijia Li (13971414)
core   +1 more source

Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Antisense long noncoding RNAs (lncRNAs) are single‐stranded RNAs that overlapped gene‐coding regions on the opposite DNA strand and play as critical regulators in cardiovascular diseases.
Bing Li, Yinlan Hu, Xinzhong Li, Guoqing Jin, Xiaoqiang Chen, Guojun Chen, Yanmei Chen, Senlin Huang, Wangjun Liao, Yulin Liao, Zhonghua Teng, Jianping Bin   +11 more
doaj   +1 more source

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

Nature Communications, 2023
The inability of adult human cardiomyocytes to proliferate is an obstacle to efficient cardiac regeneration after injury. Understanding the mechanisms that drive postnatal cardiomyocytes to switch to a non-regenerative state is therefore of great ...
Cornelis J. Boogerd, Ilaria Perini, Eirini Kyriakopoulou, Su Ji Han, Phit La, Britt van der Swaan, Jari B. Berkhout, Danielle Versteeg, Jantine Monshouwer-Kloots, Eva van Rooij   +9 more
doaj   +1 more source