Results 51 to 60 of about 801,889 (178)

Cardiomyocyte Proliferation [PDF]

Circulation Research, 2017
The inability of the adult heart to repair or regenerate is manifested in prevalent morbidity and mortality related to myocardial infarction and heart failure. Cardiomyocyte proliferation, especially after myocardial infarction or in the context of heart failure, has been an area of intense research by many investigators for decades.
openaire   +2 more sources

Cardiomyocyte-Specific Overexpression of Activated Yes-Associated Protein Modified-RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration. [PDF]

J Am Heart Assoc
Background The proliferative capacity of cardiomyocytes in adult mammalian hearts is far too low to replace the cells that are lost to myocardial infarction.
Wang Y, Wu Y, Jiang Y, Tan H, Guragain B, Nguyen T, Zhao J, Zhou Y, Nakada Y, Zhang J.   +9 more
europepmc   +2 more sources

In vivo analysis of cardiomyocyte proliferation during trabeculation

, 2018
Cardiomyocyte proliferation is crucial for cardiac growth, patterning and regeneration; however, few studies have investigated the behavior of dividing cardiomyocytes in vivo.
Rasouli, S., Mochizuki, Naoki, Nakajima, H., Ramadass, R., Rasouli, S. Javad, Dogra, D., Mochizuki, N., Stainier, D., Stainier, Didier Y. R., Gunawan, Felix, Uribe, V., Chiba, A., Ramadass, Radhan, Reischauer, Sven, Chiba, Ayano, Dogra, Deepika, Gunawan, F., Reischauer, S., Nakajima, Hiroyuki, Uribe, Veronica   +19 more
core   +1 more source

Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes

Physiological Reports, 2023
Though it is well known that mammalian cardiomyocytes exit cell cycle soon after birth, the mechanisms that regulate proliferation remain to be fully elucidated.
Shota Suzuki, Shota Tanaka, Yusuke Kametani, Ayaka Umeda, Kosuke Nishinaka, Kaho Egawa, Yoshiaki Okada, Masanori Obana, Yasushi Fujio   +8 more
doaj   +1 more source

Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart

Methodist DeBakey Cardiovascular Journal, 2023
Cardiovascular diseases are the number one cause of death worldwide and in the United States (US). Cardiovascular diseases frequently progress to end-stage heart failure, and curative therapies are extremely limited.
Daniel J. Garry, Jianyi (Jay) Zhang, Thijs Larson, Hesham A. Sadek, Mary G. Garry   +4 more
doaj   +1 more source

Mononuclear Diploidy at the Heart of Cardiomyocyte Proliferation [PDF]

Cell Stem Cell, 2017
Reporting in Nature Genetics, Patterson et al. (2017) show that adult mammalian hearts possess an innate capacity to regenerate, which depends on a small population of mononuclear diploid cardiomyocytes. These cells undergo karyokinesis and cytokinesis, raising the possibility that endogenous cardiac muscle cells can be stimulated to proliferate for ...
openaire   +2 more sources

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry [PDF]

, 2014
© The Author 2014. Aims Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities in the adult heart.
Bennett M., Mohun T., Bellusci S., Chao C., Sturny R., Rochais F., Mesbah K., Kelly R.   +7 more
core   +2 more sources

Newborn hypoxia/anoxia inhibits cardiomyocyte proliferation and decreases cardiomyocyte endowment in the developing heart: role of endothelin-1. [PDF]

PLoS ONE, 2015
In the developing heart, cardiomyocytes undergo terminal differentiation during a critical window around birth. Hypoxia is a major stress to preterm infants, yet its effect on the development and maturation of the heart remains unknown.
Alexandra N Paradis, Maresha S Gay, Christopher G Wilson, Lubo Zhang   +3 more
doaj   +1 more source

Cardiomyocyte proliferation at single-cell resolution

Di-san junyi daxue xuebao, 2022
Single-cell multi-omics sequencing is a new technology to accurately analyze cell heterogeneity and gene regulatory network at single-cell resolution, and provides a brand new perspective of pathway analysis on cell differentiation, interaction and ...
ZENG Chunyu, FU Wenbin
doaj   +1 more source

RETRACTED ARTICLE: REST regulates the cell cycle for cardiac development and regeneration

Nature Communications, 2017
Despite the importance of cardiomyocyte proliferation in cardiac development and regeneration, the mechanisms that promote cardiomyocyte cell cycle remain incompletely understood.
Donghong Zhang, Yidong Wang, Pengfei Lu, Ping Wang, Xinchun Yuan, Jianyun Yan, Chenleng Cai, Ching-Pin Chang, Deyou Zheng, Bingruo Wu, Bin Zhou   +10 more
doaj   +1 more source