Results 71 to 80 of about 801,889 (178)

Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development

iScience
Summary: Epigenetic regulation of heart development remains incompletely understood. Here we show that LSD1, a histone demethylase, plays a crucial role in regulating cardiomyocyte proliferation during heart development.
Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang   +14 more
doaj   +1 more source

Cardiomyocyte proliferation: remove brakes and push accelerators [PDF]

Cell Research, 2017
Adult mammalian hearts cannot repair by themselves after injury due to limited proliferation of cardiomyocytes; removal of cell cycle blocker and/or addition of drugs that boost proliferation of cardiomyocytes provide potential means to cardiac regeneration.
Lingjuan, He, Bin, Zhou
openaire   +2 more sources

Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI) [PDF]

, 2019
RATIONALE: Understanding and manipulating the cardiomyocyte cell cycle has been the focus of decades of research, however the ultimate goal of activating mitotic activity in adult mammalian cardiomyocytes remains elusive and controversial. The relentless
Avitabile, Daniele, Quijada, Pearl J, Chavarria, Monica, Moshref, Maryam, Gude, Natalie A, Monsanto, Megan M, Sussman, Mark A, Bailey, Barbara A, Ebeid, David, Siddiqi, Sailay, Wang, Bingyan J, Ho, Thi, Shaitrit, Maya, Alvarez, Roberto, Navarrete, Natalie, Firouzi, Fareheh, Broughton, Kathleen M   +16 more
core   +1 more source

Cardiomyocyte GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms

, 2021
Cardiomyopathy is an irreparable loss and novel strategies are needed to induce resident cardiac progenitor cell (CPC) proliferation in situ to enhance the possibility of cardiac regeneration.
Qaisar, Rizwan, Ahmad|, Woodgett, James R., Koch|, Jayakumar, Manju Nidagodu, Yusuf, Ayesha M., Ahmad, Firdos, Al-Tamimi, Abaher O., Koch, Walter   +8 more
core   +1 more source

Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals

Biomolecules, 2020
Cardiovascular disease is the leading cause of death worldwide. Current palliative treatments can slow the progression of heart failure, but ultimately, the only curative treatment for end-stage heart failure is heart transplantation, which is only ...
Lousanne de Wit, Juntao Fang, Klaus Neef, Junjie Xiao, Pieter A. Doevendans, Raymond M. Schiffelers, Zhiyong Lei, Joost P.G. Sluijter   +7 more
doaj   +1 more source

Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis

, 2022
Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Ming-Hui Zou, Jinfeng Ning, Ning, Jinfeng, Song, Ping, Tharmarajan Ramprasath, Donghong Zhang, Zheng, Xiaoxu, Xiaoxu Zheng, Zhonglin Xie, Zou, Ming-Hui, Ramprasath, Tharmarajan, Changjiang Yu, Xie, Zhonglin, Zhang, Donghong, Ping Song, Yu, Changjiang   +15 more
core   +1 more source

Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism

, 2017
Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development.
José Eduardo Krieger, Alicia Juliana Kowaltowski, Aline Alfonso Keusseyan, Maria Fernanda Forni, Ana Elisa Teófilo Saturi de Carvalho, Vinícius Bassaneze   +5 more
core   +1 more source

Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress

Journal of Cardiovascular Development and Disease
A sudden increase in ambient oxygen concentration after birth forces the metabolic switch from anaerobic glycolysis to oxidative phosphorylation, which contributes to the rapid decline of cardiomyocyte proliferation.
Mengfei Cao, Jie Luo, Kewei Fu, Yao Xu, Yinyu Wang, Junying Duan, Rui Chen, Wei Yuan   +7 more
doaj   +1 more source

Protocol to evaluate rat and mouse cardiomyocyte proliferation in vitro and in vivo. [PDF]

STAR Protoc
Summary: Here, we present a protocol for the quantitative assessment of rat and mouse cardiomyocyte proliferation both in vitro and in vivo. For the in vivo approach, we describe steps for the isolation of neonatal rat cardiomyocytes and the employment ...
Li B, Wei Y, Guo Y, Wang Q, Gu S, Ji X, Cao N.   +6 more
europepmc   +2 more sources

Tead1 is required for cardiomyocyte proliferation.

, 2019
(A, B) Cardiomyocyte proliferation (Ki67) and mitosis (phospho-Histone 3Ser10 positive immunostaining) in postnatal day 1 TeadF/F and Tead1-cKO hearts. (C, D) Quantitative analysis represents counting of multiple sections from three independent samples ...
Feng Li (30515), Rajaganapathi Jagannathan (104772), Byung S. Kim (3955703), Nikhil Balasubramanyam (6407207), Vijay K. Yechoor (389036), Mousumi Moulik (6407210), Ping Yang (56755), Jeongkyung Lee (389032), Ruya Liu (6407204)   +8 more
core   +1 more source