Results 81 to 90 of about 801,889 (178)

Mechanisms that drive cardiomyocyte proliferation during zebrafish heart regeneration

, 2014
Heart disease is the leading cause of death in the developed world. Adult mammals cannot replace lost cardiac tissue after injury, leading to reduced quality of life and increased instances of future cardiac issues.
Gemberling, Matthew P.
core  

miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1

, 2017
A limited number of microRNAs (miRNAs, miRs) have been reported to control postnatal cardiomyocyte proliferation, but their strong regulatory effects suggest a possible therapeutic approach to stimulate regenerative capacity in the diseased myocardium ...
Cretoiu, Dragos, Kong, Xiangqing, Joost PG Sluijter, Xiangqing Kong, Das, Saumya, Bei, Yihua, Sluijter, Joost PG, Li, Xinli, Hui Liu, Saumya Das, Nicolae Suciu, Xinli Li, Yihua Bei, Xiao, Junjie, Shi, Jing, Dragos Cretoiu, Suciu, Nicolae, Daniela Oana Toader, Junjie Xiao, Toader, Daniela Oana, Jing Shi, Liu, Hui, Shutong Shen, Shen, Shutong, Regenerative Medicine and Stem Cells, Onderzoek Cardiovasculair Reg. Med., Circulatory Health   +26 more
core   +1 more source

Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation

Acta Pharmaceutica Sinica B
The neonatal mammalian heart has a remarkable regenerative capacity, while the adult heart has difficulty to regenerate. A metabolic reprogramming from glycolysis to fatty acid oxidation occurs along with the loss of cardiomyocyte proliferative capacity ...
Luxun Tang, Yu Shi, Qiao Liao, Feng Wang, Hao Wu, Hongmei Ren, Xuemei Wang, Wenbin Fu, Jialing Shou, Wei Eric Wang, Pedro A. Jose, Yongjian Yang, Chunyu Zeng   +12 more
doaj   +1 more source

Modulation of TNFα Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration

iScience, 2019
Summary: The adult zebrafish is capable of regenerating heart muscle, resolving collagen tissue, and fully restoring heart function throughout its life. In this study, we show that the highly upregulated, epicardium-enriched microRNA let-7i functions in ...
Ashley M. Smith, Christina A. Dykeman, Benjamin L. King, Viravuth P. Yin   +3 more
doaj   +1 more source

Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation

, 2014
Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post-natal development.
Richard T. Lee, Samuel E. Senyo, Bernhard Kühn   +2 more
core   +1 more source

CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart [PDF]

, 2015
Cyclin dependent kinase (Cdk)9 acts through the positive transcription elongation factor-b (P-TEFb) complex to activate and expand transcription through RNA polymerase II. It has also been shown to regulate cardiomyocyte hypertrophy, with recent evidence
Denvir, Martin A., Maqsood, Sana, Mullins, John J., Tucker, Carl S., Matrone, Gianfranco, M. A. Denvir, Wilson, Kathryn S., G. Matrone, S. Maqsood, C. S. Tucker, K. S. Wilson, J. J. Mullins   +11 more
core   +1 more source

Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration.

, 2022
During the past two decades, the field of mammalian myocardial regeneration has grown dramatically, and with this expanded interest comes increasing claims of experimental manipulations that mediate bona fide proliferation of cardiomyocytes.
Huang, Guo N, Lough, John W, Kühn, Bernhard, Rosenthal, Nadia, Yutzey, Katherine E, O\u27Meara, Caitlin C, Payumo, Alexander Y, Han, Lu, Auchampach, John, Patterson, Michaela, Sucov, Henry M, Katherine E. Yutzey, Alexander Y. Payumo, Lu Han, Henry M. Sucov, Nadia A. Rosenthal, John Auchampach, John W. Lough, Caitlin C. O’Meara, Michaela Patterson, Bernhard Kühn, Guo N. Huang   +21 more
core   +1 more source

Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation

JCI Insight, 2023
The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates during the first week of life. Postnatal regeneration is mainly driven by proliferation of preexisting cardiomyocytes and supported by proregenerative
Galip S. Aslan, Nicolas Jaé, Yosif Manavski, Youssef Fouani, Mariana Shumliakivska, Lisa Kettenhausen, Luisa Kirchhof, Stefan Günther, Ariane Fischer, Guillermo Luxán, Stefanie Dimmeler   +10 more
doaj   +1 more source

Cardiomyocyte maturation and proliferation is a flip coin

BMC Cardiovascular Disorders
Cardiac regeneration offers a promising approach to treating ischemic heart disease. Accumulating evidence indicates that maturation limits the proliferative capacity of the adult myocardium. During cardiac development, cardiomyocytes (CMs) undergo genetic reprogramming, leading to maturation characterized by polyploid CMs, increased sarcomere rigidity,
Riham R. E. Abouleisa, Kamal Abou Farraj, Stuti G. Mehta, Tamer M. A. Mohamed   +3 more
openaire   +2 more sources

The Cytoskeletal Structure in Cardiomyocyte Maturation and Proliferation

Cells
The adult heart has a limited ability to regenerate, which is partly due to the structural and metabolic specialization that cardiomyocytes (CMs) acquire during postnatal maturation. In this review, we explore how cytoskeletal remodeling, metabolic reprogramming, and interactions with the extracellular matrix (ECM) regulate CM maturation, proliferation,
Aldana Rojas, Shelby Dahlen, Feng Zhang, Shijie Liu   +3 more
openaire   +2 more sources