Results 101 to 110 of about 801,889 (178)

Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity

, 2015
Rationale: Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. Thus, they are unable to effectively replace dying cells in the injured heart.
Gomez, Ludovic, Li, Jifen, Radice, G. L., Roslyn Yi, Vite, Alexia, Erhe Gao, Frans van Roy, Radice, Glenn L, Steven Goossens, Gao, E., Roy, F., Van, Gao, Erhe, Vite, A., Goossens, S., Glenn L. Radice, Goossens, Steven, Van Roy, Frans, Alexia Vite, Jifen Li, Li, J., Gomez, L., Yi, Roslyn, Yi, R., Ludovic Gomez   +23 more
core   +1 more source

Development of a Molecular Probe for Measuring Cardiomyocyte Proliferation

, 2018
Currently, one of the biggest controversies in the field of cardiac regenerative medicine revolves around the ability of cardiomyocytes to proliferate.
Kannan, Suraj
core   +1 more source

miR-199a-3p suppresses Vldlr expression to promote cardiomyocyte proliferation

Acta Biochimica et Biophysica Sinica
The proliferative capacity of cardiomyocytes is limited in adult mammals, and replacing lost tissue following acute ischemic injury is challenging. Previous studies have demonstrated that miR-199a-3p
Jiang Rui, Pei Lijuan, Zhang Hongjie, He Fenglian, Min Yuhan, Li Xinhang, Wei Ke   +6 more
doaj   +1 more source

α-Ketoglutarate promotes cardiomyocyte proliferation and heart regeneration after myocardial infarction

The neonatal mammalian heart can regenerate following injury through cardiomyocyte proliferation but loses this potential by postnatal day 7. Stimulating adult cardiomyocytes to reenter the cell cycle remains unclear.
Zhao, Xiaofang, Ren, Hongmei, Wu, Hao, Fu, Wenbin, Jose, Pedro A, Tian, Miao, Liao, Qiao, Li, Liangpeng, Zheng, Shuo, Wang, Feng, Zeng, Chunyu, Tang, Luxun, Shi, Yu   +12 more
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The whz mutation interferes with cardiomyocyte proliferation.

, 2016
(A, B) TUNEL stainings of embryonic zebrafish hearts at 72 hpf show no difference in the number of apoptotic cardiomyocytes in wt (A) and whz (B) mutant embryos. TUNEL positive cells in the pericardium (peri) and ventricles are marked by arrows.
Mirjam Keßler (3373205), Anja Bühler (2556937), Steffen Just (2556940), Linda Raphel (140428), Ina M. Berger (3373208), Wolfgang Rottbauer (106287)   +5 more
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Data on the gene expression of cardiomyocyte exposed to hypothermia

, 2016
Hypothermia is widely used in neurosurgery and cardiac surgeries. However, little is known about the underlying molecular mechanisms. We previously reported that the transcriptome responses of cardiomyocyte exposed to hypothermia, “The transcriptome ...
Jian Zhang, Huishan Wang, Xiaodong Xue, Yinli Xu, Yuji Zhang, Zhi Li   +5 more
core   +1 more source

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics

Scientific Reports
Connectin (also known as titin) is a giant striated muscle protein that functions as a molecular spring by providing elasticity to the sarcomere. Novex-3 is a short splice variant of connectin whose physiological function remains unknown.
Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri   +11 more
doaj   +1 more source

lncRNA Lockd promotes cardiomyocyte proliferation via Eno1/beta-catenin/Myc axis. [PDF]

Mol Ther Nucleic Acids
Prakash S, Kundu S, Chaudhary AD, Chaudhary S, Kumar C, Kumari S, Singh S, Yadav B, Kumar A, Prajapati VM, Jagavelu K, Kumar S, Gupta SK.   +12 more
europepmc   +1 more source

Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation. [PDF]

J Cell Biol
Liu H, Ammanamanchi N, Mich-Basso JD, Panama BK, Li Y, Huang W, Almeida D, Lewarchik CM, Lo B, Wu Y, Gotthardt M, Kotlikoff MI, Baehr W, Rasmusson R, Salama G, Kühn B.   +15 more
europepmc   +1 more source

Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation

Irreversible cardiac fibrosis, cardiomyocyte death and chronic cardiac dysfunction after myocardial infarction pose a substantial global health-care challenge, with no curative treatments available.
Regenerative Medicine and Stem Cells, Onderzoek Molecular Cardiology, Koopmans, Tim, Circulatory Health, van Rooij, Eva   +4 more
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