Results 71 to 80 of about 1,084,670 (306)

Machine learning to predict overall short-term mortality in cutaneous melanoma

Discover Oncology, 2023
Background Cutaneous malignant melanoma (CMM) ranks among the ten most frequent malignancies, clinicopathological staging being of key importance to predict prognosis.
C. Cozzolino, A. Buja, M. Rugge, A. Miatton, M. Zorzi, A. Vecchiato, P. Del Fiore, S. Tropea, A. Brazzale, G. Damiani, L. dall’Olmo, C. R. Rossi, S. Mocellin   +12 more
doaj   +1 more source

Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

Micromachines, 2021
Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration.
Ana Rita M. P. Santos, Yongjun Jang, Inwoo Son, Jongseong Kim, Yongdoo Park   +4 more
doaj   +1 more source

Model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and beta2-adrenergic stimulation [PDF]

, 2017
In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination.
Cornacchione, Marisa, Fassina, Lorenzo, Gimmelli, Roberto, Isidori, Andrea M, Lenzi, Andrea, Magenes, Giovanni, Mognaschi, MARIA EVELINA, Naro, Fabio, Pellegrini, Manuela   +8 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

ANALYSIS OF COLLAGEN PRODUCTION IN HYPERTROPHIC CARDIAC TISSUE OF RATS TREATED WITH L-NAME AND L-ARGININE BY IMAGE PROCESSING

Revista UniVap, 2019
We analyzed the production of collagen in the heart of hypertensive rats induced by L-name. Methods: Cardiac imaging of 5 groups: NT, hypertension induced by L-name, L-name and 10 mg L-arginine, L-name and 30 mg L-arginine and L-name and 100 mg L ...
Vanessa Oliveira Colombo Marson, Márcia Aparecida Silva Bissaco, Luciano Ramos, Silvia Cristina Martini Rodrigues, Romildo Torres Da Silva, Fernando Francisco Pazello Mafra, Michel Monteiro Macedo, Patrícia Sardinha Leonardo Lopes Martins, Rodrigo Alvaro Brandão Lopes Martins   +8 more
doaj   +1 more source

Interconnection between Cardiac Cachexia and Heart Failure—Protective Role of Cardiac Obesity

Cells, 2022
Cachexia may be caused by congestive heart failure, and it is then called cardiac cachexia, which leads to increased morbidity and mortality. Cardiac cachexia also worsens skeletal muscle degradation.
María Elena Soto, Israel Pérez-Torres, María Esther Rubio-Ruiz, Linaloe Manzano-Pech, Verónica Guarner-Lans   +4 more
doaj   +1 more source

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. [PDF]

, 2018
The extracellular matrix is a master regulator of tissue homeostasis in health and disease. Here we examined how the small, leucine-rich, extracellular matrix proteoglycan decorin regulates cardiomyocyte metabolism during fasting in vivo.
Gubbiotti, Maria A., Hoek, Jan B., Iozzo, Renato V., Rodeck, Ulrich, Seifert, Erin L.   +4 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Regional differences in APD restitution can initiate wavebreak and re-entry in cardiac tissue: A computational study [PDF]

, 2005
Background Regional differences in action potential duration (APD) restitution in the heart favour arrhythmias, but the mechanism is not well understood.
A Garfinkel, A Karma, A Panfilov, AT Winfree, BH van Huysduynen, C Antzelevitch, CS Kuo, D Noble, DW Frazier, EM Cherry, F Fenton, F Xie, FH Fenton, GK Moe, GX Yan, HN Pak, I Banville, J Han, JM Pastore, K Gima, K Yuuki, KJ Sampson, KJ Sampson, KR Laurita, KR Laurita, MA Watanabe, ML Riccio, MR Franz, P Taggart, P Taggart, PC Viswanathan, Peter Taggart, RH Clayton, RH Clayton, Richard H Clayton, SD Girouard, TJ Hund, ZL Qu   +37 more
core   +3 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source