Results 51 to 60 of about 719,635 (266)

Multicellular 3D models to study myocardial ischemia–reperfusion injury

Frontiers in Cell and Developmental Biology
Coronary heart disease is a major global health threat, with acute myocardial ischemia–reperfusion injury (IRI) being a major contributor to myocardial damage following an ischemic event.
Merel Peletier, Merel Peletier, Xiaohan Zhang, Xiaohan Zhang, Scarlett Klein, Scarlett Klein, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cardiac Tissue Response to Endotoxin.

Experimental Biology and Medicine, 1962
Summary And ConclusionAdministration of catechol amines together with endotoxin to normal rabbits results in a greater degree of inflammation and necrosis of cardiac muscle than is produced by either agent alone. The damage is prevented or markedly reduced by pretreatment with dibenamine.
C, PALMERIO, S C, MING, E D, FRANK, J, FINE   +3 more
openaire   +2 more sources

Geometric characteristics of bicuspid aortic valvesCentral MessagePerspective

JTCVS Techniques, 2021
Objective: We studied the coaptation angles α and β in bicuspid aortic valve geometry from computed tomography scan images. Methods: In 45 patients, we calculated the coaptation angle α (the angle between the nonfused commissures crossing the center of ...
Jan Nijs, MD, Babs Vangelder, MD, Kaoru Tanaka, MD PhD, Sandro Gelsomino, MD, PhD, FESC, Ines Van Loo, MD, Mark La Meir, MD, PhD, Jos Maessen, MD, PhD, Bas L.J.H. Kietselaer, MD, PhD   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mechanostimulation Protocols for Cardiac Tissue Engineering [PDF]

BioMed Research International, 2013
Owing to the inability of self-replacement by a damaged myocardium, alternative strategies to heart transplantation have been explored within the last decades and cardiac tissue engineering/regenerative medicine is among the present challenges in biomedical research.
GOVONI, MARCO, MUSCARI, CLAUDIO, GUARNIERI, CARLO, GIORDANO, EMANUELE DOMENICO   +3 more
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Recent advances in biological pumps as a building block for bioartificial hearts

Frontiers in Bioengineering and Biotechnology, 2023
The field of biological pumps is a subset of cardiac tissue engineering and focused on the development of tubular grafts that are designed generate intraluminal pressure.
Sunita Brimmer, Sunita Brimmer, Sunita Brimmer, Pengfei Ji, Pengfei Ji, Pengfei Ji, Aditya K. Birla, Aditya K. Birla, Sundeep G. Keswani, Sundeep G. Keswani, Sundeep G. Keswani, Sundeep G. Keswani, Christopher A. Caldarone, Christopher A. Caldarone, Christopher A. Caldarone, Christopher A. Caldarone, Ravi K. Birla, Ravi K. Birla, Ravi K. Birla, Ravi K. Birla, Ravi K. Birla   +20 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Machine learning to predict overall short-term mortality in cutaneous melanoma

Discover Oncology, 2023
Background Cutaneous malignant melanoma (CMM) ranks among the ten most frequent malignancies, clinicopathological staging being of key importance to predict prognosis.
C. Cozzolino, A. Buja, M. Rugge, A. Miatton, M. Zorzi, A. Vecchiato, P. Del Fiore, S. Tropea, A. Brazzale, G. Damiani, L. dall’Olmo, C. R. Rossi, S. Mocellin   +12 more
doaj   +1 more source