Results 41 to 50 of about 719,635 (266)

Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D–3D proteomics

Scientific Reports
Vascular smooth muscle cells (VSMCs) are regulators of vascular homeostasis and play a role in cardiovascular diseases, including atherosclerosis and aortic aneurysms.
Julia Hesse, Ulrike Resch, Lotte Görtz, Sarah Lang, Roya Batool, Sarah Saradar, Patricia Schoof, Kevin Gehlweiler, Daniela Zouikova, Pandora Jashnieh, Ricardo Fernandes Velosa, Nino Hotzel-Hacker, Fumitaka Suzuki, Samet Bayraktar, Melanie Cappallo, Vera Schmidt, Lara Ebbert, Margret H. Bülow, Nicole Kucharowski, Eija K. Laakkonen, Marcus Krüger, Gerhard Sengle, Alexandra Chadt, Artur Lichtenberg, Hug Aubin, Elvira Weber   +25 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review

Journal of Tissue Engineering, 2023
Severe tracheal injuries that cannot be managed by mobilization and end-to-end anastomosis represent an unmet clinical need and an urgent challenge to face in surgical practice; within this scenario, decellularized scaffolds (eventually bioengineered ...
Elena Stocco, Silvia Barbon, Marco Mammana, Giovanni Zambello, Martina Contran, Pier Paolo Parnigotto, Veronica Macchi, Maria Teresa Conconi, Federico Rea, Raffaele De Caro, Andrea Porzionato   +10 more
doaj   +1 more source

Large animal models for cardiac remuscularization studies: A methodological review

Frontiers in Cardiovascular Medicine, 2023
Myocardial infarction is the most common cause of heart failure, one of the most fatal non-communicable diseases worldwide. The disease could potentially be treated if the dead, ischemic heart tissues are regenerated and replaced with viable and ...
Yuexin Yu, Yuexin Yu, Yuexin Yu, Seng Kong Tham, Fatin Fazrina Roslan, Bakiah Shaharuddin, Yoke Keong Yong, Zhikun Guo, Zhikun Guo, Jun Jie Tan   +9 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Exploring Cardiac Exosomal RNAs of Acute Myocardial Infarction

Biomedicines
Background: Myocardial infarction (MI), often a frequent symptom of coronary artery disease (CAD), is a leading cause of death and disability worldwide.
Seung Eun Jung, Sang Woo Kim, Jung-Won Choi   +2 more
doaj   +1 more source

Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart

Frontiers in Physiology, 2018
Computational modeling is an important tool to advance our knowledge on cardiac diseases and their underlying mechanisms. Computational models of conduction in cardiac tissues require identification of parameters.
Joachim Greiner, Joachim Greiner, Aparna C. Sankarankutty, Aparna C. Sankarankutty, Gunnar Seemann, Gunnar Seemann, Thomas Seidel, Frank B. Sachse, Frank B. Sachse   +8 more
doaj   +1 more source

Massive primary cardiac synovial sarcoma of the left atrium: a case report

Journal of Cardiothoracic Surgery, 2022
Background Synovial sarcomas are tumors typically located in the extremities and characterized by a t(X;18)(p11.2;q11.2) chromosomal translocation. With only around 100 cases reported in the literature, cardiac synovial sarcomas are extremely rare.
Alice L. Zhou, Meghan E. Halub, John M. Gross, Benjamin L. Shou, Ahmet Kilic   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The Strength-Interval Curve in Cardiac Tissue [PDF]

Computational and Mathematical Methods in Medicine, 2013
The bidomain model describes the electrical properties of cardiac tissue and is often used to simulate the response of the heart to an electric shock. The strength-interval curve summarizes how refractory tissue is excited. This paper analyzes calculations of the strength-interval curve when a stimulus is applied through a unipolar electrode.
Sunil M. Kandel, Bradley J. Roth
openaire   +3 more sources