Results 161 to 170 of about 39,995 (259)

Reducing ROS Production in Mitochondria via Cardiolipin

Cardiolipin is a peculiar dimeric phospholipid that is localized primarily in the inner mitochondrial membrane, in which it plays a pivotal role in maintaining the structural and functional integrity of the electron transport chain (ETC).
Alshehri, Saleh, Dubal, Dnyanesh
core   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Mitochondrial respiratory supercomplexes associated with longevity in mammals. [PDF]

Front Aging
Suzuki S, Ikeda K, Takeiwa T, Horie K, Inoue S.   +4 more
europepmc   +1 more source

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework. [PDF]

Int J Mol Sci
Lee CL, Chuang CK, Chang YH, Chiu HC, Tu YR, Lo YT, Wu JY, Huang HY, Lin HY, Lin SP.   +9 more
europepmc   +1 more source

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging

Aging Cell, Volume 25, Issue 10, October 2026.
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang, Yue Wang, Caizhu Wang, Xin Guo, Huanhua Chen, Yu‐Xuan Hou, Xuan Wu, Zi‐Jian Wu, Wen‐Lin Pan, Rui‐Jie Ma, Ping‐Shuang Lu, Jinhui Shu, Shao‐Chen Sun   +12 more
wiley   +1 more source

Neonatal Hypoxic-Ischemic Encephalopathy: From the Limitations of Therapeutic Hypothermia to Precision Intervention. [PDF]

Drug Des Devel Ther
Yang T, Zhu C, Sun H, Yao X, Liu G.
europepmc   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, Volume 293, Issue 20, Page 6253-6271, October 2026.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

Circulating Extracellular Mitochondria Perpetuate Endothelial Damage via Cardiolipin-Mediated Mitophagic Overload. [PDF]

Arterioscler Thromb Vasc Biol
Varzideh F, Kansakar U, Pande S, Jankauskas SS, Santulli G.   +4 more
europepmc   +1 more source

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 1181-1188, October 2026.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli, Arianna Gatti, Flora Ierna, Elena Riccardi, Irene Cuppari   +4 more
wiley   +1 more source