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A preliminary report on the feasibility of regression-based alignment of diagnostic thresholds for harmonized use of international classification criteria for antiphospholipid syndrome. [PDF]
PLoS OneMotoki Y +8 more
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Mitochondrial Dysfunction in Cardiomyopathy and Heart Failure: From Energetic Collapse to Therapeutic Opportunity. [PDF]
BiomoleculesPavlović N +6 more
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Photoreactive cardiolipin analogues
Chemistry and Physics of Lipids, 1988New photoreactive analogues of cardiolipin have been chemically synthesized. Photoreactive aryl azido acyl groups were placed at two different locations within the cardiolipin molecule: at the 2-sn position of the 2-sn glycerol of cardiolipin; at the 2-sn position of the 3-sn-phosphatidyl group; or at both locations to provide a dual labeled analogue ...
W T, Fowler, J D, Lambeth, G L, Powell
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Cardiolipin (CL) is recognized to be an essential phospholipid in eukaryotic energy metabolism so that physiological and pathological perturbations in its synthetic and catabolic pathways play key roles in maintaining mitochondrial structure and function, and ultimately cell survival.
Jeanie B, McMillin, William, Dowhan
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Cardiolipin (CL) is recognized to be an essential phospholipid in eukaryotic energy metabolism so that physiological and pathological perturbations in its synthetic and catabolic pathways play key roles in maintaining mitochondrial structure and function, and ultimately cell survival.
Jeanie B, McMillin, William, Dowhan
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Mammalian cardiolipin biosynthesis
Chemistry and Physics of Lipids, 2014Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis ...
Edgard M, Mejia +2 more
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Cardiolipin synthase from yeast
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997Cardiolipin synthase catalyzes the synthesis of the mitochondrial phospholipid cardiolipin. Cardiolipin synthase is a unique membrane-bound enzyme in that it utilizes two phospholipids, both insoluble in water, as substrates. Kinetic analysis suggests that the enzyme forms a ternary complex with the two lipid substrates, and that a divalent metal ion ...
M, Schlame, M L, Greenberg
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Cholesterol effects on the interaction of cardiolipin with anti-cardiolipin antibody
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1987Human antibodies to cardiolipin, phosphatidic acid and phosphatidylserine were assessed by binding to nitrocellulose paper and subsequent reaction with an enzyme-linked or radioactively labelled second antibody to human IgG. The addition of cholesterol to constant amounts of cardiolipin impregnated in the nitrocellulose paper resulted in a profound ...
P B, Costello, F A, Green
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Cardiolipin-Mediated Cellular Signaling
2013This review focuses on recent studies showing that cardiolipin (CL), a unique mitochondrial phospholipid, regulates many cellular functions and signaling pathways, both inside and outside the mitochondria. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates signaling events related to ...
Vinay A, Patil, Miriam L, Greenberg
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