Results 251 to 260 of about 66,906 (291)
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Cardiolipin synthase from yeast
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997Cardiolipin synthase catalyzes the synthesis of the mitochondrial phospholipid cardiolipin. Cardiolipin synthase is a unique membrane-bound enzyme in that it utilizes two phospholipids, both insoluble in water, as substrates. Kinetic analysis suggests that the enzyme forms a ternary complex with the two lipid substrates, and that a divalent metal ion ...
M, Schlame, M L, Greenberg
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Cardiolipin remodeling in Barth syndrome and other hereditary cardiomyopathies.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020Mitochondria play a prominent role in cardiac energy metabolism, and their function is critically dependent on the integrity of mitochondrial membranes.
E. Bertero +3 more
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The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2019Mitochondria play an essential role in the energy metabolism of the heart. Many of the essential functions are associated with mitochondrial membranes and oxidative phosphorylation driven by the respiratory chain.
Jan Dudek, Magnus Hartmann, P. Rehling
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Curvature-Dependent Binding of Cytochrome c to Cardiolipin.
Journal of the American Chemical Society, 2020Cytochrome c binds cardiolipin on the concave surface of the inner mitochondrial membrane, before oxidizing the lipid and initiating the apoptotic pathway.
Margaret M. Elmer-Dixon +4 more
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Bacillus subtilis cardiolipin protects its own membrane against surfactin-induced permeabilization.
Biochimica et Biophysica Acta - Biomembranes, 2020Surfactin, a cyclic lipoheptapeptide produced by Bacillus subtilis, is a surface-active antimicrobial that targets the barrier function of lipid membranes. It inserts itself into the membrane, where it forms conductive pores.
D. Pinkas +6 more
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Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes.
ACS Chemical Neuroscience, 2019Aggregation of the amyloid-forming α-synuclein (αS) protein is closely associated with the etiology of Parkinson's disease (PD), the most common motor neurodegenerative disorder.
Stephanie Ghio +11 more
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Cholesterol effects on the interaction of cardiolipin with anti-cardiolipin antibody
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1987Human antibodies to cardiolipin, phosphatidic acid and phosphatidylserine were assessed by binding to nitrocellulose paper and subsequent reaction with an enzyme-linked or radioactively labelled second antibody to human IgG. The addition of cholesterol to constant amounts of cardiolipin impregnated in the nitrocellulose paper resulted in a profound ...
P B, Costello, F A, Green
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Cardiolipin-Mediated Cellular Signaling
2013This review focuses on recent studies showing that cardiolipin (CL), a unique mitochondrial phospholipid, regulates many cellular functions and signaling pathways, both inside and outside the mitochondria. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates signaling events related to ...
Vinay A, Patil, Miriam L, Greenberg
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Extracellular cardiolipin regulates select immune functions of microglia and microglia-like cells.
Brain Research Bulletin, 2019Cardiolipin is a mitochondrial membrane phospholipid with several well-defined metabolic roles. Cardiolipin can be released extracellularly by damaged cells and has been shown to affect peripheral immune functions.
Caitlin B. Pointer +2 more
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