Results 121 to 130 of about 3,383 (226)

The molecular basis of mitochondrial crista formation by the MIC10 complex. [PDF]

Sci Adv
Brown CM, Wassenaar TA, Freyberg Z, Marrink SJ.   +3 more
europepmc   +1 more source

Broccoli Sprout Extract Restores Renal Lipid Metabolism in High‐Fat Diet‐Fed Mice Involving Modulation of AMPK/Nrf2 Signaling and the NLRP3 Inflammasome

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
High‐fat diet (HFD) induces renal lipid accumulation, AMPK suppression, oxidative stress, and NLRP3 inflammasome activation, leading to renal injury. Broccoli sprout extract (BSE) concurrently activates AMPK signaling (promoting fatty acid oxidation and inhibiting lipogenesis), enhances Nrf2‐mediated antioxidant defense, and suppresses NLRP3‐driven ...
Chunting Wu, Bangzhao Zeng, Xuexun Li, Xin Zhao, Junyu Ma, Mengxue Zhang, Shuangshuang Zhao, Chunmei Zhang, Qin Gao, Fuli Ya   +9 more
wiley   +1 more source

The biochemical and metabolic adaptations underpinning the health benefits of exercise. [PDF]

J Sport Health Sci
Murphy RM, Febbraio MA.
europepmc   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction. [PDF]

J Clin Invest
Kim CW, Vale G, Fu X, McDonald JG, Dai C, Li C, Wang ZV, Sharma G, Khemtong C, Malloy CR, Deja S, Burgess SC, Mitsche MA, Horton JD.   +13 more
europepmc   +1 more source

Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1307-1323, September 2026.
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley   +1 more source

Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein-Deficient Mice and Human Fibroblasts. [PDF]

J Inherit Metab Dis
Vieira Neto E, Wang M, Szuminsky AJ, Ferraro L, Basu S, Zhao X, Karunanidhi A, Wang Y, Vockley J.   +8 more
europepmc   +1 more source

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Small extracellular vesicle (sEV) lipid profiles outperform CA‐125 across ovarian cancer histotypes, achieving accuracy up to 0.73 in differential diagnosis and 0.94 in screening. In patients with normal CA‐125 levels, sEV lipids maintain discriminative performance where CA‐125 alone fails. ABSTRACT Ovarian cancer remains the most lethal gynaecological
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon   +11 more
wiley   +1 more source

Immuno-metabolic dysregulation in type 2 diabetes is associated with altered neutrophil functional plasticity, mitochondrial dysfunction, and compromised responses in sepsis. [PDF]

J Transl Med
Ganesh K, Gomes SM, Vasishta S, Poojary G, Thimmappa PY, Peesapati S, Kabekkodu SP, Mallya S, Guruprasad KP, Singh A, Umakanth S, Chakraborty S, Joshi MB.   +12 more
europepmc   +1 more source

Treatment of Fatty Acid Oxidation Disorders Today: Emerging Personalized Treatment Strategies

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT The first international guideline on treatment and management of long‐chain fatty acid oxidation disorders has been published and demonstrates little scientific evidence for many of the treatment decisions. However, it is a substantial achievement to harmonize treatment and to define the remaining challenges.
U. Spiekerkoetter, J. Vockley
wiley   +1 more source