Results 161 to 170 of about 8,226 (286)
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang +10 more
wiley +1 more source
Thrombophilia in children with diffuse connective tissue disorders as systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM) could arise from various causes including peripherial blood circulation of antiphospholipid antibodies (APH) and ...
O.A. Solntseva
doaj +2 more sources
Investigation of the Physiochemical Properties of the Phospholipid Cardiolipin: Implications for Oxphos Regulation and Barth Syndrome [PDF]
Murugappan Sathappa +2 more
openalex +1 more source
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Research Progress of Ferroptosis in Cerebral Infarction
Cerebral infarction triggers ischemia–reperfusion injury, leading to iron overload, oxidative stress, and mitochondrial dysfunction, which together initiate ferroptosis—an iron‐dependent, lipid peroxidation–driven form of neuronal death. Disruption of the System Xc−/GSH/GPX4 antioxidant axis and ACSL4‐mediated PUFA phospholipid enrichment accelerates ...
Yilan Fei, Qi Leng
wiley +1 more source
Revisiting Coley's Toxins: Immunogenic Cardiolipins from Streptococcus pyogenes. [PDF]
Shin YH +7 more
europepmc +1 more source
The Role of Phosphatidic Acid and Cardiolipin in Stability of the Tetrameric Assembly of Potassium Channel KcsA [PDF]
Mobeen Raja
openalex +1 more source
Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation
Spatial proteomics provides high‐resolution maps of protein localization and trafficking by combining advanced mass spectrometry with complementary imaging and computational tools. Emerging low‐input and automated workflows are expanding its applicability to challenging clinical samples, supporting mechanistic disease research and biomarker discovery ...
Chiara Bernardini +2 more
wiley +1 more source
Role of cardiolipin in Shigella flexneri pathogensis
Rachael Madlyn Rossi
openalex +2 more sources

