Results 81 to 90 of about 3,234 (169)

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

Catastrophic Antiphospholipid Syndrome in a Young Female Complicated by Systemic Lupus Erythematosus and Left Atrial Myxoma: A Rare Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Catastrophic antiphospholipid syndrome (CAPS) is a fulminant and rare variant of antiphospholipid syndrome characterized by rapidly progressive multiorgan thrombosis and a high mortality rate. Its diagnosis is often challenging due to overlapping clinical features with sepsis, thromboembolic disorders, and systemic autoimmune diseases.
Nazmin Ahmed, Mohammad Nazrul Hossain, Abdullah Salman, Sabrina Yesmin, S. M. G. Saklayen   +4 more
wiley   +1 more source

Syncope as the Initial Presentation of Takayasu Arteritis in a 57‐Year‐Old Female: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Takayasu arteritis (TA) is a rare chronic granulomatous large‐vessel vasculitis predominantly affecting the aorta and its major branches, leading to stenosis, occlusion, or aneurysm formation. It typically presents in young women, though atypical cases can occur in older adults.
Chao Liu, Jiale Gan, Lili Feng, Yang Yang, Lianwei Dong, Jiabao Liu, Dingguo Zhang   +6 more
wiley   +1 more source

RASGRP1 Deficiency Manifesting as Severe Vasculopathy and Fatal Autoimmune Hemolytic Anemia

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Background RASGRP1 deficiency is a rare inborn error of immunity characterized by immunodeficiency, autoimmunity, and lymphoproliferation. Results We report a 5‐year‐old male with novel homozygous splice‐donor mutations in RASGRP1(c.1720+1G>A and c.1720+2T>C) who presented with severe vasculopathy (ischemic stroke and thrombosis), secondary ...
Kosar Asna Ashari, Bahareh Yaghmaie, Neda Pak, Mohammad Shahrooei, Vahid Ziaee, Nima Parvaneh   +5 more
wiley   +1 more source

Influence of diet-induced obesity and voluntary exercise training on cardiac lipids and mitochondrial function in mice

Journal of Sport and Health Science
Background: Obesity is a risk factor for developing cardiometabolic disease. Exercise training is pivotal in the treatment of obesity and is associated with reduced cardiovascular mortality.
Nimna Perera, Minh Deo, Surafel Tegegne, Yow Keat Tham, Natalie A. Mellett, Anida Velagic, Alex M. Parker, Oliver K. Fuller, Lauren V. Terry, Casey L. Egan, Peter J. Meikle, Rebecca H. Ritchie, Mark A. Febbraio, Miles J. De Blasio   +13 more
doaj   +1 more source

Venous Thromboembolism (VTE) Risk Stratification in Otolaryngology: Socioeconomic and Subspecialty Insights

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Objective Venous thromboembolism (VTE) is a leading cause of preventable perioperative mortality in otolaryngology, highlighting the urgent need for validated risk assessments such as the Caprini score to guide prophylaxis and enhance patient safety.
Corinne A. Pittman, Hudson Liu, Lovedeep Singh, Serenity G. Budd, Sabrina Heman‐Ackah, Selena E. Briggs   +5 more
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Sketching microprotein portraits

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The illustrations of intricate molecular machineries inside cells created by David Goodsell continue to inspire the scientific community. Here, we aim to extend his artworks to include microproteins, a newly recognized class of small proteins with less than 100 amino acids, encoded by small open reading frames.
Gabriel Diaz, Philippe Valenti, Marc Gueroult, Simon Marques‐Prieto, Kenza Benachenhou, Jennifer Zanet, Matthieu Chavent   +6 more
wiley   +1 more source