Results 81 to 90 of about 4,826 (241)
A comprehensive review of cancer‐induced cardiac wasting
British Journal of Pharmacology, EarlyView.Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena +5 more
wiley +1 more source
Multilayered lipid membrane stacks for biocatalysis using membrane enzymes [PDF]
, 2017 Multilayered or stacked lipid membranes are a common principle in biology and have various functional advantages compared to single lipid membranes, such as their ability to spatially organize processes, compartmentalize molecules and greatly increase ...
Butt, JN +7 more
core +2 more sources
Subcellular organelle lipidomics in TLR-4-activated macrophages1[S]
Journal of Lipid Research, 2010 Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual ...
Alexander Y. Andreyev +18 more
doaj +1 more source
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions [PDF]
, 2013 Mitochondria are arbiters in the fragile balance between cell life and death. These organelles present an intricate membrane system, with a peculiar lipid composition and displaying transverse as well as lateral asymmetry.
Jurado, A. S. +2 more
core +1 more source
Dysfunctional copper homeostasis in Caenorhabditis elegans affects genomic and neuronal stability
Redox Biochemistry and ChemistryWhile copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health.
Ann-Kathrin Weishaupt +9 more
doaj +1 more source
Focal Targeting of the Bacterial Envelope by Antimicrobial Peptides
Frontiers in Cell and Developmental Biology, 2016 Antimicrobial peptides (AMPs) are utilized by both eukaryotic and prokaryotic organisms. AMPs such as the human beta defensins, human neutrophil peptides, human cathelicidin, and many bacterial bacteriocins are cationic and capable of binding to anionic ...
Rafi eRashid +2 more
doaj +1 more source
The FEBS Journal, EarlyView.DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam +4 more
wiley +1 more source
Cardiolipin‐dependent Carriers
The FASEB Journal, 2021 The phospholipid, cardiolipin, has pleiotropic structural and functional roles that are collectively essential for mitochondrial biology. Yet, the molecular details of how this lipid supports the structure and function of proteins and protein complexes is poorly understood.
openaire +1 more source
Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging [PDF]
, 2016 Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption
Brown, R +11 more
core +1 more source