Results 41 to 50 of about 4,979,977 (315)

Identification of Key Genes as Early Warning Signals of Acute Myocardial Infarction Based on Weighted Gene Correlation Network Analysis and Dynamic Network Biomarker Algorithm

Frontiers in Immunology, 2022
PurposeThe specific mechanisms and biomarkersunderlying the progression of stable coronary artery disease (CAD) to acute myocardial infarction (AMI) remain unclear.
Chenxi Song, Chenxi Song, Zheng Qiao, Zheng Qiao, Luonan Chen, Jing Ge, Rui Zhang, Rui Zhang, Sheng Yuan, Sheng Yuan, Xiaohui Bian, Xiaohui Bian, Chunyue Wang, Chunyue Wang, Qianqian Liu, Qianqian Liu, Lei Jia, Lei Jia, Rui Fu, Rui Fu, Kefei Dou, Kefei Dou   +21 more
doaj   +1 more source

Targeting the vasculature in cardiometabolic disease

Journal of Clinical Investigation, 2022
Obesity has reached epidemic proportions and is a major contributor to insulin resistance (IR) and type 2 diabetes (T2D). Importantly, IR and T2D substantially increase the risk of cardiovascular (CV) disease. Although there are successful approaches to maintain glycemic control, there continue to be increased CV morbidity and mortality associated with
Nabil E. Boutagy, Abhishek K. Singh, William C. Sessa   +2 more
openaire   +3 more sources

Uric acid and cardiometabolic diseases [PDF]

Clinical Hypertension, 2020
AbstractHyperuricemia, which has been considered as a cause of gout and nephrolithiasis has recently been suggested to be associated with hypertension, coronary heart disease, heart failure, atrial fibrillation, insulin resistance, and nonalcoholic fatty liver disease.
Seung Jae Lee, Byeong Kil Oh, Ki-Chul Sung   +2 more
openaire   +3 more sources

Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. [PDF]

, 2013
Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the
Kumari, Meena, Price, Jacqueline, Cooper, Jackie, White, Jon, Power Christine, Stela McLachlan, Jorgen Engmann (448064), Ebrahim, S, Cooper Jackie, Davies, Teri-Louise, Yoav Ben-Shlomo, Elina Hypponen (2826818), Engmann Jorgen, Ebrahim, Shah, Kumari, M, Ong Ken, Sofat Reecha, Juan P Casas, Ian N. Day (448074), Davies, T-L, Ken Ong (448067), UCLEB Consortium,, Whincup Peter, Fotios Drenos (113686), Cavadino, Alana, Drenos, F, Langenberg, C, Jacqueline Price, Holmes Michael V., Price, J, Jon White, Helen Warren (448069), Jackie Cooper (448071), Kivimaki, Mika, McLachlan, Stela, Sofat, R, Langenberg, Claudia, Hypponen, Elina, Humphries, Steve E, Strachan, Mark W J, Power, Christine, Cavadino, A, Giambartolomei, C, Kuh, Diana, Rebecca Hardy (188906), White, J, Finan Chris, Casas Juan P., Richards Marcus, Diana Kuh, Shah, Sonia, Tom Gaunt (448068), Holmes, Michael V., Christine Power (448073), Dale, C, Talmud, Philippa J., Day, IN, Mika Kivimaki (2222011), Drenos, Fotios, Kuh Diana, Peter Whincup (20840), Peter Whincup, Lawlor Debbie A., Cavadino Alana, Richards, M, Hingorani, AD, Shah Sonia, Dale, Caroline, Whittaker, JC, Shah Ebrahim, McLachlan, S, Zabaneh Delilah, Dale Caroline, Tom Gaunt, Engmann, J, Reecha Sofat (448072), Debbie A. Lawlor (95270), Antoinette Amuzu, Shah, Tina, Holmes, MV, Plagnol, V, ?, ?, Richard Morris, Sonia Shah (142603), Lawlor, DA, Zabaneh, Delilah, Hypponen Elina, Wareham Nicholas, Davies, TL, Strachan, MW, Rebecca Hardy, Jon White (44386), Delilah Zabaneh (55672), John C Whittaker, Hardy Rebecca, Holmes, Michael V, Reecha Sofat, Dudbridge Frank, Teri-Louise Davies (448070), Swerdlow, Daniel I, Frank Dudbridge, Hingorani Aroon D., Andrew Wong (256256), Claudia Giambartolomei (142605), Sofat, Reecha, Nicholas Wareham, John C. Whittaker (51412), Morris Richard, Fotios Drenos, Talmud, Philippa J, Lawlor, Debbie A., Amuzu, A, Kuh, D, Warren Helen, Debbie A Lawlor, Mark W. J. Strachan (309411), Stela McLachlan (156093), Gaunt Tom, Hardy, R, Ong, K, McLachlan Stela, Shah Tina, UCLEB Consortium, Caroline Dale, Plagnol, Vincent, Claudia Langenberg, Michael V Holmes, Caroline Dale (448065), Kumari Meena, Andrew Wong, Steve E Humphries, Wong, A, Meena Kumari (95278), Shah, T, Giambartolomei Claudia, Giambartolomei, Claudia, Shah, S, Alana Cavadino (448066), Shah Ebrahim (27162), Antoinette Amuzu (353284), Whincup, P, Daniel I Swerdlow, Amuzu, Antoinette, Day Ian N., Vincent Plagnol, Whittaker, John C, Marcus Richards, Jacqueline Price (448075), Ben-Shlomo, Yoav, Jorgen Engmann, Tina Shah (256447), Power, C, Lawlor, Debbie A, Ong, Ken, Caulfield, Mark, Drenos Fotios, Tina Shah, Alana Cavadino, Wong Andrew, Kivimaki Mika, Gaunt, T, Teri-Louise Davies, Yoav Ben-Shlomo (95286), Aroon D. Hingorani (142610), Strachan, MWJ, Casas, Juan P, Philippa J Talmud, Strachan, Mark WJ, Plagnol Vincent, Elina Hypponen, Marcus Richards (306829), Engmann, Jorgen, Casas, JP, Cooper, J, Dudbridge, F, Michael V. Holmes (256443), Caulfield, M, Talmud, PJ, Nicholas Wareham (153226), Finan, Chris, Richards, Marcus, Mika Kivimaki, Gaunt, Tom, Humphries, SE, Aroon D Hingorani, Whittaker John C., Meena Kumari, Juan P. Casas (102298), Jackie Cooper, Ben-Shlomo, Y, Caulfield Mark, Steve E. Humphries (142616), Strachan Mark W. J., Sonia Shah, White Jon, Hardy, Rebecca, Consortium, UCLEB, Helen Warren, Davies Teri-Louise, Ken Ong, Hingorani, Aroon D, Price, Jacqueline; id_orcid, Talmud Philippa J., Hypponen, E, Price Jacqueline, Warren, H, Warren, Helen, Zabaneh, D, Finan, C, Day, Ian N, Chris Finan (155150), Mark W J Strachan, Morris, Richard, Delilah Zabaneh, Amuzu Antoinette, Claudia Giambartolomei, Vincent Plagnol (50600), Mark Caulfield, Wareham, N, Philippa J. Talmud (142613), Whincup, Peter, Dudbridge, Frank, Swerdlow, DI, Humphries Steve E., Wareham, Nicholas, Mark Caulfield (262145), Wong, Andrew, Morris, R, Kivimaki, M, Chris Finan, Christine Power, Ian N Day, Humphries, Steve E., Ben-Shlomo Yoav, Diana Kuh (188923), Richard Morris (188011), Frank Dudbridge (102283), Ebrahim Shah, Engmann, J., Dale, C., Wong, A., Warren, H., Holmes, M., Finan, C., Zabaneh, D., Gaunt, T., et al., Shah, S., Davies, T., Shah, T., Giambartolomei, C., Drenos, F., Cavadino, A., Amuzu, A., Ong, K., Cooper, J., Sofat, R., McLachlan, S., White, J.   +258 more
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Hypertension pathophysiology and relevance to the cardiometabolic syndrome

, 2023
High blood pressure, or hypertension, is the leading single risk factor for the global burden of disease. Hypertension often coexists with several anthropometric and metabolic abnormalities, including abdominal obesity, dyslipidemia, and glucose ...
Climie, Rachel E.D.,, Nilsson, Peter M.,, Lund University.   +2 more
core   +1 more source

Gallstones: a sentinel presentation of cardiometabolic disease

, 2023
Gallstone disease is one of the most common surgically-managed conditions worldwide yet associations with other medical conditions outside of the biliary tree are poorly understood.
Fairfield, Cameron James
core   +1 more source

Development and Validation of a Nomogram for Predicting the Risk of Adverse Cardiovascular Events in Patients with Coronary Artery Ectasia

Journal of Cardiovascular Development and Disease, 2021
Coronary artery ectasia (CAE) is a rare finding and is associated with poor clinical outcomes. However, prognostic factors are not well studied and no prognostication tool is available.
Zhongxing Cai, Yintang Wang, Luqi Li, Haoyu Wang, Chenxi Song, Dong Yin, Weihua Song, Kefei Dou   +7 more
doaj   +1 more source

Intensified glycemic control by HbA1c for patients with coronary heart disease and Type 2 diabetes: a review of findings and conclusions

Cardiovascular Diabetology, 2023
The occurrence and development of coronary heart disease (CHD) are closely linked to fluctuations in blood glucose levels. While the efficacy of intensified treatment guided by HbA1c levels remains uncertain for individuals with diabetes and CHD, this ...
Jingyang Chen, Dong Yin, Kefei Dou
doaj   +1 more source

Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomizationResearch in context

EClinicalMedicine, 2023
Summary: Background: Social isolation and loneliness pose significant public health challenges globally. The objective of this study is to investigate the association between social isolation, loneliness, and the risk of type 2 diabetes mellitus (T2DM).
Yanjun Song, Chen Zhu, Boqun Shi, Chenxi Song, Kongyong Cui, Zhen'ge Chang, Guofeng Gao, Lei Jia, Rui Fu, Qiuting Dong, Lei Feng, Chenggang Zhu, Dong Yin, JoAnn E. Manson, Kefei Dou   +14 more
doaj   +1 more source

Histone Deacetylases and Cardiometabolic Diseases [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
Cardiometabolic disease, emerging as a worldwide epidemic, is a combination of metabolic derangements leading to type 2 diabetes mellitus and cardiovascular disease. Genetic and environmental factors are linked through epigenetic mechanisms to the pathogenesis of cardiometabolic disease.
Kan Hui, Yiew, Tapan K, Chatterjee, David Y, Hui, Neal L, Weintraub   +3 more
openaire   +2 more sources