Results 21 to 30 of about 153,127 (306)

Glucagon receptor antagonism induces increased cholesterol absorption[S]

Journal of Lipid Research, 2015
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia.
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang   +22 more
doaj   +1 more source

Landscape of cardiometabolic risk factors in Chinese population: a narrative review

Cardiovascular Diabetology, 2022
With rapid economic growth and changes at all levels (including environmental, social, individual), China is facing a cardiovascular disease (CVD) crisis. In China, more than 40% of deaths are attributable to CVDs, and the number of CVD deaths has almost
Jian-Jun Li, Hui-Hui Liu, Sha Li
doaj   +1 more source

Prognostic value of N-terminal Pro–B-Type natriuretic peptide in patients with intermediate coronary lesions

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe optimal treatment strategy for patients with coronary intermediate lesions, defined as diameter stenosis of 50–70%, remains a great challenge for cardiologists.
Chenxi Song, Chenxi Song, Sheng Yuan, Sheng Yuan, Kongyong Cui, Kongyong Cui, Zhongxing Cai, Zhongxing Cai, Rui Zhang, Rui Zhang, Jining He, Jining He, Zheng Qiao, Zheng Qiao, Xiaohui Bian, Xiaohui Bian, Shaoyu Wu, Shaoyu Wu, Haoyu Wang, Haoyu Wang, Rui Fu, Rui Fu, Chunyue Wang, Chunyue Wang, Qianqian Liu, Qianqian Liu, Dong Yin, Dong Yin, Lei Jia, Lei Jia, Kefei Dou, Kefei Dou   +31 more
doaj   +1 more source

Associations between cardiorespiratory fitness, physical activity and clustered cardiometabolic risk in children and adolescents: the HAPPY study [PDF]

, 2012
Clustering of cardiometabolic risk factors can occur during childhood and predisposes individuals to cardiometabolic disease. This study calculated clustered cardiometabolic risk in 100 children and adolescents aged 10-14 years (59 girls) and explored ...
A Moran, AS Gami, AS Kelly, AV Rowlands, AV Rowlands, B Gutin, B Gutin, C Boreham, C Bouchard, C Mattocks, C Riddoch, Catherine J. Kerr, D Martinez-Gomez, Daniel P. Bailey, F Abbasi, G Baquet, G Stratton, GQ Shaibi, GS Berenson, HC McGill Jr, HD McCarthy, I Graham, IM Lee, JA Hawley, JR Ruiz, JR Ruiz, JV Freeman, JW Twisk, JW Twisk, K Patrick, L Aires, LM Boddy, Louise A. Savory, Lynne M. Boddy, MK Holten, MS Mitchell, ND Ridgers, P Parikh, P Zimmet, S Brage, SA Anderssen, Sarah J. Denton, SH Golden, SJ Fairclough, SM Camhi, SN Blair, T Shemesh, TJ Cole, TS Hannon, U Ekelund, U Ekelund, W Chen   +51 more
core   +2 more sources

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey[S]

Journal of Lipid Research, 2016
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2.
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto   +21 more
doaj   +1 more source

Relationship between blood pressure values, depressive symptoms and cardiovascular outcomes in patients with cardiometabolic disease [PDF]

, 2016
We studied joint effect of blood pressure-BP and depression on risk of major adverse cardiovascular outcome in patients with existing cardiometabolic disease. A cohort of 35537 patients with coronary heart disease, diabetes or stroke underwent depression
Barry, Sarah J.E., Cavanagh, Jonathan, Der, Geoff, Jani, Bhautesh Dinesh, Mair, Frances S., Sattar, Naveed   +5 more
core   +2 more sources

Cardiometabolic diseases.

Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 2019
Cardiometabolic diseases are prevalent in populations and are among the leading causes of death. Objective: This sub-study of the Health, Well-being and Aging (SABE) study describes the self-reported prevalence of diabetes mellitus (DM), hypertension, and atherosclerotic cardiovascular disease (CVD) for its three waves (2000, 2006, and 2010).
Sandra Roberta Gouvea, Ferreira, Alexandre Dias Porto, Chiavegatto Filho, Maria Lúcia, Lebrão, Yeda Aparecida de Oliveira, Duarte, Ruy, Laurenti   +4 more
openaire   +2 more sources

Lipids Metabolism and Cardiometabolic Diseases

International Journal of Molecular Sciences, 2023
Cardiometabolic diseases (CMD) remains the major cause of morbidity and mortality in Western countries, with a marked increased in the last years [...]
Melania Gaggini, Cristina Vassalle
openaire   +3 more sources

The association between cardiorespiratory fitness and cardiometabolic risk in children is mediated by abdominal adiposity: the HAPPY study [PDF]

, 2014
Background: It is unclear whether cardiorespiratory fitness (CRF) is independently linked to cardiometabolic risk in children. This study investigated a) the association between CRF level and presence of cardiometabolic risk disorders using health ...
Bailey, Daniel Paul, Denton, Sarah J., Kerr, Catherine J., Savory, Louise A.   +3 more
core   +2 more sources

Epigenetic processing in cardiometabolic disease [PDF]

Atherosclerosis, 2019
Albeit a consistent body of evidence supports the notion that genes influence cardiometabolic features and outcomes, the "non-genetic regulation" of this process is gaining increasing attention. Plastic chemical changes of DNA/histone complexes - known as epigenetic changes - critically determine gene activity by rapidly modifying chromatin ...
Costantino, Sarah, Mohammed, Shafeeq A, Ambrosini, Samuele, Paneni, Francesco   +3 more
openaire   +3 more sources