Results 21 to 30 of about 86,843 (267)

Obesity and the risk of cardiometabolic diseases

Nature Reviews Cardiology, 2023
The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders.
Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia   +5 more
openaire   +4 more sources

Hypertension and cardiometabolic disease

Frontiers in Bioscience, 2018
Hypertension has  a central role in cardiometabolic disease and is usually associated with  metabolic disorders, such as insulin resistance, obesity, and dyslipidemia. Hyperinsulinemia may increase cardiovascular (CV) risk through its promotion of hypertension, which is possibly a result of chronic enhancement of sympathetic nervous system activity ...
Ivan, Tasic, Dragan, Lovic
openaire   +2 more sources

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey[S]

Journal of Lipid Research, 2016
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2.
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto   +21 more
doaj   +1 more source

Prognostic value of N-terminal Pro–B-Type natriuretic peptide in patients with intermediate coronary lesions

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe optimal treatment strategy for patients with coronary intermediate lesions, defined as diameter stenosis of 50–70%, remains a great challenge for cardiologists.
Chenxi Song, Chenxi Song, Sheng Yuan, Sheng Yuan, Kongyong Cui, Kongyong Cui, Zhongxing Cai, Zhongxing Cai, Rui Zhang, Rui Zhang, Jining He, Jining He, Zheng Qiao, Zheng Qiao, Xiaohui Bian, Xiaohui Bian, Shaoyu Wu, Shaoyu Wu, Haoyu Wang, Haoyu Wang, Rui Fu, Rui Fu, Chunyue Wang, Chunyue Wang, Qianqian Liu, Qianqian Liu, Dong Yin, Dong Yin, Lei Jia, Lei Jia, Kefei Dou, Kefei Dou   +31 more
doaj   +1 more source

Targeting the vasculature in cardiometabolic disease

Journal of Clinical Investigation, 2022
Obesity has reached epidemic proportions and is a major contributor to insulin resistance (IR) and type 2 diabetes (T2D). Importantly, IR and T2D substantially increase the risk of cardiovascular (CV) disease. Although there are successful approaches to maintain glycemic control, there continue to be increased CV morbidity and mortality associated with
Nabil E. Boutagy, Abhishek K. Singh, William C. Sessa   +2 more
openaire   +3 more sources

Synergistic effect of the commonest residual risk factors, remnant cholesterol, lipoprotein(a), and inflammation, on prognosis of statin-treated patients with chronic coronary syndrome

Journal of Translational Medicine, 2022
Background Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors.
Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou, Jian-Jun Li   +9 more
doaj   +1 more source

Epigenetic processing in cardiometabolic disease [PDF]

Atherosclerosis, 2019
Albeit a consistent body of evidence supports the notion that genes influence cardiometabolic features and outcomes, the "non-genetic regulation" of this process is gaining increasing attention. Plastic chemical changes of DNA/histone complexes - known as epigenetic changes - critically determine gene activity by rapidly modifying chromatin ...
Costantino, Sarah, Mohammed, Shafeeq A, Ambrosini, Samuele, Paneni, Francesco   +3 more
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Uric acid and cardiometabolic diseases [PDF]

Clinical Hypertension, 2020
AbstractHyperuricemia, which has been considered as a cause of gout and nephrolithiasis has recently been suggested to be associated with hypertension, coronary heart disease, heart failure, atrial fibrillation, insulin resistance, and nonalcoholic fatty liver disease.
Seung Jae Lee, Byeong Kil Oh, Ki-Chul Sung   +2 more
openaire   +3 more sources

Cardiometabolic diseases.

Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 2019
Cardiometabolic diseases are prevalent in populations and are among the leading causes of death. Objective: This sub-study of the Health, Well-being and Aging (SABE) study describes the self-reported prevalence of diabetes mellitus (DM), hypertension, and atherosclerotic cardiovascular disease (CVD) for its three waves (2000, 2006, and 2010).
Sandra Roberta Gouvea, Ferreira, Alexandre Dias Porto, Chiavegatto Filho, Maria Lúcia, Lebrão, Yeda Aparecida de Oliveira, Duarte, Ruy, Laurenti   +4 more
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Identification of Key Genes as Early Warning Signals of Acute Myocardial Infarction Based on Weighted Gene Correlation Network Analysis and Dynamic Network Biomarker Algorithm

Frontiers in Immunology, 2022
PurposeThe specific mechanisms and biomarkersunderlying the progression of stable coronary artery disease (CAD) to acute myocardial infarction (AMI) remain unclear.
Chenxi Song, Chenxi Song, Zheng Qiao, Zheng Qiao, Luonan Chen, Jing Ge, Rui Zhang, Rui Zhang, Sheng Yuan, Sheng Yuan, Xiaohui Bian, Xiaohui Bian, Chunyue Wang, Chunyue Wang, Qianqian Liu, Qianqian Liu, Lei Jia, Lei Jia, Rui Fu, Rui Fu, Kefei Dou, Kefei Dou   +21 more
doaj   +1 more source