Results 11 to 20 of about 4,979,977 (315)

Epigenetic processing in cardiometabolic disease [PDF]

Atherosclerosis, 2019
Albeit a consistent body of evidence supports the notion that genes influence cardiometabolic features and outcomes, the "non-genetic regulation" of this process is gaining increasing attention. Plastic chemical changes of DNA/histone complexes - known as epigenetic changes - critically determine gene activity by rapidly modifying chromatin ...
Costantino, Sarah, Mohammed, Shafeeq A, Ambrosini, Samuele, Paneni, Francesco   +3 more
openaire   +5 more sources

Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease [PDF]

, 2021
To understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants, one with ‘adverse’ metabolic effects (UFA) and the other with, paradoxically ...
Yaghootkar, H., Wood, A.R., Cule, M, Thomas, E.L., Martin, S., Liu, Y., Bell, J.D., Sorokin, E., Frayling, T., Whitcher, B., Beaumont, R.N., Basty, N., Tyrrell, J.   +12 more
core   +1 more source

Inflammatory markers and cardiometabolic diseases [PDF]

Acta Clinica Belgica, 2015
A growing body of evidence emerges that obesity, metabolic syndrome, type 2 diabetes and cardiovascular disease are intimately related to chronic inflammation.A narrative review summarizing the most recent data of the literature describing the pathological implications of inflammation in obese patients with cardiometabolic disorders.Besides high ...
ESSER, Nathalie, Paquot, Nicolas, Scheen, André   +2 more
openaire   +2 more sources

Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study

Thrombosis Journal, 2021
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed to examine the relationship between
Jia Peng, Ming-Ming Liu, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Jie Qian, Ke-Fei Dou, Cheng-Gang Zhu, Jian-Jun Li   +9 more
doaj   +1 more source

Correlation of cumulative exposure to metabolic factors with progression of lower extremity arterial disease in type 2 diabetic patients

Di-san junyi daxue xuebao, 2022
Objective To investigate the correlation between cumulative exposure to metabolic factors and progression of lower extremity arterial disease (LEAD) in patients with type 2 diabetes mellitus (T2DM).
YOU Mei, LIU Yushuang, YANG Ping, LI Li, YANG Ruomei   +4 more
doaj   +1 more source

The incretin system and cardiometabolic disease [PDF]

Canadian Journal of Cardiology, 2010
Rates of type 2 diabetes, obesity and their associated detrimental cardiovascular effects are rapidly increasing. Despite the availability of several treatment options for type 2 diabetes and the use of intensive regimens combining several antidiabetic drugs, less than one-half of all patients reach a target glycosylated hemoglobin level of less than 7%
Paul E, Szmitko, Lawrence A, Leiter, Subodh, Verma   +2 more
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GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy

Journal of Lipid Research, 2017
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes.
Santhosh Satapati, Ying Qian, Margaret S. Wu, Aleksandr Petrov, Ge Dai, Sheng-ping Wang, Yonghua Zhu, Xiaolan Shen, Eric S. Muise, Ying Chen, Emanuel Zycband, Adam Weinglass, Jerry Di Salvo, John S. Debenham, Jason M. Cox, Ping Lan, Vinit Shah, Stephen F. Previs, Mark Erion, David E. Kelley, Liangsu Wang, Andrew D. Howard, Jin Shang   +22 more
doaj   +1 more source

Evaluation of Bioelectrical Impedance Analysis for Identifying Overweight Individuals at Increased Cardiometabolic Risk:A Cross-Sectional Study [PDF]

, 2014
OBJECTIVE: To investigate whether bioelectrical impedance analysis could be used to identify overweight individuals at increased cardiometabolic risk, defined as the presence of metabolic syndrome and/or diabetes.DESIGN AND METHODS: Cross-sectional study
Lamb Maxine J. E., Christopher D Byrne, Wilson, J.F., Lamb, M.J.E., Wild, S.H., Lamb, Maxine J E, Byrne, Christopher D, Wild, Sarah H; id_orcid, Wilson James F., Byrne Christopher D., Sarah H Wild, James F Wilson, Wild Sarah H., Wilson, James F; id_orcid, Byrne, Christopher D., Maxine J E Lamb   +15 more
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Glucagon receptor antagonism induces increased cholesterol absorption[S]

Journal of Lipid Research, 2015
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia.
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang   +22 more
doaj   +1 more source

Obesity and the risk of cardiometabolic diseases

Nature Reviews Cardiology, 2023
The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders.
Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia   +5 more
openaire   +4 more sources