Results 91 to 100 of about 123,173 (290)

Association between loneliness and incident atrial fibrillation across different genetic predisposition: findings from the UK Biobank

European Journal of Medical Research
Background Loneliness has garnered significant attention globally, with extensive exploration of its association with cardiovascular disease. However, a notable research gap persists concerning loneliness and its potential link to atrial fibrillation (AF)
Zechen Liu, Yanjun Song, Shanshan Shi, Zhihao Zheng, Weihua Song, Wenjia Zhang, Kefei Dou   +6 more
doaj   +1 more source

Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease

Cardiovascular Diabetology, 2020
Background The present cohort study aims to examine the relationship between fibrinogen (Fib) levels and glucose metabolism [fasting blood glucose (FBG) and hemoglobin A1c (HbA1c)] and investigate the impact of high Fib on cardiovascular outcomes in ...
Shuo-Lin Liu, Na-Qiong Wu, Hui-Wei Shi, Qian Dong, Qiu-ting Dong, Ying Gao, Yuan-Lin Guo, Jian-Jun Li   +7 more
doaj   +1 more source

Common Therapeutic Targets in Cardiometabolic Disease [PDF]

Science Translational Medicine, 2014
Cardiovascular disease and insulin resistance syndrome interactions provide joint therapeutic targets.
Gabrielle, Fredman, Lale, Ozcan, Ira, Tabas   +2 more
openaire   +2 more sources

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity [PDF]

, 2018
Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure.
Costa, Rafael M., Lobato, Núbia S., Neves, Karla B., Tostes, Rita C.   +3 more
core   +3 more sources

Toward New Biomarkers of Cardiometabolic Diseases [PDF]

Cell Metabolism, 2013
Cardiometabolic diseases can be present long before becoming clinically apparent. Accurate predictors of disease are of particular importance since the delay or prevention of morbidity is possible via pharmacological and behavioral interventions. Metabolomics is increasingly applied to biomarker discovery.
Roberts, Lee D., Gerszten, Robert E.
openaire   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Circulating Oxidized mtDNA is Associated Broadly with Cardiovascular Disease in a Longitudinal Cohort Study of Psoriasis

JID Innovations
Psoriasis (PSO) is a chronic and systemic inflammatory autoimmune disease associated with atherosclerosis and myocardial infarction. Given that atherosclerosis is both inflammation and immune driven, we sought to expand on known immune and inflammatory ...
Sundus S. Lateef, Grace A. Ward, Haiou Li, Carla Pantoja, Elizabeth Florida, Christin G. Hong, Justin Rodante, Andrew Keel, Marcus Y. Chen, Alexander V. Sorokin, Martin P. Playford, Nehal N. Mehta   +11 more
doaj   +1 more source

Gene-exercise interactions in the development of cardiometabolic diseases

Journal of Physical Fitness and Sports Medicine, 2016
Cardiometabolic diseases such as type 2 diabetes mellitus, stroke, and coronary heart disease are complex disorders influenced by multiple genetic and environmental factors.
Kumpei Tanisawa, Masashi Tanaka, Mitsuru Higuchi   +2 more
doaj   +1 more source

Cardiometabolic diseases, frailty, and healthcare utilization and expenditure in community-dwelling Chinese older adults

Scientific Reports, 2021
This study investigated associations between cardiometabolic diseases, frailty, and healthcare utilization and expenditure among Chinese older adults. The participants were 5204 community-dwelling adults aged at least 60 years from the China Health and ...
Ke Gao, Bo-Lin Li, Lei Yang, Dan Zhou, Kang-Xi Ding, Ju Yan, Ya-Jie Gao, Xiao-Rui Huang, Xiao-Pu Zheng   +8 more
doaj   +1 more source