Results 161 to 170 of about 310,703 (307)

Haemodynamic‐energetic mechanism of sudden cardiac death in severe aortic stenosis: A modelling study

The Journal of Physiology, EarlyView.
Abstract figure legend A sudden decrease in total peripheral resistance (TPR), as observed during vasovagal syncope, leads to a reduction in aortic systolic pressure (AO pressure) and afterload. In healthy individuals, the consequent decrease in left ventricular systolic pressure (LV pressure) lowers stroke work and myocardial energy expenditure.
Martin Dvoulety, Michal Sitina
wiley   +1 more source

Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy

Journal of Molecular and Cellular Cardiology Plus
Introduction: Hypertrophic cardiomyopathy (HCM) results from pathogenic variants in sarcomeric protein genes that increase myocyte energy demand and lead to cardiac hypertrophy.
Arpana Vaniya, Anja Karlstaedt, Damla Gulkok, Tilo Thottakara, Yamin Liu, Sili Fan, Hannah Eades, Styliani Vakrou, Ryuya Fukunaga, Hilary J. Vernon, Oliver Fiehn, M. Roselle Abraham   +11 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy.

Journal of the American College of Cardiology, 2021
A. Dybro, T. Rasmussen, R. Nielsen, M. Andersen, M. Jensen, S. Poulsen   +5 more
semanticscholar   +1 more source

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

The Journal of Physiology, EarlyView.
Abstract figure legend We present a shape modelling‐based morphological analysis of sex differences in cardiac anatomy. We conduct our analysis on 456 healthy subjects from the UK Biobank (227M/229F) to uncover sex‐based differences in healthy cardiac morphology.
Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck   +4 more
wiley   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Elevational variation in heart mass and suppression of hypoxia‐induced right ventricle hypertrophy in Andean leaf‐eared mice (Phyllotis)

The Journal of Physiology, EarlyView.
Abstract figure legend In lowland mammals that ascend to high elevation, hypoxia‐induced changes in the pulmonary circulation can give rise to hypoxic pulmonary hypertension (HPH) and associated right‐ventricle (RV) hypertrophy. Andean mice with broad elevational ranges have greater heart mass relative to body size at higher elevations, but they ...
Naim M. Bautista, Nathanael D. Herrera, Marcial Quiroga‐Carmona, Chandrasekhar Natarajan, Adriana Rico‐Cernohorska, Jorge Salazar Bravo, Graham R. Scott, Guillermo D'Elía, Zachary A. Cheviron, Jay F. Storz   +9 more
wiley   +1 more source

Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity

Cell Death Discovery
Adriamycin (ADR), as an anti-cancer drug in routine clinical application, is utilized to treat various cancers such as ovarian cancer, hematological malignant tumor, and endometrial carcinoma.
Zheng Wang, Yanli Zhu, Yu Yao, Wenyu Zhang, Bo Wang, Jing Wang, Yang Yang, Liwen Liu   +7 more
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

The Lancet, 2020
I. Olivotto, A. Oreziak, R. Barriales-Villa, T. Abraham, A. Masri, P. García-Pavía, S. Saberi, Neal K. Lakdawala, M. Wheeler, A. Owens, M. Kubanek, W. Wojakowski, Morten K Jensen, J. Gimeno-Blanes, K. Afshar, J. Myers, Sheila M. Hegde, S. Solomon, A. Sehnert, David X. Zhang, Wanying Li, Mondira Bhattacharya, J. Edelberg, C. Waldman, Steven J. Lester, Andrew Wang, Carolyn Y. Ho, D. Jacoby, J. Bartunek, A. Bondue, E. V. Craenenbroeck, D. Zemánek, Morten Jensen, J. Mogensen, J. J. Thune, P. Charron, A. Hagège, O. Lairez, J. Trochu, C. Axthelm, H. Duengen, N. Frey, V. Mitrović, M. Preusch, J. Schulz-Menger, T. Seidler, M. Arad, M. Halabi, A. Katz, D. Monakier, Offir Paz, S. Viskin, D. Zwas, H. Rocca, M. Michels, D. Dudek, Z. Oko-Sarnowska, N. Cardim, H. Pereira, P. G. Pavía, J. G. Blanes, R. H. Urbano, Luis Miguel Rincón Diaz, P. Elliott, Z. Yousef, T. Abraham, P. Alvarez, R. Bach, R. Becker, L. Choudhury, D. Fermin, J. Jefferies, Christopher Kramer, Neal K. Lakdawala, Steven J. Lester, A. Marian, Mathew Maurer, S. Nagueh, David Owens, F. Rader, M. Sherrid, J. Shirani, J. Symanski, A. Turer, O. Wever-Pinzon, M. Wheeler, T. Wong, M. Yamani   +87 more
semanticscholar   +1 more source