Results 71 to 80 of about 3,870 (268)

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

open access: yesChemMedChem, Volume 20, Issue 9, May 5, 2025.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés   +7 more
wiley   +1 more source

The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations Comportamento da troponina I e CK-MB massa em crianças submetidas a correção cirúrgica das cardiopatias congênitas

open access: yesBrazilian Journal of Cardiovascular Surgery, 2003
OBJECTIVE: To analyze the behavior of troponin (TROP I) and CKMB mass (CKMBm) in regards to the addition of magnesium in cardioplegic solutions; and also the influence of per-operative factors.
Pedro Rafael Salerno   +7 more
doaj   +1 more source

Rapid and MR-Independent IK1 activation by aldosterone during ischemia-reperfusion [PDF]

open access: yes, 2015
In ST elevation myocardial infarction (STEMI) context, clinical studies have shown the deleterious effect of high aldosterone levels on ventricular arrhythmia occurrence and cardiac mortality.
Alexandre, J   +8 more
core   +3 more sources

Improvement in short‐term outcome over time, in a single center embarking on a canine mitral valve repair program using a structured multidisciplinary approach

open access: yesVeterinary Surgery, Volume 54, Issue 4, Page 675-685, May 2025.
Abstract Objective To describe a structured approach to the development of a mitral valve repair (MVR) program for dogs with myxomatous mitral valve disease (MMVD) and to document the change in short term outcome over time. Study design Clinical prospective study. Animals Dogs (n = 132) with MMVD undergoing MVR at a single hospital.
Daniel J. Brockman   +8 more
wiley   +1 more source

2,3-Butanedione monoxime attenuates the β-adrenergic response of the L-type Ca2+ current in rat ventricular cardiomyocytes [PDF]

open access: yesJournal of Pharmacy & Pharmacognosy Research, 2016
Context: 2,3-Butanedione monoxime (BDM), an uncoupler of cardiac contraction, is commonly used in enzymatic dissociations to prevent hypercontraction of cardiomyocytes and in cardioplegic solutions to decrease oxygen demand during surgery.
Julio Alvarez-Collazo   +3 more
doaj  

Cardiac taurine and principal amino acids in right and left ventricles of patients with either aortic valve stenosis or coronary artery disease:the importance of diabetes and gender [PDF]

open access: yes, 2014
Free intracellular taurine and principal α-amino acids (glutamate, glutamine, aspartate, asparagine and alanine) are abundant in human heart. They are cellular regulators and their concentration can change in response to disease and cardiac insults and ...
Angelini, Gianni D   +4 more
core   +2 more sources

A Rare Case of Both Cardiac Myxoma and Left Coronary AVF, Diagnosis, and Management

open access: yesClinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT We present the case of a 62‐year‐old woman who was diagnosed with both cardiac myxoma and left coronary AVF, and we go on to discuss the course of her treatment and the outcome. In conclusion, this case study highlights the rare coexistence of an atrial myxoma and a congenital coronary arteriovenous fistula in a 65‐year‐old woman.
Isa Khaheshi   +3 more
wiley   +1 more source

The potential hazard of particulate contamination of cardioplegic solutions

open access: yesThe Journal of Thoracic and Cardiovascular Surgery, 1984
The potential hazard of particulate debris in unfiltered cardioplegic solutions was assessed using the isolated rat heart preparation. Five intravenous solutions were evaluated: These were manufactured by three pharmaceutical firms (two United States and one British) and are commonly used as bases for preparing clinical cardioplegic solutions ...
Lary A. Robinson   +2 more
openaire   +3 more sources

The isolated, perfused working heart preparation of the mouse—Advantages and pitfalls

open access: yesActa Physiologica, Volume 241, Issue 4, April 2025.
Abstract Isolated, perfused hearts are viable for hours outside the body, and important research findings have been made using mouse hearts ex vivo. In the Langendorff perfusion mode, the coronary tree is perfused via retrograde flow of a perfusate down the ascending aorta.
Diana S. Usai   +2 more
wiley   +1 more source

Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery

open access: yesJournal of the Practice of Cardiovascular Sciences
Introduction: Cardioplegia is crucial for myocardial protection during cardiac surgery. However, the impact of different cardioplegia formulations on patients’ metabolomic responses has not been explored.
Chananya Karunasumetta   +3 more
doaj   +1 more source

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