Results 71 to 80 of about 3,870 (268)
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés+7 more
wiley +1 more source
OBJECTIVE: To analyze the behavior of troponin (TROP I) and CKMB mass (CKMBm) in regards to the addition of magnesium in cardioplegic solutions; and also the influence of per-operative factors.
Pedro Rafael Salerno+7 more
doaj +1 more source
Rapid and MR-Independent IK1 activation by aldosterone during ischemia-reperfusion [PDF]
In ST elevation myocardial infarction (STEMI) context, clinical studies have shown the deleterious effect of high aldosterone levels on ventricular arrhythmia occurrence and cardiac mortality.
Alexandre, J+8 more
core +3 more sources
Abstract Objective To describe a structured approach to the development of a mitral valve repair (MVR) program for dogs with myxomatous mitral valve disease (MMVD) and to document the change in short term outcome over time. Study design Clinical prospective study. Animals Dogs (n = 132) with MMVD undergoing MVR at a single hospital.
Daniel J. Brockman+8 more
wiley +1 more source
2,3-Butanedione monoxime attenuates the β-adrenergic response of the L-type Ca2+ current in rat ventricular cardiomyocytes [PDF]
Context: 2,3-Butanedione monoxime (BDM), an uncoupler of cardiac contraction, is commonly used in enzymatic dissociations to prevent hypercontraction of cardiomyocytes and in cardioplegic solutions to decrease oxygen demand during surgery.
Julio Alvarez-Collazo+3 more
doaj
Cardiac taurine and principal amino acids in right and left ventricles of patients with either aortic valve stenosis or coronary artery disease:the importance of diabetes and gender [PDF]
Free intracellular taurine and principal α-amino acids (glutamate, glutamine, aspartate, asparagine and alanine) are abundant in human heart. They are cellular regulators and their concentration can change in response to disease and cardiac insults and ...
Angelini, Gianni D+4 more
core +2 more sources
A Rare Case of Both Cardiac Myxoma and Left Coronary AVF, Diagnosis, and Management
ABSTRACT We present the case of a 62‐year‐old woman who was diagnosed with both cardiac myxoma and left coronary AVF, and we go on to discuss the course of her treatment and the outcome. In conclusion, this case study highlights the rare coexistence of an atrial myxoma and a congenital coronary arteriovenous fistula in a 65‐year‐old woman.
Isa Khaheshi+3 more
wiley +1 more source
The potential hazard of particulate contamination of cardioplegic solutions
The potential hazard of particulate debris in unfiltered cardioplegic solutions was assessed using the isolated rat heart preparation. Five intravenous solutions were evaluated: These were manufactured by three pharmaceutical firms (two United States and one British) and are commonly used as bases for preparing clinical cardioplegic solutions ...
Lary A. Robinson+2 more
openaire +3 more sources
The isolated, perfused working heart preparation of the mouse—Advantages and pitfalls
Abstract Isolated, perfused hearts are viable for hours outside the body, and important research findings have been made using mouse hearts ex vivo. In the Langendorff perfusion mode, the coronary tree is perfused via retrograde flow of a perfusate down the ascending aorta.
Diana S. Usai+2 more
wiley +1 more source
Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery
Introduction: Cardioplegia is crucial for myocardial protection during cardiac surgery. However, the impact of different cardioplegia formulations on patients’ metabolomic responses has not been explored.
Chananya Karunasumetta+3 more
doaj +1 more source