Results 11 to 20 of about 290 (164)
Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets [PDF]
Фармакокинетика и ФармакодинамикаEight important biotargets of biaromatic cardioprotective drugs were selected in this work: calcium Cav1.2-channel, sodium Nav1.5-channel, potassium hERG-channel and Kv1.5-channel, HCN-channel, β1-adrenergic receptor, ryanodine RyR2-receptor and σ1 ...
G. V. Mokrov +5 more
doaj +3 more sources
Assessment of myocardial extracellular volume on body computed tomography in breast cancer patients treated with anthracyclines. [PDF]
Quant Imaging Med Surg, 2020 Background: Cancer treatment with anthracyclines may lead to an increased incidence of cardiac disease due to cardiotoxicity, as they may cause irreversible myocardial fibrosis.
Monti CB +7 more
europepmc +3 more sources
Ischemia/Reperfusion Injury: Pathophysiology, Current Clinical Management, and Potential Preventive Approaches. [PDF]
Mediators Inflamm, 2020 Myocardial ischemia reperfusion syndrome is a complex entity where many inflammatory mediators play different roles, both to enhance myocardial infarction‐derived damage and to heal injury. In such a setting, the establishment of an effective therapy to treat this condition has been elusive, perhaps because the experimental treatments have been ...
Sánchez-Hernández CD +3 more
europepmc +2 more sources
4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action. [PDF]
Oxid Med Cell Longev, 2020 A set of six new 4‐pyridinio‐1,4‐dihydropyridine (1,4‐DHP) compounds has been synthesized. The calcium channel modulating activity of these compounds was evaluated in an aorta vascular smooth muscle cell line (A7R5), in an isolated rat aortic ring model, and in human neuroblastoma cell lines (SH‐SY5Y).
Domracheva I +7 more
europepmc +2 more sources
Thioredoxin-1: a cardioprotector against stress [PDF]
Cardiovascular Research, 2020 This editorial refers to ‘Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart’ by S.I. Oka et al., pp. 1742–1755.
Perone F., Lembo G.
openaire +3 more sources
Фармакокинетика и Фармакодинамика, 2023 The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents.
G. V. Mokrov
doaj +1 more source
Food Science &Nutrition, Volume 11, Issue 6, Page 2547-2579, June 2023., 2023 Therapeutics properties of animal milk components against pathogenic viruses such as COVID‐19. Abstract The global pandemic of COVID‐19 is considered one of the most catastrophic events on earth. During the pandemic, food ingredients may play crucial roles in preventing infectious diseases and sustaining people's general health and well‐being.
Parminder Singh +2 more
wiley +1 more source
PROTEOMICS, Volume 23, Issue 3-4, February 2023., 2023 Abstract Post‐translational modifications (PTMs) dynamically regulate proteins and biological pathways, typically through the combined effects of multiple PTMs. Lysine residues are targeted for various PTMs, including malonylation and succinylation. However, PTMs offer specific challenges to mass spectrometry‐based proteomics during data acquisition ...
Joanna Bons +6 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 The antioxidant can inhibit oxidative stress and apoptosis, which has a role in an important mechanism on diabetic‐induced cardiac cell damage. The research goal was to prove the antioxidative stress and antiapoptosis effect of chitosan nanoparticles as a cardioprotector in streptozotocin‐induced diabetic rats.
Giftania Wardani +5 more
wiley +1 more source
Journal of Oncology, Volume 2022, Issue 1, 2022., 2022 Objective. This study aimed to review the potential chemoprotective effects of curcumin against the doxorubicin‐induced cardiotoxicity. Methods. According to the PRISMA guideline, a comprehensive systematic search was performed in different electronic databases (Web of Science, PubMed, and Scopus) up to July 2021.
Qian Zhang +2 more
wiley +1 more source