Results 11 to 20 of about 106,945 (256)

Pyk2 regulates sepsis-induced lung injury via ferroptosis [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): The onset of sepsis represents a hyper-inflammatory condition that can lead to organ failure and mortality. Recent findings suggest a potential beneficial effect of protein tyrosine kinase Pyk2 inhibitor on sepsis in a mouse model.
Jia Wang, Pengtao Bao, Yugeng Liu
doaj   +1 more source

Effect of Fluid Resuscitation Strategies for Obese Patients with Sepsis and Septic Shock: A Systematic Review

Intensive Care Research, 2022
Purpose As the Surviving Sepsis Campaign (2021) recommended, patients with sepsis should be given a liquid infusion of 30 ml/kg (ideal body weight). However, the strategy may result in insufficient resuscitation for obese patients with sepsis. Therefore,
Yijun Zhang, Minjie Wang, Zongqing Lu, Min Yang   +3 more
doaj   +1 more source

MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling

Redox Biology, 2023
Oxidative stress is considered a key factor contributing to the initiation and development of cardiac injury following ischaemia‒reperfusion (I/R). Arachidonate 5-lipoxygenase (ALOX5) is a rate-limiting enzyme for leukotriene biosynthesis.
Kai-Na Shi, Pang-Bo Li, Hui-Xiang Su, Jing Gao, Hui-Hua Li   +4 more
doaj   +1 more source

Time Series Transcriptomic Analysis by RNA Sequencing Reveals a Key Role of PI3K in Sepsis-Induced Myocardial Injury in Mice

Frontiers in Physiology, 2022
Septic cardiomyopathy is the main complication and cause of death of severe sepsis with limited therapeutic strategy. However, the molecular mechanism of sepsis-induced cardiac injury remains unclear.
Xiao Yan, Xiao Yan, Yun-Long Zhang, Xiao Han, Pang-Bo Li, Shu-Bin Guo, Hui-Hua Li   +6 more
doaj   +1 more source

Cardiopulmonary resuscitation

Medicine, 2022
Performing cardiopulmonary resuscitation is a key competency for healthcare professionals. Training in immediate and advanced life support is a requirement for UK doctors; this is depicted in the Foundation training programme competencies and in the Internal Medicine Training curriculum.
Mitropoulou, Panagiota, Fitzsimmons, Samantha   +1 more
openaire   +2 more sources

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy

Frontiers in Pharmacology, 2021
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-induced circulatory and cardiac dysfunction is associated with high mortality rates.
Wenqing Ji, Wenqing Ji, Tiantian Wan, Tiantian Wan, Fang Zhang, Fang Zhang, Xiaomei Zhu, Xiaomei Zhu, Shubin Guo, Shubin Guo, Xue Mei, Xue Mei   +11 more
doaj   +1 more source

Sodium–Glucose Co-Transporter 2 Inhibition With Empagliflozin Improves Cardiac Function After Cardiac Arrest in Rats by Enhancing Mitochondrial Energy Metabolism

Frontiers in Pharmacology, 2021
Empagliflozin is a newly developed antidiabetic drug to reduce hyperglycaemia by highly selective inhibition of sodium–glucose co-transporter 2. Hyperglycaemia is commonly seen in patients after cardiac arrest (CA) and is associated with worse outcomes ...
Yunke Tan, Yunke Tan, Kai Yu, Kai Yu, Lian Liang, Lian Liang, Yuanshan Liu, Yuanshan Liu, Fengqing Song, Fengqing Song, Qiulin Ge, Qiulin Ge, Xiangshao Fang, Xiangshao Fang, Tao Yu, Tao Yu, Zitong Huang, Zitong Huang, Longyuan Jiang, Longyuan Jiang, Peng Wang, Peng Wang   +21 more
doaj   +1 more source

Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest

Intensive Care Medicine Experimental, 2023
Background Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some patients may eventually progress ...
Tianfeng Hua, Yuqian Chu, Minjie Wang, Yijun Zhang, Wei Shi, Qihui Huang, Liangliang Zhang, Min Yang   +7 more
doaj   +1 more source

Early human albumin administration is associated with reduced mortality in septic shock patients with acute respiratory distress syndrome: A retrospective study from the MIMIC-III database

Frontiers in Physiology, 2023
Background: Sepsis-induced acute respiratory distress syndrome (ARDS) was associated with higher mortality. It is unclear whether albumin supplementation early in the course of ARDS can affect the prognostic outcomes of septic shock (SS) patients with ...
Xiya Wang, Xiya Wang, Tianqian Zhang, Tianqian Zhang, Xinzhen Gao, Hongbo Cai, Mengke Guo, Mengke Guo, Qi Liu, Qi Liu, Shubin Guo, Shubin Guo, Wenqing Ji, Wenqing Ji   +13 more
doaj   +1 more source

Variability of extracorporeal cardiopulmonary resuscitation utilization for refractory adult out-of-hospital cardiac arrest: an international survey study. [PDF]

, 2018
Objective: A growing interest in extracorporeal cardiopulmonary resuscitation (ECPR) as a rescue strategy for refractory adult out-of-hospital cardiac arrest (OHCA) currently exists.
Benjamin S. Abella, Byung Kook Lee, Chun Song Youn, Clifton W. Callaway, David F. Gaieski, Jon C. Rittenberger, Jonathan Elmer, Joo Suk Oh, Joshua C. Reynolds, Kelly N. Sawyer, Korean Hypothermia Network Investigators and the National Post-Arrest Research Consortium, Michael Kurz, Minjung Kathy Chae, Patrick J. Coppler, Seung Pill Choi, Won Young Kim, Young-Min Kim   +16 more
core   +2 more sources