Results 31 to 40 of about 180,776 (249)

Systematic review of interventions to improve appropriate use and outcomes associated with do-not-attempt-cardiopulmonary-resuscitation decisions [PDF]

, 2014
The treatment for a cardiac arrest, cardiopulmonary resuscitation (CPR), may be lifesaving following an acute, potentially reversible illness. Yet this treatment is unlikely to be effective if cardiac arrest occurs as part of the dying process towards ...
Field, Richard A., Perkins, Gavin D., Field, Richard A, Perkins, Gavin D, Fritz, Zoë, Grove, Amy, Baker, Annalie, Grove, Amy L.   +7 more
core   +1 more source

Predicting sepsis in-hospital mortality with machine learning: a multi-center study using clinical and inflammatory biomarkers

European Journal of Medical Research
Background This study aimed to develop and validate an interpretable machine-learning model that utilizes clinical features and inflammatory biomarkers to predict the risk of in-hospital mortality in critically ill patients suffering from sepsis. Methods
Guyu Zhang, Fei Shao, Wei Yuan, Junyuan Wu, Xuan Qi, Jie Gao, Rui Shao, Ziren Tang, Tao Wang   +8 more
doaj   +1 more source

Gut microbial immunometabolic pathways associated with cardiac arrest risk: genetic evidence and exploratory fecal microbiome profiling

Frontiers in Cell and Developmental Biology
BackgroundCardiac arrest remains difficult to predict, and upstream biological determinants are poorly defined. Gut microbiota can influence host metabolism, immunity and inflammation, but their relevance to cardiac arrest risk remains unclear.MethodsWe ...
Liuyang Xie, Liuyang Xie, Liuyang Xie, Yuepeng Hu, Yuepeng Hu, Yuepeng Hu, Keke Du, Keke Du, Keke Du, Kecheng Liu, Kecheng Liu, Kecheng Liu, Shibo Yang, Shibo Yang, Shibo Yang, Yan Zhou, Yan Zhou, Yan Zhou, Qiang Zhang, Qiang Zhang, Qiang Zhang, Chao Lan, Chao Lan, Chao Lan   +23 more
doaj   +1 more source

Machine learning-based prediction model of acute kidney injury in patients with acute respiratory distress syndrome

BMC Pulmonary Medicine, 2023
Background Acute kidney injury (AKI) can make cases of acute respiratory distress syndrome (ARDS) more complex, and the combination of the two can significantly worsen the prognosis.
Shuxing Wei, Yongsheng Zhang, Hongmeng Dong, Ying Chen, Xiya Wang, Xiaomei Zhu, Guang Zhang, Shubin Guo   +7 more
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Global, regional, and national cardiovascular disease burden attributable to smoking from 1990 to 2021: Findings from the GBD 2021 Study

Tobacco Induced Diseases
Introduction Smoking poses a serious threat to cardiovascular health. The aim of the study is to evaluate the global, regional, and national burden of smokingattributable cardiovascular disease (CVD) and set priorities for future tobacco control ...
Shuaijie Zhu, Jian Gao, Liangliang Zhang, Wanguo Dong, Wei Shi, Heng Guo, Xiaoyu Zhang, Tianfeng Hua, Min Yang   +8 more
doaj   +1 more source

Silence around SUDEP and its impact on caregivers of individuals with developmental and epileptic encephalopathies: An international survey

Epilepsia Open, EarlyView.
Abstract Objective Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of epilepsy‐related mortality, particularly in individuals with Developmental and Epileptic Encephalopathies (DEEs). The goal of this work is to assess SUDEP‐related knowledge, information practices, emotional and psychological impact, and the use of preventive measures
José Ángel Aibar, Ana Cantó Martínez, David Alarcón Alarcón, Eulalia Turón‐Viñas, Rima Nabbout, Isabella Brambilla, Franck Kalume, Danielle Andrade, Simona Giorgi   +8 more
wiley   +1 more source

Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase

Frontiers in Pharmacology, 2020
Hypertension is a major cause of heart attack and stroke. Our recent study revealed that gallic acid (GA) exerts protective effects on pressure overload-induced cardiac hypertrophy and dysfunction.
Xiao Yan, Qi-Yu Zhang, Yun-Long Zhang, Xiao Han, Shu-Bin Guo, Hui-Hua Li, Hui-Hua Li   +6 more
doaj   +1 more source

Sudden unexpected death in epilepsy: An Italian expert consensus statement on risk, mechanisms, prevention, and therapeutic strategies

Epilepsia Open, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature mortality in people with epilepsy, particularly in those with tonic–clonic seizures (TCSs), developmental and epileptic encephalopathies (DEEs), and drug‐resistant epilepsy.
Vincenzo Belcastro, Fedele Dono, Giovanni Falcicchio, Lorenzo Gigli, Angela La Neve, Sara Matricardi, Barbara Mostacci, Angelo Pascarella, Leandro Pecchia, Emilio Russo, Pasquale Striano   +10 more
wiley   +1 more source

U-shaped correlation of lymphocyte count with all-cause hospital mortality in sepsis and septic shock patients: a MIMIC-IV and eICU-CRD database study

International Journal of Emergency Medicine
Background In sepsis, the relationship between lymphocyte counts and patient outcomes is complex. Lymphocytopenia and lymphocytosis significantly influence survival, illustrating the dual functionality of lymphocytes in responding to infections.
Guyu Zhang, Tao Wang, Le An, ChenChen Hang, XingSheng Wang, Fei Shao, Rui Shao, Ziren Tang   +7 more
doaj   +1 more source