Results 51 to 60 of about 180,776 (249)

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation

Cell Death and Disease
The mitochondrial dynamic imbalance is an important cause of myocardial ischaemia/reperfusion (I/R) injury and dysfunction. Psmb8, as one of the immunoproteasome catalytic subunits, is a key regulator of protein homoeostasis, inflammation and some ...
Hui-Xiang Su, Luo-Luo Xu, Pang-Bo Li, Hai-Lian Bi, Wen-Xi Jiang, Hui-Hua Li   +5 more
doaj   +1 more source

Accidental plant poisonings in France: Lessons from a decade of national toxicovigilance

PLANTS, PEOPLE, PLANET, EarlyView.
Accidental plant poisonings reveal how modern societies are losing everyday botanical knowledge once central to food and health safety. By analyzing a decade of French toxicovigilance data, this study shows that most severe cases arise from plant misidentification or misguided self‐medication.
Gaël Le Roux, Adrien Maillot, Sylvie Michel, Jérôme Langrand, Sébastien Larréché, Christine Tournoud, David Boels, Magali Labadie, Nicolas Delcourt, Nathalie Paret, Luc de Haro, Sandra Sinno‐Tellier   +11 more
wiley   +1 more source

Where to Begin? Prioritizing Procedures for Surgical Skills Training Development: SELF Series Article 2

World Journal of Surgery, EarlyView.
Scaling the global surgical care workforce through independent procedural skills training is essential to address unmet surgical need. Prioritization of a sub‐set of surgical skills is required. During the 2023 Surgical Education Learners Forum (SELF) Symposium, participants developed criteria to prioritize the development of self‐directed and ...
Amelia Levi, David R. Jeffcoach, Nobhojit Roy, Juan Carlos Puyana, Eric O'Flynn, Abebe Bekele   +5 more
wiley   +1 more source

Lifting the Fog on Resuscitation: A Scoping Review to Define Cardiopulmonary Resuscitation

Aims: To summarise current research that defines cardiopulmonary resuscitation and to provide a succinct conceptual defini-tion of cardiopulmonary resuscitation. Design: Scoping review using JBI guidelines to develop the study protocol.
Yen, Margaret, Flynn, Julie, Barr, Jennieffer, Jurd, Catherine   +3 more
core   +1 more source

Fatal pediatric neck entrapment in a lift‐up storage bed: A preventable domestic asphyxial death

Journal of Forensic Sciences, EarlyView.
Abstract Bed‐related deaths are rare in forensic practice and are usually associated with falls, restraint‐related entrapment, or unsafe infant sleeping environments. Fatal mechanical asphyxia involving lift‐up storage beds is an exceptional occurrence, and the few published cases involve adult victims.
Francesco Baldari, Alice Buzzelli, Vittoria Greco, Andrea Guidetti, Valentina Bugelli   +4 more
wiley   +1 more source

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

Association between statins use and mortality in critically ill patients with sepsis included myocardial injury: a retrospective cohort study

European Journal of Medical Research
Background The treatment of patients with sepsis included myocardial injury (SIMI) remains a subject of debate. Given the pharmacological effects of statins in both sepsis and cardiovascular disease, this study aimed to investigate the association ...
Shuxing Wei, Yiming Dong, Yanqian Su, Ying Chen, Xiya Wang, Hongmeng Dong, Danlei Weng, Yue Hu, Shubin Guo, Xue Mei, Wenqing Ji   +10 more
doaj   +1 more source

Metabolomic biomarker differences of sarcopenia in older patients with sepsis

Frontiers in Medicine
BackgroundSarcopenia has a high incidence in older patients with sepsis and is closely associated with poor prognosis, but its metabolic characteristics under this specific stress state remain unclear.
Yiyang Liu, Yiyang Liu, Tianren He, Tianren He, Siyu Chen, Siyu Chen, Ziyi Li, Ziyi Li, Xue Mei, Xue Mei, Xinhua He, Xinhua He, Na Shang, Na Shang   +13 more
doaj   +1 more source

The impact of cardiopulmonary resuscitation (CPR) training on schoolchildren and their CPR knowledge, attitudes toward CPR, and willingness to help others and to perform CPR: mixed methods research design

BMC Public Health, 2020
Background The benefits of cardiopulmonary resuscitation training for schoolchildren are well known, but the appropriate age for introducing training is still being discussed.
Sanela Pivač, Primož Gradišek, Brigita Skela-Savič   +2 more
doaj   +1 more source