Results 81 to 90 of about 15,796 (188)

Comparative effectiveness of combination therapy with SGLT‐2 inhibitors and GLP‐1 RAs compared with SGLT‐2 inhibitors in individuals with type 2 diabetes: A prevalent new‐user cohort study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3273-3284, April 2026.
Abstract Aims To evaluate the effectiveness of combination therapy with sodium‐glucose cotransporter 2 (SGLT‐2) inhibitors and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) compared with continued SGLT‐2 inhibitor therapy in routine practice among individuals with type 2 diabetes.
Gregor A. Maier   +3 more
wiley   +1 more source

Cardiorenal Syndrome in Acute Heart Failure Syndromes

open access: yesInternational Journal of Nephrology, 2011
Impaired cardiac function leads to activation of the neurohumoral axis, sodium and water retention, congestion and ultimately impaired kidney function. This sequence of events has been termed the Cardiorenal Syndrome.
Mohammad Sarraf, Robert W. Schrier
doaj   +1 more source

Cardiorenal Syndrome Type 4—Cardiovascular Disease in Patients with Chronic Kidney Disease: Epidemiology, Pathogenesis, and Management [PDF]

open access: yes, 2011
The term cardiorenal syndrome refers to the interaction between the heart and the kidney in disease and encompasses five distinct types according to the initial site affected and the acute or chronic nature of the injury.
Panagiotis Pateinakis   +1 more
core   +1 more source

Real‐world persistence and dose titration of GLP‐1 receptor agonists in type 2 diabetes: A UK population‐based cohort study by obesity and cardiovascular disease status

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3386-3395, April 2026.
Abstract Aims Real‐world medication use varies across clinical trial and healthcare settings; therefore, we evaluated GLP‐1 receptor agonist (GLP‐1RA) persistence and dose titration among adults with type 2 diabetes in UK primary care, stratified by agent, obesity status, cardiovascular disease (CVD) history, and sex assigned at birth.
Franziska S. Ulrich   +3 more
wiley   +1 more source

A simple prognostic index in acute heart failure [PDF]

open access: yes, 2018
Background Rapid effective triage is integral to emergency care in patients hospitalized for heart failure, to guide the type and intensity of therapy.
Cristina MOLLICA   +3 more
core   +1 more source

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension

open access: yesHemaSphere, Volume 10, Issue 3, March 2026.
Abstract Pulmonary hypertension (PH) is a severe vascular complication of sickle cell disease (SCD); yet, not all patients with SCD develop PH, and PH also arises independently. This duality underscores the need to understand their intersecting biology.
Francesca I. Cendali   +22 more
wiley   +1 more source

Improving Prognosis Estimation in Patients with Heart Failure and the Cardiorenal Syndrome

open access: yesInternational Journal of Nephrology, 2011
The coexistence of heart failure and renal dysfunction constitutes the “cardiorenal syndrome” which is increasingly recognized as a marker of poor prognosis.
Husam M. Abdel-Qadir   +2 more
doaj   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

Síndrome cardiorrenal na insuficiência cardíaca aguda: um círculo vicioso?

open access: yesRevista Portuguesa de Cardiologia, 2014
Resumo: Introdução e objetivos: O valor prognóstico da deterioração da função renal é indiscutível nos doentes com insuficiência cardíaca aguda. No contexto nacional sabe‐se pouco acerca do peso relativo da síndrome cardiorrenal no internamento destes ...
Francisca Caetano   +6 more
doaj   +1 more source

Racial/ethnic disparities in stages of cardiovascular‐kidney‐metabolic syndrome among reproductive‐aged women in the United States: NHANES 2011–2020

open access: yesPregnancy, Volume 2, Issue 2, March 2026.
Abstract Objective Recently, the American Heart Association defined, staged, and highlighted the multisystem consequences of poor cardiovascular‐kidney‐metabolic (CKM) syndrome health with a clarion call to harmonize guidelines and provide opportunities for actionable preventive interventions before overt CVD.
Eric K. Broni   +5 more
wiley   +1 more source

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