Results 71 to 80 of about 86,211 (132)

Bufalin‐Induced Epithelial‐to‐Mesenchymal Transition in Kidney Epithelial Cells

Cell Biology International, Volume 49, Issue 12, Page 1764-1786, December 2025.
ABSTRACT The kidney plays a central role in fluid, electrolyte, and blood pressure regulation, processes tightly coupled to Na⁺/K⁺‐ATPase activity. Beyond its canonical transport function, Na⁺/K⁺‐ATPase also acts as a signaling receptor for cardiotonic steroids (CTSs) such as bufalin, which have been implicated in fibrosis and epithelial‐to‐mesenchymal
Gabriela Morais de Oliveira Barros, Kayo M. Bagri, Claudia Mermelstein, Luis Eduardo M. Quintas   +3 more
wiley   +1 more source

Cardiotonic Activity of Some Adrenal Steroids

, 1956
The inotropic activity of Compounds A acetate, B, E, F, S and DCA was determined upon hypodynamic papillary muscles (cat) (bathed in Krebs-Hensleit solution, ph 7–7.2, with the calcium content reduced to 1.0 mEq./l., and driven by a square wave ...
Jane Frances Emele, Desmond D. Bonnycastle   +1 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms

Biology, 2020
Melanoma is the most common cancer in young adults, with a constantly increasing incidence. Metastatic melanoma is a very aggressive cancer with a 5-year survival rate of about 22−25%.
Laura Soumoy, Mathilde Wells, Ahmad Najem, Mohammad Krayem, Ghanem Ghanem, Stéphanie Hambye, Sven Saussez, Bertrand Blankert, Fabrice Journe   +8 more
doaj   +1 more source

Endogenous cardiotonic steroids in chronic renal failure

, 2011
Background. Previous reports demonstrated that digitalis-like cardiotonic steroids (CTS) contribute to the pathogen-esis of end-stage renal disease. The goal of the present study was to define the nature of CTS in patients with chronic kidney disease ...
David J. Kennedy, Budny, George V., Frolova, Elena V., Elena V. Frolova, Olga V. Fedorova, J. I. Shapiro, S. T. Haller, E. V. Kolmakova, Kolmakova, Elena V., Elena V. Kolmakova, D. Malhotra, A. N. Isachkina, G. Piecha, O. V. Fedorova, George V. Budny, Elena R. Nikitina, E. V. Frolova, Nikitina, Elena R., Piecha, Grzegorz, Deepak Malhotra, Grzegorz Piecha, Haller, Steven T., Isachkina, Alina N., G. V. Budny, E. R. Nikitina, Shapiro, Joseph I., MD, Bagrov, Alexei Y., D. J. Kennedy, Joseph I. Shapiro, Malhotra, Deepak, Alexei Y. Bagrov, Steven T. Haller, A. Y. Bagrov, Kennedy, David J., Alina N. Isachkina   +34 more
core   +1 more source

Effects of cardiotonic steroids on dermal collagen synthesis and wound healing

, 2008
We previously reported that cardiotonic steroids stimulate collagen synthesis by cardiac fibroblasts in a process that involves signaling through the Na-K-ATPase pathway (Elkareh et al. Hypertension 49: 215–224, 2007).
Gupta, Shalini, Jihad Elkareh, Chin, Khew Voon, Shapiro, Joseph I., M.D., Larisa Fedorova, Raju, Vanamala, Fedorova, Larisa, Sankaridrug Periyasamy, El-Okdi, Nasser, Nasser El-Okdi, M. Bashar Kahaleh, Elkareh, Jihad, Shidyak, Amjad, Amjad Shidyak, Kahaleh, M. Bashar, Sleiman Smaili, Vanamala Raju, Xie, Jingwei, Anna P. Shapiro, Smaili, Sleiman, Deepak Malhotra, Shapiro, Anna P., Malhotra, Deepak, Khew Voon Chin, Joseph I. Shapiro, Periyasamy, Sankaridrug, Shalini Gupta, Zijian Xie   +27 more
core   +1 more source

Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised
Marco T. C. Pessôa, Silmara L. G. Alves, Alex G. Taranto, José A. F. P. Villar, Gustavo Blanco, Leandro A. Barbosa   +5 more
doaj   +1 more source

Protein Interaction and Na/K-ATPase-Mediated Signal Transduction

Molecules, 2017
The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane.
Xiaoyu Cui, Zijian Xie
doaj   +1 more source

Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling

International Journal of Nephrology, 2012
The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS)-mediated Na/K-ATPase signaling has been shown to regulate fibrosis ...
Jiang Liu, David J. Kennedy, Yanling Yan, Joseph I. Shapiro   +3 more
doaj   +1 more source

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

Molecules, 2016
Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have
Yang Li, Jin Li, Kun Zhou, Jun He, Jun Cao, Mingrui An, Yan-Xu Chang   +6 more
doaj   +1 more source