Results 61 to 70 of about 86,211 (132)

Cardiotonic steroids on the road to anti-cancer therapy.

, 2007
The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in the ...
Mijatovic, Tatjana, Van Quaquebeke, Eric, Delest, Bruno, Debeir, Olivier, Kiss, Robert, Darro, Francis   +5 more
core   +1 more source

Specialized functional diversity and interactions of the Na,K-ATPase

Frontiers in Physiology, 2016
Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct ...
Igor I. Krivoi, Vladimir V. Matchkov
doaj   +1 more source

Exploring the Cancer Therapeutic Potential of Traditional Medicinal Plants by Modulating the Apoptotic Pathway

BioMed Research International, Volume 2026, Issue 1, 2026.
Introduction Cancer is a versatile disease with a high rate of relapse and mortality. Despite the presence of various treatment modalities, there is a serious need for the development of its management. Phytochemicals, which are abundant in nature, can be turned into novel medications for these types of diseases by optimizing their functions and ...
Mithila Kulkarni, Mohammad Amjad Hussain, Reginald Samson Valdar, Shreya Hebbar, Suparna Laha, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease

Molecules, 2016
Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein.
Krithika Srikanthan, Joseph I. Shapiro, Komal Sodhi   +2 more
doaj   +1 more source

Medicinal Plants Used by Tanzanians for Human Paediatric Ailments: A PRISMA‐Guided Systematic Review of Ethnomedicinal Evidence

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Paediatric ailments (PAs) pose an increasing health and economic challenge in many low‐ and middle‐income countries. In Tanzania, over 80% of the rural population relies on traditional medicine for primary healthcare. Although documentation of medicinal plants (MPs) used to treat and manage PAs remains fragmented, this systematic review consolidates ...
David Sylvester Kacholi, Neema Gideon Mogha, José Agustín Tapia Hernández   +2 more
wiley   +1 more source

Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

Molecules, 2017
Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express
Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Camila Ignácio da Silva, Hugo Caire Castro-Faria-Neto, Patrícia Burth   +4 more
doaj   +1 more source

Nicotiana tabacum: From a Beneficial Plant to Harmful Products—A Comprehensive Review of Smokeless Tobacco and Its Adverse Health Effects

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Nicotiana tabacum is a cash crop that originated in America and was introduced to the world by Christopher Colombus. It is now cultivated in many countries with major producers including China, the USA, India, and Brazil. The plant was widely used by the indigenous people of America for different reasons (spiritual, hallucination, and medical).
Abir Chami, Afaf Allaoui, Hassane Mekhfi, Younes Zaid, José Agustín Tapia Hernández   +4 more
wiley   +1 more source

Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+‐ATPase‐α‐1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Recent studies have highlighted a critical role for a group of natriuretic hormones, cardiotonic steroid (CTS), in mediating renal inflammation and fibrosis associated with volume expanded settings, such as chronic kidney disease.
Fatimah K. Khalaf, Iman Tassavvor, Amal Mohamed, Yiliang Chen, Deepak Malhotra, Zijian Xie, Jiang Tian, Steven T. Haller, Kristen Westfall, W. H. Wilson Tang, David J. Kennedy   +10 more
doaj   +1 more source

Ethnobotanical Survey of Medicinal Plants Utilized by Traditional Healers in Managing Respiratory Tract Infections in the Kagera Region, Tanzania

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Respiratory tract infections (RTIs) are the primary cause of morbidity and mortality in many low‐and middle‐income countries. In most of these countries, including Tanzania, medicinal plants (MPs) are primarily used to manage various ailments, though the majority are not yet documented.
Neema Gideon Mogha, Pamela Epaphra Sola, Elbert Anyambilile Mbukwa, Olivia John Kalokora, Sultan Zahiruddin   +4 more
wiley   +1 more source

CARDIOTONIC STEROIDS AS MODULATORS OF NEURONAL SURVIVAL SIGNALING PATHWAYS: A REVIEW OF CURRENT RESEARCH

Brain cell metabolism is characterized by numerous cellular and molecular mechanisms. Exposure of brain cells to damaging factors leads to mitochondrial dysfunction, the accumulation of ...
E. A. Teplyashina, L. B. Shadrina
core   +1 more source