Results 91 to 100 of about 97,116 (340)

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis [PDF]

, 2005
Previous studies showed that mitoxantrone can reduce disability progression in patients with multiple sclerosis (MS). There is, however, concern that it may cause irreversible cardiomyopathy with reduced left ventricular (LV) ejection fraction (EF) and ...
Ariane Groβ, Athanasiou T, Avasarala JR, De Castro S, Dukart G, Edan G, Edan G, Foster BJ, Ghalie RG, Goffette S, Gonsette RE, Gonsette RE, Goodin DS, Hartung HP, Herman EH, Kappos L, Klaus Jahn, Koch CG, Kronik G, Kurtzke JF, Mather FJ, Mauch E, Michael Näbauer, Michael Strupp, Millefiorini E, Noseworthy JH, Posner LE, Reinhard Hohlfeld, Ruel M, Strotmann JM, Teichholz LE, Thomas Brandt, Vera Carina Zingler, Voltz R, Yudkin PL, Zephir H, Zingler VC   +36 more
core   +1 more source

Macrotroponin interference and association with cardiotoxicity in patients receiving cardiotoxic breast cancer therapy: a pilot study

Cardio-Oncology
Background Cancer therapy-related cardiac dysfunction (CTRCD) is an important adverse effect in patients receiving potential cardiotoxic cancer therapies.
Andrea Soosaipillai, Inbar Nardi-Agmon, Davor Brinc, Anselmo Fabros, Peter A. Kavsak, Paaladinesh Thavendiranathan, Ashley Di Meo   +6 more
doaj   +1 more source

5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report

BMC Cardiovascular Disorders, 2001
Background Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. Case presentation A case of 5-fluorouracil-induced cardiotoxicity, possibly
Campbell Norman PS, Webb Stephen T, McGlinchey Paul G   +2 more
doaj   +1 more source

MicroRNA in the Diagnosis and Treatment of Doxorubicin-Induced Cardiotoxicity [PDF]

, 2023
Ziyu Kuang, Jingyuan Wu, Ying Tan, Guanghui Zhu, Jie Li, Min Wu   +5 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

A spoonful of sugar: the application of glycopolymers in therapeutics [PDF]

, 2011
Glycopolymers, synthetic polymers displaying carbohydrate moieties, have been linked to many potential applications at the biology–chemistry interface. One area that holds particular promise is the employment of glycopolymers as vehicles for therapeutics
Cameron, Neil R., Spain, Sebastian G.
core   +2 more sources

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

Molecules, 2018
Doxorubicin (Dox) is a chemotherapeutic agent widely used for the treatment of numerous cancers. However, the clinical use of Dox is limited by its unwanted cardiotoxicity. Mitochondrial dysfunction has been associated with Dox-induced cardiotoxicity. To
Wei Shi, Hongkuan Deng, Jianyong Zhang, Ying Zhang, Xiufang Zhang, Guozhen Cui   +5 more
doaj   +1 more source

Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway [PDF]

, 2022
Nesrine Ebrahim, Hajir A. Al Saihati, Ola Mostafa, Amira Hassouna, Sameh Abdulsamea, Eman El-Gebaly, Nashwa H. Aborayah, Dina Sabry, Mohamed El‐Sherbiny, Abdelmonem G. Madboly, Noha I. Hussien, Raja El Hasnaoui- Saadani, Hasnaa Ali Ebrahim, Omnia A. Badr, Nehal M. Elsherbiny, Rabab F. Salim   +15 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source