Results 101 to 110 of about 119,936 (354)

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients [PDF]

, 2003
Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy.
Lersch, C., Reindl, L., Scherpinski, U., Seyfarth, M., Wacker, A.   +4 more
core   +1 more source

Docetaxel induced cardiotoxicity [PDF]

Heart, 2001
Docetaxel is a new taxoid antineoplastic agent.1 2Its mechanism of action is primarily related to its ability to enhance microtubule assembly and to stabilise microtubules by preventing their depolymerisation, thus disrupting normal cell division.2Since docetaxel has significant cytotoxic activity against human breast cancer in vitro and in vivo, it is
M, Shimoyama, Y, Murata, K I, Sumi, R, Hamazoe, I, Komuro   +4 more
openaire   +2 more sources

A Review on Effects of Cardiotoxic Drugs in Animal Models

JLUMHS, 2021
The major types of Cardiotoxicity in humans are mainly drug-induced, trauma, and stress-induced. Animal models for drug-induced Cardiotoxicity are generated by using various categories of drugs including anticancer, antiretroviral and antidiabetic, etc ...
Dr. Bader Alsuwayt
doaj   +1 more source

Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments

Frontiers in Cardiovascular Medicine, 2022
As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients ...
Wanli Sun, Juping Xu, Li Wang, Yuchen Jiang, Jingrun Cui, Xin Su, Fan Yang, Li Tian, Zeyu Si, Yanwei Xing   +9 more
doaj   +1 more source

Anthracycline-Induced Cardiotoxicity [PDF]

Acta Medica (Hradec Kralove, Czech Republic), 2000
Anthracycline antibiotics are among the most effective and widely used antineoplastic drugs. Their usefulness is limited by a cumulative dose-related cardiotoxicity, whose precise mechanisms are not clear as yet. The principal role is possibly exerted by free oxygen radicals generated by “redox-cycling“ of anthracycline molecule and/or by the formation
Radomír Hrdina, Vladimír Geršl, Ivona Klimtová, Tomáš Šimůnek, Jarmila Macháčková, Michaela Adamcová   +5 more
openaire   +3 more sources

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Left Ventricular Regional Wall Motion Abnormality is a Strong Predictor of Cardiotoxicity in Breast Cancer Patients Undergoing Chemotherapy

Arquivos Brasileiros de Cardiologia, 2018
Background: Chemotherapeutic agents of anthracyclines class and humanized monoclonal antibodies are effective treatments for breast cancer, however, they present a potential risk of cardiotoxicity. Several predictors have been recognized as predictors in
Márcio Vinícius Lins de Barros, Ariane Vieira Scarlatelli Macedo, Sebastian Imre Sarvari, Monica Hermont Faleiros, Patricia Tavares Felipe, Jose Luiz Padilha Silva, Thor Edvardsen   +6 more
doaj   +1 more source

Electrophysiological and molecular mechanisms of protection by iron sucrose against phosphine-induced cardiotoxicity: A time course study [PDF]

, 2015
The present study was designed for determining the exact mechanism of cytotoxic action of aluminum phosphide (AlP) in the presence of iron sucrose as the proposed antidote.
Abdollahi, M., Baeeri, M., Baghaei, A., Golaghaei, A., Hasani, S., Hosseini, R., Navaei, M., Ostad, S.N., Solgi, R.   +8 more
core   +1 more source