Results 81 to 90 of about 119,936 (354)

The Role of Flavonoids as a Cardioprotective Strategy against Doxorubicin-Induced Cardiotoxicity: A Review

Molecules, 2022
Doxorubicin is a widely used and promising anticancer drug; however, a severe dose-dependent cardiotoxicity hampers its therapeutic value. Doxorubicin may cause acute and chronic issues, depending on the duration of toxicity.
R. A. Syahputra, U. Harahap, A. Dalimunthe, M. P. Nasution, Denny Satria   +4 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A retrospective analysis of the association of obesity with anthracycline- and trastuzumab-induced cardiotoxicity in the treatment of breast cancer and lymphoma

Archives of Medical Science
Introduction Trastuzumab and anthracyclines are mainstays of chemotherapy in breast cancer and lymphoma patients but may cause significant cardiotoxicity, which may result in alterations to chemotherapy dose, schedule, or agent.
Mallorie L. Huff, Ranju Gupta, Rahul Gupta, Kelly C. Schadler, Shae Duka, Vienna Histon-Figliolini, Joshua Kalter, Amogh M. Joshi, Nadeem V. Ahmad, Wilbert S. Aronow, Deborah W. Sundlof   +10 more
doaj   +1 more source

Utility of myocardial work by echocardiography in the early diagnosis of cardiotoxicity [PDF]

Exploration of Cardiology
Aim: Evaluate the role of myocardial work by echocardiography and determine its utility as an early diagnosis of cardiotoxicity. Methods: Single-center included 180 patients over 18 years old undergoing chemotherapy, the definition of cardiotoxicity for ...
Denise Cortes-Pérez, Diana Romero-Zertuche, Gabriela Rodríguez-Guzmán, Itzel Calixto-Guízar, Carlos Martínez-Hernández   +4 more
doaj   +1 more source

Role of acetylation in doxorubicin-induced cardiotoxicity

Redox Biology, 2021
As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of a variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and pathogenesis has traditionally been attributed to the formation ...
Daisong Li, Yanyan Yang, Shizhong Wang, Xiangqin He, Meixin Liu, Baochen Bai, Chao Tian, Ruicong Sun, Tao Yu, Xianming Chu   +9 more
doaj   +1 more source

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]

, 2017
Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto, Benvenuto, Monica, Bergante, Sonia, Giganti, Maria Gabriella, Manzari, Vittorio, Masuelli, Laura, Mattera, Rosanna, Modesti, Andrea, Pluchinotta, Francesca Romana, Tettamanti, Guido, Tresoldi, Ilaria   +10 more
core   +2 more sources

An update of the molecular mechanisms underlying anthracycline induced cardiotoxicity

Frontiers in Pharmacology
Anthracycline drugs mainly include doxorubicin, epirubicin, pirarubicin, and aclamycin, which are widely used to treat a variety of malignant tumors, such as breast cancer, gastrointestinal tumors, lymphoma, etc.
Sicong Xie, Yuwei Sun, Xuan Zhao, Yiqun Xiao, Fei Zhou, Liang Lin, Wei Wang, Bin Lin, Zun Wang, Zixuan Fang, Lei Wang, Yang Zhang   +11 more
semanticscholar   +1 more source

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity

European Heart Journal, 2022
Aims Cardiotoxicity leading to heart failure (HF) is a growing problem in many cancer survivors. As specific treatment strategies are not available, RNA discovery pipelines were employed and a new and powerful circular RNA (circRNA)-based therapy was ...
Dongchao Lu, Shambhabi Chatterjee, K. Xiao, I. Riedel, Cheng-Kai Huang, Alessia Costa, Sarah Cushman, Dimyana Neufeldt, L. Rode, Arne Schmidt, M. Juchem, Julia Leonardy, G. Büchler, Jonas Blume, Olivia Luise Gern, U. Kalinke, W. Tan, R. Foo, A. Vink, L. V. van Laake, P. van der Meer, C. Bär, T. Thum   +22 more
semanticscholar   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source