Results 71 to 80 of about 64,429 (258)

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

Advanced Science, EarlyView.
The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng, Renjing Yang, Yu Du, Jingzhong Duan, Yiming Xu, Zhihua He, Guanghui Wang, Wenjing Tian, Aijie Liu, Haifeng Chen, Yun‐Bao Jiang, Xiaosheng Yan   +11 more
wiley   +1 more source

5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report

BMC Cardiovascular Disorders, 2001
Background Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. Case presentation A case of 5-fluorouracil-induced cardiotoxicity, possibly
Campbell Norman PS, Webb Stephen T, McGlinchey Paul G   +2 more
doaj   +1 more source

Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells

Stem Cell Research & Therapy, 2020
Background Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan—increasing clinical case reports have documented that it could ...
Rui Liu, Dong Li, Fangxu Sun, Antonio Rampoldi, Joshua T. Maxwell, Ronghu Wu, Peter Fischbach, Sharon M. Castellino, Yuhong Du, Haian Fu, Anant Mandawat, Chunhui Xu   +11 more
doaj   +1 more source

Current views on anthracycline cardiotoxicity

, 2016
Anthracyclines are well established and effective anticancer agents used to treat a variety of adult and pediatric cancers. Unfortunately, these drugs are also among the commonest chemotherapeutic agents that have been recognized to cause cardiotoxicity.
MERCURO, GIUSEPPE, Mele D., Madonna R., Malagù, Michele, Malagu M., Mele, D, TOCCHETTI, CARLO GABRIELE, Mele, Donato, Tocchetti C. G., Frassoldati, A, MALAGU', Michele, Cadeddu C., Mercuro G., Ferrari, Roberto, Spallarossa, P, Nardozza, Marianna, Ferrari R., Tocchetti, Carlo G., Madonna, R, Malagù, M, Mercuro, G., Madonna, Rosalinda, Frassoldati, Antonio, CADEDDU DESSALVI, CHRISTIAN, Nardozza M., Frassoldati A., Cadeddu, C, Cadeddu, Christian, Spallarossa, Paolo, Nardozza, M, Ferrari, R, Spallarossa P.   +31 more
core   +1 more source

High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients [PDF]

, 2003
Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy.
Lersch, C., Wacker, A., Scherpinski, U., Reindl, L., Seyfarth, M., Wacker, Annette;Lersch, Christian;Scherpinski, Ute;Reindl, Laurence;Seyfarth, Melchior, Wacker, A;Lersch, C;Scherpinski, U;Reindl, L;Seyfarth, M   +6 more
core   +1 more source

A Generative AI Framework to Predict Cardiomyocyte Contraction Function From Single Static Images

Advanced Intelligent Discovery, EarlyView.
A single static hiPSC‐cardiomyocyte image is fed into a U‐Net‐GAN framework, which directly predicts a pixel‐resolved contraction heatmap without time‐lapse imaging. StyleGAN2‐generated synthetic cell–heatmap pairs augment training, improving prediction fidelity (SSIM = 0.84).
Andrew Kowalczewski, Chenyan Wang, Xinrui Wang, Huaxiao Yang, Zhao Qin, Zhen Ma   +5 more
wiley   +1 more source

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

Molecules, 2018
Doxorubicin (Dox) is a chemotherapeutic agent widely used for the treatment of numerous cancers. However, the clinical use of Dox is limited by its unwanted cardiotoxicity. Mitochondrial dysfunction has been associated with Dox-induced cardiotoxicity. To
Wei Shi, Hongkuan Deng, Jianyong Zhang, Ying Zhang, Xiufang Zhang, Guozhen Cui   +5 more
doaj   +1 more source

Incidência de miocardiopatia pós-quimioterapia por linfoma não-hodgkin no Hospital Universitário Polydoro Ernani de São Tiago [PDF]

, 2009
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Lacerda, Marcelo Petombeira de
core  

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source