Results 271 to 280 of about 119,936 (354)

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Malnutrition, cachexia and sarcopenia as susceptibility factors for cardiovascular complications in patients with cancer. [PDF]

Front Pharmacol
Papasotiriou I, Tentolouris A, Ntanasis-Stathopoulos I, Liontos M.   +3 more
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

predicTox: an integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs. [PDF]

Database (Oxford)
Hansen J, Martinez P, Yadaw AS, Xiong Y, Racz R, Pacanowski MR, Hopkins LL, King NMP, Abernethy D, Sobie E, Iyengar R.   +10 more
europepmc   +1 more source

Early Detection of Acute and Early‐Onset Cancer Therapy‐Related Cardiac Dysfunction in Children With Cancer Using a Multiparametric Approach: Methodological Aspects of the EARLY Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Cancer therapy‐related cardiac dysfunction (CTRCD) is among the most important adverse effects of treatment of childhood cancer. In the EARLY study (Early detection of acute and early‐onset cARdiovascuLar toxicity in children with cancer using a multiparametric approach), cardiac function in children treated for cancer was monitored
Theodorus W. Kouwenberg, Heynric B. Grotenhuis, Leontien C. M. Kremer, Esmée C. de Baat, Auke Beishuizen, Max M. van Noesel, Livia Kapusta, Rutger A. J. Nievelstein, Birgitta K. Velthuis, Martijn G. Slieker, Tim Leiner, Bianca A. W. Hoeben, Annelies M. C. Mavinkurve‐Groothuis, Elizabeth A. M. Feijen   +13 more
wiley   +1 more source

Cysteine imaging reveals early redox dysregulation and identifies gnetol as a ferroptosis-modulating agent in doxorubicin cardiotoxicity. [PDF]

Redox Biol
Chen Y, Zhang B, Wei Y, Dai Y, Zhang B, Li J, Wu KJ, Sun N, Shao C.   +8 more
europepmc   +1 more source

Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Introduction Cervical cancer remains a leading cause of cancer‐related mortality among women globally, particularly in low‐ and middle‐income countries. Cisplatin, a standard chemotherapeutic agent, is limited by severe toxicities and chemoresistance. This study aimed to assess the effects of cisplatin in combination with phytocannabinoids, Δ9‐
S. P. Mathibela, M. T. Lebelo, V. Steenkamp   +2 more
wiley   +1 more source

Anthracyclines and the Heart: A Double-edged Sword With Therapeutic Hopes. [PDF]

J Saudi Heart Assoc
Alotaibi TM, Samman AM, Al Ghamdi AA, Alkhamis FS, Alnuwaiser FA, Alabdulgader AA, Aljizeeri AH.   +6 more
europepmc   +1 more source

The Efficacy and Toxicity of CNS Prophylaxis in Diffuse Large B‐Cell Lymphoma (CLSG‐CNS‐01): A Randomized, Multicenter, Prospective Phase 3 Trial

Hematological Oncology, Volume 44, Issue 3, May 2026.
ABSTRACT The randomized, multicenter, prospective Phase 3 trial (NCT02777736) evaluated central nervous system (CNS) prophylaxis using either intravenous (i.v.) or intrathecal (i.t.) methotrexate (MTX) in diffuse large B‐cell lymphoma (DLBCL). Treatment consisted of six cycles of R‐CHOP + 2xR or DA‐EPOCH‐R + 2xR. Patients with intermediate or high‐risk
H. Mocikova, L. Gaherova, T. Jancarkova, A. Suri, A. Janikova, K. Steinerova, D. Belada, R. Pytlik, J. Duras, M. Trnkova, P. Blahovcova, T. Kozak, M. Trneny   +12 more
wiley   +1 more source

Effectiveness of self-management interventions in reducing cancer treatment-related cardiotoxicity in breast cancer survivors: A systematic review. [PDF]

Asia Pac J Oncol Nurs
Yang M, Yang Q, Tse G, Ma Y, Lyu QY, Wang W, Lai AY, Zhang Y, Wong CWM, Liu X.   +9 more
europepmc   +1 more source