Results 171 to 180 of about 2,663,645 (303)

CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine

Med Research, EarlyView.
ABSTRACT Sepsis remains a leading cause of mortality worldwide due to its profound biological heterogeneity. While multi‐omics approaches offer promise for precision medicine, existing datasets often lack longitudinal granularity or comprehensive clinical integration. We present the Chinese Multi‐omics Advances In Sepsis (CMAISE) cohort, a prospective,
Jie Yang, Suibi Yang, Jiajun Cai, Songzan Qian, Shuping Song, Jun Guo, Yang Wang, Jinyan Xing, Bo Zhang, Zhihao Wang, Shengze Wu, Xinhao Jin, Bowen Tan, Dongdong Yang, Yao Yan, Haoran Chen, Changlin Sun, Kang Zou, Yuxin Leng, Jingye Pan, Tianlong Zhang, Yiming Shao, Lina Xian, Hongjun Kang, Zhen Wang, Ruilan Wang, Nan Wang, Lvyin Yan, Kun Cheng, Songqiao Liu, Lin Chen, Caibao Hu, Fuhong Su, Qian Gao, Yi Yang, Zhongheng Zhang, On behalf of Chinese Multi‐omics Advances In Sepsis (CMAISE) Consortium   +36 more
wiley   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

The clinical importance of the cardiovascular-kidney-metabolic syndrome and related mortality. [PDF]

Front Clin Diabetes Healthc
Hoffmann K, Paczkowska A, Maggio V, Rizzo M.   +3 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Sex differences in the progression of cardiovascular-kidney-metabolic syndrome. [PDF]

Eur Heart J Open
Taya S, Ejiri K, Kaneko H, Suzuki Y, Miyoshi T, Mizuno A, Ko T, Jimba T, Azegami T, Okada A, Fujiu K, Takeda N, Morita H, Hayashi K, Node K, Nangaku M, Yasunaga H, Takeda N, Yuasa S.   +18 more
europepmc   +1 more source

Associations between body mass index categories and geriatric assessment tests among older adults with chronic kidney disease: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background The optimal body mass index (BMI) among older adults with chronic kidney disease (CKD) in geriatric assessment tests has not been studied. This study investigates the relationship between BMI and Comprehensive Geriatric Assessment (CGA) parameters among older adults with CKD.
Yelda Deligöz Bildaci, Cihan Heybeli, Lee Smith, Masoud Rahmati, Dong Keon Yon, Pinar Soysal   +5 more
wiley   +1 more source

Association between serum bicarbonate and low mid‐upper arm circumference in patients with non‐dialysis‐dependent chronic kidney disease: A cross‐sectional study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Although previous experimental studies showed that metabolic acidosis promoted muscle catabolism and impaired protein synthesis, few epidemiological studies reported an independent association between serum bicarbonate levels and muscle atrophy in patients with chronic kidney disease (CKD).
Nobuhisa Morimoto, Shintaro Mandai, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Shotaro Naito, Eisei Sohara, Tatsuhiko Anzai, Kunihiko Takahashi, Wataru Akita, Akihito Ohta, Shinichi Uchida, Soichiro Iimori   +13 more
wiley   +1 more source

The Associations of Anthropometric Indices With Stages and Mortality in Cardiovascular-Kidney-Metabolic Syndrome: Insights From NHANES. [PDF]

Rev Cardiovasc Med
Zhong M, Liu CN, Chen Y.
europepmc   +1 more source

Beyond BMI: The Impact of the New Lancet Commission Diagnostic Criteria on Prevalence of Obesity in the United States

Obesity, EarlyView.
ABSTRACT Objective This study compared population characteristics and overall US prevalence of obesity over time using the BMI criteria and the 2025 Lancet Commission criteria (i.e., the Excess Adiposity criteria). Methods We analyzed data from 58,053 adults aged ≥ 20 years in the National Health and Nutrition Examination Survey from 1999 to 2023.
Jennifer H. Hwang, Neda Laiteerapong
wiley   +1 more source

Development and Validation of a Nomogram Incorporating Preoperative N‐Terminal Pro‐Brain Natriuretic Peptide to Predict Major Adverse Cardiovascular Events in Renal Transplant Recipients

Organ Medicine, EarlyView.
We developed and validated a preoperative nomogram incorporating NT‐proBNP to predict major adverse cardiovascular events in renal transplant recipients. Using a LASSO‐Cox model based on 582 training and 181 validation cases, we identified NT‐proBNP, age, body mass index, diabetes, and retransplantation as key predictors.
Guobin Wu, Chang Wang, Qihao Li, Shuangjin Yu, Linjie Peng, Jianliang Min, Weijie Lai, Haiwei Chen, Jiang Qiu, Guodong Chen   +9 more
wiley   +1 more source