Results 61 to 70 of about 2,663,645 (303)

Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice [PDF]

, 2016
Diabetic patients suffer from a high rate of cardiovascular events and such risk increases with HbA1c. However, lowering HbA1c does not appear to yield the same benefit on macrovascular endpoints, as observed for microvascular endpoints. As the number of
Avogaro, Angelo, Bonora, Enzo, Fadini, GIAN PAOLO, Prato, Stefano Del, Sesti, Giorgio   +4 more
core   +3 more sources

Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology
The American Heart Association (AHA) has recently introduced the concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome, which is the result of an increasing emphasis on the interplay of metabolic, renal and cardiovascular diseases (CVD). Furthermore,
Weipeng Li, Chaonan Shen, Weiya Kong, Xiaohui Zhou, H. Fan, Yuzhen Zhang, Zhongmin Liu, Liang Zheng   +7 more
semanticscholar   +1 more source

Interpretation of A Focus Shift From Sarcopenia to Muscle Health in the Asian Working Group for Sarcopenia 2025 Consensus Update

AGING MEDICINE, EarlyView.
The AWGS 2025 consensus shifts focus from diagnosing sarcopenia to promoting muscle health across the lifespan. It simplifies diagnosis to low muscle mass plus low strength, expands screening to middle‐aged adults, and integrates muscle health into the WHO ICOPE framework for early intervention and healthy aging.
Bi Jianghan, Li Jiaojiao, Kang Lin
wiley   +1 more source

Machine Learning‐Driven Digital Twin of a Field‐Effect Transistor‐Based Hormone Biosensor for Real‐Time Estradiol Monitoring

Advanced Intelligent Systems, EarlyView.
A machine learning‐driven digital twin simulates an aptamer‐functionalized BioFET measuring 17β‐estradiol. Real‐time Isd signals are processed, features are extracted, and trained models estimate hormone concentration. In parallel, a one‐step‐ahead forward model learns biosensor dynamics and generates realistic synthetic signals, enabling in silico ...
Anastasiia Gorelova, Alexandra Parichenko, Shirong Huang, Santiago Melia, Gianaurelio Cuniberti   +4 more
wiley   +1 more source

A holistic approach to managing cardio-kidney metabolic syndrome: insights and recommendations from the Italian perspective

Frontiers in Cardiovascular Medicine
Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality.
Massimo Iacoviello, Mauro Gori, Giuseppe Grandaliano, Giuseppe Grandaliano, Roberto Minutolo, Dario Pitocco, Roberto Trevisan, Roberto Trevisan   +7 more
doaj   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Social Determinants of Health in the Development of Cardiovascular-kidney-metabolic Syndrome

Reviews in Cardiovascular Medicine
Cardiovascular-kidney-metabolic (CKM) syndrome is characterized by the interactions among the metabolic risk factors, chronic kidney diseases (CKD) and cardiovascular diseases (CVD).
Xinyi Cai, Tuo Li
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease

Diabetology & Metabolic Syndrome
Background Metabolic Syndrome—a constellation of insulin resistance, cardiovascular risk factors as hyperglycemia, hypertension, and dyslipidemia, and systemic metabolic dysfunction—may be driven by dysregulation of adipose tissue, which manifests as ...
Amélio F. Godoy-Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo-Neto, Andrei C. Sposito, José Hermógenes Rocco Suassuna   +5 more
doaj   +1 more source

Pre-pregnancy predictors of hypertension in pregnancy among Aboriginal and Torres Strait Islander women in north Queensland, Australia; a prospective cohort study [PDF]

, 2013
BACKGROUND Compared to other Australian women, Indigenous women are frequently at greater risk for hypertensive disorders of pregnancy. We examined pre-pregnancy factors that may predict hypertension in pregnancy in a cohort of Aboriginal and Torres ...
Adrian Esterman, B Jim, B McCulloch, B Sibai, C De Costa, C Hatzis, C Rudra, CL Roberts, D Jacobs, D Leonard, D Trewin, G Miller, G Zavorsky, H Abenhaim, I Mertens, J Neter, J Roberts, J Roberts, J Roberts, John Lynch, K Duckitt, K Joseph, K O’Dea, K Panaretto, KL Coyne, L Callaway, M Lindheimer, M Samuels-Kalow, R McDermott, Robyn McDermott, S Campbell, Sandra K Campbell, V Flenady, V Rodie, W Gilbert, W Hoy, World Health Organisation   +36 more
core   +2 more sources