Results 71 to 80 of about 8,503,937 (347)

Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association.

open access: yesArteriosclerosis, Thrombosis and Vascular Biology, 2021
High levels of lipoprotein(a) [Lp(a)], an apoB100-containing lipoprotein, are an independent and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms associated with increased atherogenesis, inflammation, and thrombosis. Lp(a)
G. Reyes-Soffer   +9 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence

open access: yesEuropean Cardiology Review, 2019
Electronic cigarettes use is a growing trend in contemporary societies, with the propensity to compete with traditional tobacco smoking. Some preclinical studies demonstrated the toxic and detrimental effects of electronic cigarettes liquid components ...
Domenico D’Amario   +9 more
doaj   +1 more source

Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications

open access: yesEuropean Journal of Preventive Cardiology, 2019
The global prevalence of diabetes is predicted to increase dramatically in the coming decades as the population grows and ages, in parallel with the rising burden of overweight and obesity, in both developed and developing countries.
Elisa Dal Canto   +7 more
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Dysglycemia and Cardiovascular Risk

open access: yesJournal of the American College of Cardiology, 2012
I read with interest the “state-of-the art” paper by Grundy ([1][1]) that was recently published in the Journal . The paper demonstrated that the pre-diabetic range of glucose levels do not directly cause atherosclerosis or its complications, on the basis of a systemic review of the ...
openaire   +3 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Periodontal therapy and cardiovascular risk.

open access: yesPeriodontology, 2020
Cardiovascular diseases are the worldwide leading cause of mortality. Cardiovascular diseases are noncommunicable conditions with a complex pathogenesis, and their clinical manifestations include major cardiovascular events such as myocardial infarction ...
M. Orlandi, F. Graziani, F. D’Aiuto
semanticscholar   +1 more source

NSAIDs and cardiovascular risk [PDF]

open access: yesKidney International, 2014
To the Editor: In the recent article by Wei et al.,1 it was concluded that nonsteroidal anti-inflammatory drug (NSAID) prescribing decreased after the introduction of estimated glomerular filtration rate (eGFR) reporting in April 2006 within primary care.
Bell, Samira, Marwick, Charis A
openaire   +4 more sources

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