Results 21 to 30 of about 19,257,501 (304)

Role of Arginase-II in Podocyte Injury under Hypoxic Conditions

Biomolecules, 2022
Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal tubular and glomerular cell damage. Some studies provide evidence that hypoxia-dependent upregulation of the mitochondrial enzyme arginase type-II (Arg-II) in ...
Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang   +6 more
doaj   +1 more source

Roadmap for alleviating the manifestations of ageing in the cardiovascular system [PDF]

Nature Reviews Cardiology
Konstantinos Stellos, Simon Tual-Chalot, Luca Liberale   +2 more
exaly   +2 more sources

Coupled Oscillators - Complex but Not Complicated Cardiovascular and Brain Interactions. [PDF]

, 2007
In coupled nonlinear oscillators approach, the framework that has been used for the studies of cardiovascular and brain oscillations. As background, it describes the human CVS and present results of time-frequency analysis using wavelet transforms of ...
Stefanovska, Aneta
core   +4 more sources

Clinical Characteristics, Sex Differences, and Outcomes in Patients With Normal or Near‐Normal Coronary Arteries, Non‐Obstructive or Obstructive Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundNormal or near‐normal coronary arteries (NNCAs) or nonobstructive coronary artery disease (CAD) are found on invasive coronary angiography in ≈55% of patients. Some attribute this to frequent referral of low‐risk patients. We sought to identify
Michelle L. Ouellette, Adrián I. Löffler, George A. Beller, Virginia K. Workman, Eric Holland, Jamieson M. Bourque   +5 more
doaj   +1 more source

Role of tubular epithelial arginase-II in renal inflammaging

npj Aging and Mechanisms of Disease, 2021
The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men.
Ji Huang, Xiujie Liang, Diogo Ladeiras, Benoit Fellay, Xiu-Fen Ming, Zhihong Yang   +5 more
doaj   +1 more source

Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease [PDF]

, 2020
Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondria! dysfunction is
Ryu, Dongryeol, Oh, Chang-Myung, Jang, Yangsoo, Cho, Sungsoo   +3 more
core   +1 more source

The use of enoxaparin as bridge to therapeutic INR after LVAD implantation

Journal of Cardiothoracic Surgery, 2020
Background Left ventricular assist devices (LVAD) have been increasingly used in the treatment of end-stage heart failure. While warfarin has been uniformly recommended in the long-term as anticoagulation strategy, no clear recommendation exists for the ...
Zubair Shah, Ioannis Mastoris, Prakash Acharya, Aniket S. Rali, Moghni Mohammed, Sami Farhad, Sagar Ranka, Savahanna Wagner, Giorgio Zanotti, Christopher T. Salerno, Nicholas A. Haglund, Andrew J. Sauer, Ashwin K. Ravichandran, Travis Abicht   +13 more
doaj   +1 more source

Cyclooxygenases and the cardiovascular system [PDF]

Pharmacology & Therapeutics, 2021
Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the cardiovascular system with a range of diverse, sometimes opposing, functions. Through the production of thromboxane, COX in platelets is a pro-thrombotic enzyme. By contrast, through the production of prostacyclin, COX in endothelial cells is antithrombotic and in the kidney ...
Mitchell, Jane A, Kirkby, Nicholas S, Ahmetaj-Shala, Blerina, Armstrong, Paul C, Crescente, Marilena, Ferreira, Plinio, Lopes Pires, Maria Elisa, Vaja, Ricky, Warner, Timothy D   +8 more
openaire   +4 more sources

Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease

Nature Communications, 2018
The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression ...
Matthew Ackers-Johnson, Wilson Lek Wen Tan, Roger Sik-Yin Foo   +2 more
doaj   +1 more source

Coronavirus Disease 2019: Where are we and Where are we Going? Intersections Between Coronavirus Disease 2019 and the Heart

Cardiac Failure Review, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has become a pandemic affecting every country in the world.
Emilia D’Elia, Michele Senni
doaj   +1 more source