Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease [PDF]
, 2020 Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondria! dysfunction is
Ryu, Dongryeol +3 more
core +1 more source
Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation [PDF]
, 2022 A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and ...
Natalia Linkova +4 more
core +1 more source
Functions of RNA-Binding Proteins in Cardiovascular Disease [PDF]
, 2023 Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding proteins (RBPs).
Lejla Medzikovic +4 more
core +1 more source
Immunosuppressive Agents—Effects on the Cardiovascular System and Selected Metabolic Aspects: A Review [PDF]
, 2023 The widespread use of immunosuppressive drugs makes it possible to reduce inflammation in autoimmune diseases, as well as prevent transplant rejection in organ recipients. Despite their key action in blocking the body’s immune response, these drugs
Marta Grabowska +2 more
core +1 more source
Role of Arginase-II in Podocyte Injury under Hypoxic Conditions
Biomolecules, 2022 Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal tubular and glomerular cell damage. Some studies provide evidence that hypoxia-dependent upregulation of the mitochondrial enzyme arginase type-II (Arg-II) in ...
Zhilong Ren +6 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundNormal or near‐normal coronary arteries (NNCAs) or nonobstructive coronary artery disease (CAD) are found on invasive coronary angiography in ≈55% of patients. Some attribute this to frequent referral of low‐risk patients. We sought to identify
Michelle L. Ouellette +5 more
doaj +1 more source
Role of tubular epithelial arginase-II in renal inflammaging
npj Aging and Mechanisms of Disease, 2021 The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men.
Ji Huang +5 more
doaj +1 more source
Cardiovascular System Sonographic Evaluation Algorithm [PDF]
, 2015 Objectives: To evaluate the reproducibility and feasibility of the new cardiovascular system sonographic evaluation algorithm for studying the extended fetal cardiovascular system, including the portal, thymic, and supra-aortic areas, in the second ...
Gámez Alderete, Francisco De Asis +3 more
core +1 more source
Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease [PDF]
, 2021 Cardiovascular disease is the leading cause of accelerated as well as chronological aging-related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles including daily consumption of high-carb/high-fat fast food, lack of ...
Asish K. Ghosh
core +1 more source
The use of enoxaparin as bridge to therapeutic INR after LVAD implantation
Journal of Cardiothoracic Surgery, 2020 Background Left ventricular assist devices (LVAD) have been increasingly used in the treatment of end-stage heart failure. While warfarin has been uniformly recommended in the long-term as anticoagulation strategy, no clear recommendation exists for the ...
Zubair Shah +13 more
doaj +1 more source