Results 11 to 20 of about 1,338,598 (269)

Role of tubular epithelial arginase-II in renal inflammaging

npj Aging and Mechanisms of Disease, 2021
The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men.
Ji Huang, Xiujie Liang, Diogo Ladeiras, Benoit Fellay, Xiu-Fen Ming, Zhihong Yang   +5 more
doaj   +1 more source

Role of Arginase-II in Podocyte Injury under Hypoxic Conditions

Biomolecules, 2022
Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal tubular and glomerular cell damage. Some studies provide evidence that hypoxia-dependent upregulation of the mitochondrial enzyme arginase type-II (Arg-II) in ...
Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang   +6 more
doaj   +1 more source

Clinical Characteristics, Sex Differences, and Outcomes in Patients With Normal or Near‐Normal Coronary Arteries, Non‐Obstructive or Obstructive Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundNormal or near‐normal coronary arteries (NNCAs) or nonobstructive coronary artery disease (CAD) are found on invasive coronary angiography in ≈55% of patients. Some attribute this to frequent referral of low‐risk patients. We sought to identify
Michelle L. Ouellette, Adrián I. Löffler, George A. Beller, Virginia K. Workman, Eric Holland, Jamieson M. Bourque   +5 more
doaj   +1 more source

The use of enoxaparin as bridge to therapeutic INR after LVAD implantation

Journal of Cardiothoracic Surgery, 2020
Background Left ventricular assist devices (LVAD) have been increasingly used in the treatment of end-stage heart failure. While warfarin has been uniformly recommended in the long-term as anticoagulation strategy, no clear recommendation exists for the ...
Zubair Shah, Ioannis Mastoris, Prakash Acharya, Aniket S. Rali, Moghni Mohammed, Sami Farhad, Sagar Ranka, Savahanna Wagner, Giorgio Zanotti, Christopher T. Salerno, Nicholas A. Haglund, Andrew J. Sauer, Ashwin K. Ravichandran, Travis Abicht   +13 more
doaj   +1 more source

Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease

Nature Communications, 2018
The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression ...
Matthew Ackers-Johnson, Wilson Lek Wen Tan, Roger Sik-Yin Foo   +2 more
doaj   +1 more source

Coronavirus Disease 2019: Where are we and Where are we Going? Intersections Between Coronavirus Disease 2019 and the Heart

Cardiac Failure Review, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has become a pandemic affecting every country in the world.
Emilia D’Elia, Michele Senni
doaj   +1 more source

A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose

Clinical and Translational Science, 2021
N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose.
James W Dear, Mei Li Ng, D. Nicholas Bateman, Pakkiri Leroy Sivappiragasam, Hyungwon Choi, Benjamin Bing Jie Khoo, Baharudin Ibrahim, Chester Lee Drum   +7 more
doaj   +1 more source

Emergency Valve-in-Valve Transcatheter Aortic Valve Implantation for the Treatment of Acute Stentless Bioprosthetic Aortic Insufficiency and Cardiogenic Shock

Case Reports in Cardiology, 2018
Bioprosthetic aortic valve degeneration may present as acute, severe aortic regurgitation and cardiogenic shock. Such patients may be unsuitable for emergency valve replacement surgery due to excessive risk of operative mortality but could be treatable ...
Ivan D. Hanson, Pratik K. Dalal, Brian M. Renard, George S. Hanzel, Alessandro Vivacqua   +4 more
doaj   +1 more source

Self-Expandable Transcatheter Aortic Valve Frame Infolding: An Increasingly Recognized Complication

European Journal of Case Reports in Internal Medicine, 2020
Transcatheter aortic valve replacement (TAVR) with either a balloon-expandable or a self-expandable transcatheter heart valve (THV) is an approved therapy for patients with symptomatic severe aortic stenosis and high or intermediate surgical risk.
Gurpreet Singh, Vien Le, Robert Wiechmann, Steven Schreiter   +3 more
doaj   +1 more source

Master of the Masquerade: An Atypical Presentation of Acute Aortic Dissection

Case Reports in Cardiology, 2020
Acute aortic dissection (AAD) is associated with unacceptably high mortality rate. As such, early diagnosis and aggressive management are essential in order to avoid life-threatening complications.
Ramy Mando, Daniel Tim, Anthony DeCicco, Justin Trivax, Ivan Hanson   +4 more
doaj   +1 more source