Results 81 to 90 of about 1,674,512 (285)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
KEDI Journal of Educational PolicyThis study aims to divide multicultural high school students into groups according to the changes in their perceived career barriers, analyze their predictive factors, and suggest measures to reduce their perceptions of career barriers.
Seon-hui Bae, Eun Young Son
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Scandinavian Journal of Disability Research, 2012 For decades, the employment of Norwegians with disabilities has been lower than for the rest of the population. One possible explanation is inaccessible transportation.
Kristin Ystmark Bjerkan +2 more
doaj +1 more source
A career in career - understanding what career looks like in the career development sector [PDF]
, 2017 There is little known about the careers workforce in the UK. This research focuses on developing a better understanding of who chooses to become a career development practitioner, their motivation, the transferable skills they bring with them and how ...
Neary, S. +2 more
core
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
International Journal of Multidisciplinary Educational Research and InnovationThe study aimed to understand the experiences of guidance coordinators in implementing career guidance programs in IP elementary schools. Fourteen guidance coordinators from the Municipality of Talaingod Davao del Norte were selected using purposive ...
Metchie D. Soliva +1 more
doaj +1 more source
Enhancing professionalism - progressing the career development sector [PDF]
, 2015 Much has changed in the career development sector since the launch of the Careers Profession Task Force report, ‘Towards a Strong Careers Profession’ in 2010.
Neary, Siobhan +2 more
core
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source