Results 71 to 80 of about 1,736,062 (293)

Group Types and Characteristics According to Changes in Levels of Perceived Career Barriers by Multicultural High School Students in Korea

KEDI Journal of Educational Policy
This study aims to divide multicultural high school students into groups according to the changes in their perceived career barriers, analyze their predictive factors, and suggest measures to reduce their perceptions of career barriers.
Seon-hui Bae, Eun Young Son
doaj   +1 more source

The Fifth National Career Leaders Conference [PDF]

, 2022
This article reflects on the recent Career Leaders Conference held at the University of Derby in June 2022. The report explains the importance of the event and the role that the University plays in supporting the career development ...
Moore, N.
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Career Guidance Program Implementation in Indigenous People Elementary Schools: The Chronicles of Guidance Coordinators

International Journal of Multidisciplinary Educational Research and Innovation
The study aimed to understand the experiences of guidance coordinators in implementing career guidance programs in IP elementary schools. Fourteen guidance coordinators from the Municipality of Talaingod Davao del Norte were selected using purposive ...
Metchie D. Soliva, Jodelle John A. Enriquez   +1 more
doaj   +1 more source

Transportation to employment

Scandinavian Journal of Disability Research, 2012
For decades, the employment of Norwegians with disabilities has been lower than for the rest of the population. One possible explanation is inaccessible transportation.
Kristin Ystmark Bjerkan, Marianne Elvsaas Nordtømme, An-Magritt Kummeneje   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Enhancing professionalism - progressing the career development sector [PDF]

, 2015
Much has changed in the career development sector since the launch of the Careers Profession Task Force report, ‘Towards a Strong Careers Profession’ in 2010.
Neary, Siobhan, Neary, S., Johnson, Claire   +2 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source