Results 111 to 120 of about 1,257,650 (344)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Online career construction for a trauma survivor with career choice ambivalence
South African Journal of Higher EducationThis article reports on the online administration of career construction counselling for a trauma survivor who sought help in resolving her career-choice ambivalence (uncertainty). The participant was purposively selected from a group of people attending
J. G. Maree
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A Model of Real Estate Sales as a Career Choice [PDF]
This article develops a model of the probability that individuals choose careers in real estate sales. The model is estimated using Census data. Females are found to be significantly more likely than males to enter the field.
Daniel T. Winkler, Donald Jud
core
Factors affecting career-related decisions within the contemporary pharmacy workforce in Australia
Exploratory Research in Clinical and Social PharmacyIntroduction: Pharmacists are essential to healthcare delivery in Australia, making effective workforce planning critical to ensure equitable health outcomes.
Jocelyn Bussing +2 more
doaj +1 more source
A REFLECTION ON UNIVERSITY STUDIES AND FURTHER CAREER DEVELOPMENT OF CHOSEN CULS FACULTIES’ GRADUATES [PDF]
Journal on Efficiency and Responsibility in Education and Science, 2010 The article is focused on professional orientation and direction of the careers of graduates of Faculty of Economics and Management (FEM) and Faculty of Agrobiology, Food and Natural Resources (FAFNR) at Czech University of Life Sciences Prague (CULS ...
Rymešová, Pavla, Kolman, Luděk
doaj
Comparing Holland and Self-Determination Theory Measures of Career Preference as Predictors of Career Choice [PDF]
, 2019 Kennon M. Sheldon +3 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
From values to choices: the mediating role of career adaptability of university engineering students
Frontiers in PsychologyIntroductionCareer choice is a complex and consequential process for university students, and it shapes their long-term career trajectories. This study examines the impact of career values on university engineering students' career choices and ...
Dan Wang +6 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source