Results 101 to 110 of about 51,889 (297)

Career self-management in ascription culture [PDF]

open access: yes, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThe main aim of this thesis is to investigate whether theories of career self-management, developed in the USA and Western countries, apply in cultures which
Alhaddad, Masalek
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Sustainable Career Cards Sort (SCCS): Linking Career Choices to the World Needs [PDF]

open access: yes, 2019
Recently, there has been a call for career counseling interventions that promote the construction of a more humane sustainable world. In fact, contemporary world is facing collateral crises at various levels, and career counselors should be able to help ...
Shékina Rochat   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

INNOVATIVE FORMS OF SOCIAL AND CULTURAL ACTIVITY, WHICH CONTRIBUTE TO THE FORMATION OF CAREER STRATEGIES OF YOUTH

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки, 2018
We actualize the process of formation of career strategies for students in conditions of self-management. Student self-management is considered from the standpoint of social and cultural activity and is defined as a special form of initiative ...
V. K. Botkova, E. I. Grigorieva
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Developing Career Capital for Global Careers: The Role of International Assignments [PDF]

open access: yes, 2005
Creating organizational processes which nurture global careers is a key task for global companies. International assignments are normally viewed as positive by both individuals and organizations for the development of global career competencies.
Dickmann, Michael, Harris, Hilary
core  

A Thematic Analysis of Career Adaptability in Retirees Who Return to Work

open access: yesFrontiers in Psychology, 2016
Retirement can no longer be conceptualized as disengagement, as the end of a person’s career, as it is in the life-span, life-space theory. Increasingly, retirees are returning to work, in paid and unpaid positions, in a part-time or full-time capacity,
Jennifer eLuke   +2 more
doaj   +1 more source

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