Results 91 to 100 of about 925,551 (292)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Career Adaptability and Career Construction as Mediating Variables Between Hardiness and Vocational Identity

International Journal for Research in Vocational Education and Training
Background: The Career Construction Theory (CCT) focuses on the active role people can play when they create and design their singular paths for career success.
Enrique Merino-Tejedor, María José Serrano-Fernández, Maria Boada-Cuerva, Beatriz Sora   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

INNOVATIVE FORMS OF SOCIAL AND CULTURAL ACTIVITY, WHICH CONTRIBUTE TO THE FORMATION OF CAREER STRATEGIES OF YOUTH

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018
We actualize the process of formation of career strategies for students in conditions of self-management. Student self-management is considered from the standpoint of social and cultural activity and is defined as a special form of initiative ...
V. K. Botkova, E. I. Grigorieva
doaj   +1 more source

A Study of women career in construction industry [PDF]

, 2015
The achievement of women in different field in Malaysia is no more hesitating which they can compete with men in the construction industry field. There are misconceptions that women are weak and unable to be good leader or workers as compared to men ...
Nurul Norliana, Salahuddin
core  

Constructing Your Career Plays

Sports Innovation Journal, 2022
The evolving landscape of job opportunities has led to increased concerns around life-career success of college student-athletes while and after they balance their academic and sport performance. At Kent State University (Division I) located in Kent, Ohio, Tracy Montgomery serves as the student-athlete career advisor liaison between Career Exploration &
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

From career exploration to experiencing well-being: the psychological mechanisms of university students’ career development

Frontiers in Psychology
Background and ObjectiveGuided by career construction theory, this study investigated the association between career exploration and subjective well-being among university students, with a focus on the roles of career adaptability and perceived control ...
Yue Dong, Sheng Lin, Xiaoxia Huang
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Thematic Analysis of Career Adaptability in Retirees Who Return to Work

Frontiers in Psychology, 2016
Retirement can no longer be conceptualized as disengagement, as the end of a person’s career, as it is in the life-span, life-space theory. Increasingly, retirees are returning to work, in paid and unpaid positions, in a part-time or full-time capacity,
Jennifer eLuke, Peter eMcIlveen, Harsha N. Perera   +2 more
doaj   +1 more source