Results 91 to 100 of about 3,763,257 (287)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

INNOVATIVE FORMS OF SOCIAL AND CULTURAL ACTIVITY, WHICH CONTRIBUTE TO THE FORMATION OF CAREER STRATEGIES OF YOUTH

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки, 2018
We actualize the process of formation of career strategies for students in conditions of self-management. Student self-management is considered from the standpoint of social and cultural activity and is defined as a special form of initiative ...
V. K. Botkova, E. I. Grigorieva
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

career service papers - csp 17/19

open access: yes, 2019
Themen dieser Ausgabe sind veränderte Anforderungen an Hochschule und Arbeitgeber*innen (Generation Z), Beiträge zu studentischen Praktika und zur Qualitätssicherung von Praktika, ein Beitrag zur Beschäftigungsfähigkeit und Qualitätssicherung im Rahmen ...
Dorenburg, Christiane   +9 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Modelling construction business performance [PDF]

open access: yes, 2008
Searching academic databases for records on ‘business failure’, ‘business distress’ or ‘bankruptcy’\ud yields a large body of studies on qualitative, empirical, theoretical and simulation aspects.

core  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

Adoption in the construction industry [PDF]

open access: yes, 2006
This report draws together the key findings from six case studies on the subject of ebusiness\ud Adoption in Construction conducted in Australia by the University of Newcastle\ud (UON) and Royal Melbourne Institute of Technology (RMIT) from 2005 through ...

core  

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