Results 61 to 70 of about 140,915 (300)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Reclaiming professional identity through postgraduate professional development: Career practitioners reclaiming their professional selves [PDF]

, 2014
Careers advisers in the UK have experienced significant change and upheaval within their professional practice. This research explores the role of postgraduate level professional development in contributing to professional identity. The research utilises
Bimrose J., Brown A., Brown A., Cabinet Office, Careers Profession Task Force, Colley H., Colley H., Council of the European Union, Dearing R., Department for Business Innovation and Skills, Department for Business Innovation and Skills, Department for Business Innovation and Skills, Department for Business Innovation and Skills, Department for Children, Schools and Families, Department for Education and Employment, Department for Education and Skills, Department for Innovation, University and Skills, Douglas F., Feinstein L., Hamel J., Harrison R., Hooley T., Howitt D., Institute of Career Guidance, Larson M., Mulvey R., Organisation for Economic Co-operation and Development, Peck D., Richardson P., Siobhan Neary, Skills Commission, Souhami A., Taylor J., Thomas G., Watts A. G., Watts A. G.   +35 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Study of vocational clients profile: implications for educational settings [PDF]

, 2008
Following recent recommendations for vocational intervention (e.g., Lent, 2001; Savickas, 2001; Fouad, 2001; Vondracek, 2001), and based on career theory and research, the mission of the Career Counselling Unit - Centre for Counselling Psychology and ...
Araújo, Alexandra Maria Dantas de Castro, Carvalho, Sara, Faria, Liliana, Loureiro, Nazaré, Silva, Ana Daniela, Taveira, Maria do Céu, Viola, Lara   +6 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Can aspiration kill local community? Challenges for young people and career practitioners in Sri Lanka [PDF]

, 2013
Raising aspiration is a primary focus of careers work. However, in some circumstances enhanced aspirations may create tensions in situations of limited accessible opportunity.
Neary, Siobhan
core   +1 more source

The need for structured career guidance in a resource-constrained South African school

African Journal of Career Development
Background: Career guidance and counselling in secondary schools are crucial for young adolescents as they embark on the initial stages of shaping their post-school studies and career goals. Initiating career guidance as early as Grade 9 is imperative to
Aretha Farao, Marieta du Plessis
doaj   +1 more source

Mature Students Speak Up: Career Exploration and the Working Alliance

Qualitative Research in Education, 2015
This exploratory study was undertaken to learn more about how mature students perceive the career counselling process in a post-secondary institution. Through the use of critical incident technique this study examined how three mature students interpret ...
Terilyn Pott
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Careers 2020: options for future careers work in English schools. [PDF]

, 2012
Careers work in English schools has endured much turbulence recently. The government has now established a statutory duty on schools to secure provision, placing commissioning of careers advice and guidance in the hands of schools rather than local ...
Coiffait, Louis, Hooley, Tristram, Marriott, John, Watts, A. G.   +3 more
core   +1 more source